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Respiratory Tract Aspiration

MedGen UID:
417600
•Concept ID:
C2827071
•
Finding
Synonym: Unintentional Material Aspiration

Definition

Accidental inhalation of a foreign material into the lungs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRespiratory Tract Aspiration

Professional guidelines

PubMed

Role of retrograde dilatation in the management of pharyngo-esophageal corrosive strictures.
Vimalraj V, Rajendran S, Jyotibasu D, Balachandar TG, Kannan D, Jeswanth S, Ravichandran P, Surendran R
Dis Esophagus 2007;20(4):328-32. doi: 10.1111/j.1442-2050.2007.00717.x. PMID: 17617882

Recent clinical studies

Etiology

Risk of an Adverse Event in Individuals Who Aspirate: A Review of Current Literature on Host Defenses and Individual Differences.
Palmer PM, Padilla AH
Am J Speech Lang Pathol 2022 Jan 18;31(1):148-162. Epub 2021 Nov 3 doi: 10.1044/2021_AJSLP-20-00375. PMID: 34731584
Aspiration syndromes and associated lung injury: incidence, pathophysiology and management.
Košutova P, Mikolka P
Physiol Res 2021 Dec 30;70(Suppl4):S567-S583. doi: 10.33549/physiolres.934767. PMID: 35199544Free PMC Article
Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia.
Marin-Corral J, Pascual-Guardia S, Amati F, Aliberti S, Masclans JR, Soni N, Rodriguez A, Sibila O, Sanz F, Sotgiu G, Anzueto A, Dimakou K, Petrino R, van de Garde E, Restrepo MI; GLIMP investigators
Chest 2021 Jan;159(1):58-72. Epub 2020 Jul 17 doi: 10.1016/j.chest.2020.06.079. PMID: 32687909
Pediatric Dysphagia: Physiology, Assessment, and Management.
Dodrill P, Gosa MM
Ann Nutr Metab 2015;66 Suppl 5:24-31. Epub 2015 Jul 24 doi: 10.1159/000381372. PMID: 26226994
Pathophysiology of pneumonia.
Alcón A, Fàbregas N, Torres A
Clin Chest Med 2005 Mar;26(1):39-46. doi: 10.1016/j.ccm.2004.10.013. PMID: 15802164

Diagnosis

Risk of an Adverse Event in Individuals Who Aspirate: A Review of Current Literature on Host Defenses and Individual Differences.
Palmer PM, Padilla AH
Am J Speech Lang Pathol 2022 Jan 18;31(1):148-162. Epub 2021 Nov 3 doi: 10.1044/2021_AJSLP-20-00375. PMID: 34731584
Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia.
Marin-Corral J, Pascual-Guardia S, Amati F, Aliberti S, Masclans JR, Soni N, Rodriguez A, Sibila O, Sanz F, Sotgiu G, Anzueto A, Dimakou K, Petrino R, van de Garde E, Restrepo MI; GLIMP investigators
Chest 2021 Jan;159(1):58-72. Epub 2020 Jul 17 doi: 10.1016/j.chest.2020.06.079. PMID: 32687909
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Nakano S, Sun L, Fulcher ML, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O'Neal WK, Randell SH, Boucher RC, Baric RS
Cell 2020 Jul 23;182(2):429-446.e14. Epub 2020 May 27 doi: 10.1016/j.cell.2020.05.042. PMID: 32526206Free PMC Article
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678
Pediatric Dysphagia: Physiology, Assessment, and Management.
Dodrill P, Gosa MM
Ann Nutr Metab 2015;66 Suppl 5:24-31. Epub 2015 Jul 24 doi: 10.1159/000381372. PMID: 26226994

Therapy

Open and Closed Endotracheal Suction Systems Divergently Affect Pulmonary Function in Mechanically Ventilated Subjects.
Raimundo RD, Sato MA, da Silva TD, de Abreu LC, Valenti VE, Riggs DW, Perrow Carll A
Respir Care 2021 May;66(5):785-792. Epub 2021 Mar 9 doi: 10.4187/respcare.08511. PMID: 33688090
Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia.
Marin-Corral J, Pascual-Guardia S, Amati F, Aliberti S, Masclans JR, Soni N, Rodriguez A, Sibila O, Sanz F, Sotgiu G, Anzueto A, Dimakou K, Petrino R, van de Garde E, Restrepo MI; GLIMP investigators
Chest 2021 Jan;159(1):58-72. Epub 2020 Jul 17 doi: 10.1016/j.chest.2020.06.079. PMID: 32687909
Chronic Cough.
Pacheco A, de Diego A, Domingo C, Lamas A, Gutierrez R, Naberan K, Garrigues V, López Vime R
Arch Bronconeumol 2015 Nov;51(11):579-89. Epub 2015 Jul 10 doi: 10.1016/j.arbres.2015.03.019. PMID: 26165783
Nasal congestion in infants and children: a literature review on efficacy and safety of non-pharmacological treatments.
Chirico G, Quartarone G, Mallefet P
Minerva Pediatr 2014 Dec;66(6):549-57. PMID: 25336097
Pathophysiology of pneumonia.
Alcón A, Fàbregas N, Torres A
Clin Chest Med 2005 Mar;26(1):39-46. doi: 10.1016/j.ccm.2004.10.013. PMID: 15802164

Prognosis

Aspiration syndromes and associated lung injury: incidence, pathophysiology and management.
Košutova P, Mikolka P
Physiol Res 2021 Dec 30;70(Suppl4):S567-S583. doi: 10.33549/physiolres.934767. PMID: 35199544Free PMC Article
Laryngeal cleft: evaluation and management.
Johnston DR, Watters K, Ferrari LR, Rahbar R
Int J Pediatr Otorhinolaryngol 2014 Jun;78(6):905-11. Epub 2014 Mar 27 doi: 10.1016/j.ijporl.2014.03.015. PMID: 24735606
Dysphagia and aspiration in children.
Tutor JD, Gosa MM
Pediatr Pulmonol 2012 Apr;47(4):321-37. Epub 2011 Oct 18 doi: 10.1002/ppul.21576. PMID: 22009835
Laryngo-tracheo-oesophageal clefts.
Leboulanger N, Garabédian EN
Orphanet J Rare Dis 2011 Dec 7;6:81. doi: 10.1186/1750-1172-6-81. PMID: 22151899Free PMC Article
Aspiration-induced lung injury.
Raghavendran K, Nemzek J, Napolitano LM, Knight PR
Crit Care Med 2011 Apr;39(4):818-26. doi: 10.1097/CCM.0b013e31820a856b. PMID: 21263315Free PMC Article

Clinical prediction guides

Infant aspiration and associated signs on clinical feeding evaluation.
Balest AL, Mahoney AS, Shaffer AD, White KE, Theiss R, Dohar J
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110856. Epub 2021 Jul 28 doi: 10.1016/j.ijporl.2021.110856. PMID: 34358815
Nasal congestion in infants and children: a literature review on efficacy and safety of non-pharmacological treatments.
Chirico G, Quartarone G, Mallefet P
Minerva Pediatr 2014 Dec;66(6):549-57. PMID: 25336097
Aspiration-induced lung injury.
Raghavendran K, Nemzek J, Napolitano LM, Knight PR
Crit Care Med 2011 Apr;39(4):818-26. doi: 10.1097/CCM.0b013e31820a856b. PMID: 21263315Free PMC Article
Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial.
Troche MS, Okun MS, Rosenbek JC, Musson N, Fernandez HH, Rodriguez R, Romrell J, Pitts T, Wheeler-Hegland KM, Sapienza CM
Neurology 2010 Nov 23;75(21):1912-9. doi: 10.1212/WNL.0b013e3181fef115. PMID: 21098406Free PMC Article
Dysphagia bedside screening for acute-stroke patients: the Gugging Swallowing Screen.
Trapl M, Enderle P, Nowotny M, Teuschl Y, Matz K, Dachenhausen A, Brainin M
Stroke 2007 Nov;38(11):2948-52. Epub 2007 Sep 20 doi: 10.1161/STROKEAHA.107.483933. PMID: 17885261

Recent systematic reviews

Accuracy of upper respiratory tract samples to diagnose Mycobacterium tuberculosis: a systematic review and meta-analysis.
Savage HR, Rickman HM, Burke RM, Odland ML, Savio M, Ringwald B, Cuevas LE, MacPherson P
Lancet Microbe 2023 Oct;4(10):e811-e821. Epub 2023 Sep 12 doi: 10.1016/S2666-5247(23)00190-8. PMID: 37714173Free PMC Article
Pediatric Respiratory Syncytial Virus Diagnostic Testing Performance: A Systematic Review and Meta-analysis.
Onwuchekwa C, Atwell J, Moreo LM, Menon S, Machado B, Siapka M, Agarwal N, Rubbrecht M, Aponte-Torres Z, Rozenbaum M, Curcio D, Nair H, Kalina WV, Vroling H, Gessner B, Begier E
J Infect Dis 2023 Nov 28;228(11):1516-1527. doi: 10.1093/infdis/jiad185. PMID: 37285396Free PMC Article
Respiratory care in familial dysautonomia: Systematic review and expert consensus recommendations.
Kazachkov M, Palma JA, Norcliffe-Kaufmann L, Bar-Aluma BE, Spalink CL, Barnes EP, Amoroso NE, Balou SM, Bess S, Chopra A, Condos R, Efrati O, Fitzgerald K, Fridman D, Goldenberg RM, Goldhaber A, Kaufman DA, Kothare SV, Levine J, Levy J, Lubinsky AS, Maayan C, Moy LC, Rivera PJ, Rodriguez AJ, Sokol G, Sloane MF, Tan T, Kaufmann H
Respir Med 2018 Aug;141:37-46. Epub 2018 Jun 21 doi: 10.1016/j.rmed.2018.06.017. PMID: 30053970Free PMC Article
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678
Ingested and Aspirated Foreign Bodies.
Green SS
Pediatr Rev 2015 Oct;36(10):430-6; quiz 437. doi: 10.1542/pir.36-10-430. PMID: 26430203

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