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Enlarged lacrimal glands

MedGen UID:
401142
•Concept ID:
C1867030
•
Finding
Synonym: Enlarged tear gland
 
HPO: HP:0007734

Definition

Abnormally big lacrimal glands. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnlarged lacrimal glands

Conditions with this feature

Sarcoidosis, susceptibility to, 1
MedGen UID:
394568
•Concept ID:
C2697310
•
Finding
Any sarcoidosis in which the cause of the disease is a mutation in the HLA-DRB1 gene.
See: Condition Record
Sarcoidosis, susceptibility to, 1

Professional guidelines

PubMed

Change in lacrimal gland volume and aqueous tear production following treatment with teprotumumab.
Ugradar S, Zimmerman E, Parunakian E, Kang J, Cockerham K, Douglas RS
Clin Exp Ophthalmol 2023 May-Jun;51(4):339-348. Epub 2023 Feb 9 doi: 10.1111/ceo.14208. PMID: 36723406
Differential diagnosis of immunoglobulin G4-related sialadenitis and Kimura's disease of the salivary gland: a comparative case series.
Zhu WX, Zhang YY, Sun ZP, Gao Y, Chen Y, Yu GY
Int J Oral Maxillofac Surg 2021 Jul;50(7):895-905. Epub 2020 Dec 29 doi: 10.1016/j.ijom.2020.05.023. PMID: 33384237
Diagnostic criteria for IgG4-related ophthalmic disease.
Goto H, Takahira M, Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease
Jpn J Ophthalmol 2015 Jan;59(1):1-7. Epub 2014 Nov 14 doi: 10.1007/s10384-014-0352-2. PMID: 25392273

Recent clinical studies

Etiology

Radiological Determinants of Complicated Immunoglobulin G4-Related Ophthalmic Disease: A Territory-Wide Cohort Study.
Lai KKH, Chu WCW, Li EYM, Chan RYC, Wei Y, Jia R, Cheng ACO, Chan KKW, Chin JKY, Kwok JSW, Io IYF, Yip NKF, Li KKW, Chan WH, Lam NM, Yip WWK, Young AL, Chan E, Ko CKL, Ko STC, Yuen HKL, Tham CCY, Pang CP, Chong KKL
Asia Pac J Ophthalmol (Phila) 2022 Sep 1;11(5):417-424. doi: 10.1097/APO.0000000000000552. PMID: 36179335
Clinical, Radiological and Histopathological Features of Patients With Lacrimal Gland Enlargement.
Jamshidian Tehrani M, Asadi Khameneh E, Pourseyed Iazarjani SZ, Ghadimi H, Nozarian Z, Mokhtari M
Arch Iran Med 2021 Dec 1;24(12):910-915. doi: 10.34172/aim.2021.136. PMID: 35014239
Lacrimal gland abscess in children: Two case reports and literature review.
Lai THT, Lai FHP, Chan TCY, Young AL, Chong KKL
Orbit 2017 Dec;36(6):468-472. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337197. PMID: 28820293
Conjunctival biopsy in the diagnosis of sarcoidosis.
Spaide RF, Ward DL
Br J Ophthalmol 1990 Aug;74(8):469-71. doi: 10.1136/bjo.74.8.469. PMID: 2390521Free PMC Article

Diagnosis

IgG4-related disease as multiple head and neck swellings: supported by histopathology and immunohistochemistry.
Rehman O, Das D, Bhattacharjee K, Venkatraman V, Bhattacharjee H, Deka A
Rom J Ophthalmol 2022 Apr-Jun;66(2):164-167. doi: 10.22336/rjo.2022.32. PMID: 35935075Free PMC Article
Clinical, Radiological and Histopathological Features of Patients With Lacrimal Gland Enlargement.
Jamshidian Tehrani M, Asadi Khameneh E, Pourseyed Iazarjani SZ, Ghadimi H, Nozarian Z, Mokhtari M
Arch Iran Med 2021 Dec 1;24(12):910-915. doi: 10.34172/aim.2021.136. PMID: 35014239
Lacrimal gland abscess in children: Two case reports and literature review.
Lai THT, Lai FHP, Chan TCY, Young AL, Chong KKL
Orbit 2017 Dec;36(6):468-472. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337197. PMID: 28820293
Extramedullary hematopoiesis in the lacrimal gland.
Shinder R, Mirani N, Wu HV, Langer PD
Ophthalmic Plast Reconstr Surg 2008 Jan-Feb;24(1):48-50. doi: 10.1097/IOP.0b013e31815c9366. PMID: 18209642
Conjunctival biopsy in the diagnosis of sarcoidosis.
Spaide RF, Ward DL
Br J Ophthalmol 1990 Aug;74(8):469-71. doi: 10.1136/bjo.74.8.469. PMID: 2390521Free PMC Article

Therapy

Lacrimal gland abscess in children: Two case reports and literature review.
Lai THT, Lai FHP, Chan TCY, Young AL, Chong KKL
Orbit 2017 Dec;36(6):468-472. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337197. PMID: 28820293
A primary Sjögren's syndrome patient with marked swelling of multiple exocrine glands and sclerosing pancreatitis.
Akahane C, Takei Y, Horiuchi A, Kawa S, Nishimori I, Ikeda S
Intern Med 2002 Sep;41(9):749-53. doi: 10.2169/internalmedicine.41.749. PMID: 12322807

Clinical prediction guides

Radiological Determinants of Complicated Immunoglobulin G4-Related Ophthalmic Disease: A Territory-Wide Cohort Study.
Lai KKH, Chu WCW, Li EYM, Chan RYC, Wei Y, Jia R, Cheng ACO, Chan KKW, Chin JKY, Kwok JSW, Io IYF, Yip NKF, Li KKW, Chan WH, Lam NM, Yip WWK, Young AL, Chan E, Ko CKL, Ko STC, Yuen HKL, Tham CCY, Pang CP, Chong KKL
Asia Pac J Ophthalmol (Phila) 2022 Sep 1;11(5):417-424. doi: 10.1097/APO.0000000000000552. PMID: 36179335

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