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Genital herpes

MedGen UID:
42436
•Concept ID:
C0019342
•
Disease or Syndrome
Synonyms: Genital Herpes; Genital Herpes Simplex; Herpes Genitalis; Herpes Simplex Virus Genital Infection; Herpes Simplex, Genital; Herpes, Genital
SNOMED CT: Genital herpes simplex (33839006); Herpes genitalis (33839006)
 
Monarch Initiative: MONDO:0005770

Definition

Herpes simplex infection of the genitals, most commonly caused by the herpes simplex-2 virus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenital herpes

Professional guidelines

PubMed

Diagnosis and Treatment of Sexually Transmitted Infections: A Review.
Tuddenham S, Hamill MM, Ghanem KG
JAMA 2022 Jan 11;327(2):161-172. doi: 10.1001/jama.2021.23487. PMID: 35015033
Sexually Transmitted Infections Treatment Guidelines, 2021.
Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, Reno H, Zenilman JM, Bolan GA
MMWR Recomm Rep 2021 Jul 23;70(4):1-187. doi: 10.15585/mmwr.rr7004a1. PMID: 34292926Free PMC Article
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

Recent clinical studies

Etiology

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes.
Polansky H, Javaherian A, Itzkovitz E
J Evid Based Integr Med 2018 Jan-Dec;23:2515690X18806269. doi: 10.1177/2515690X18806269. PMID: 30362389Free PMC Article
Genital Herpes: A Review.
Groves MJ
Am Fam Physician 2016 Jun 1;93(11):928-34. PMID: 27281837
Genital herpes.
Gupta R, Warren T, Wald A
Lancet 2007 Dec 22;370(9605):2127-37. doi: 10.1016/S0140-6736(07)61908-4. PMID: 18156035

Diagnosis

Genital Herpes Infection: Progress and Problems.
Van Wagoner N, Qushair F, Johnston C
Infect Dis Clin North Am 2023 Jun;37(2):351-367. doi: 10.1016/j.idc.2023.02.011. PMID: 37105647
Genital Herpes Simplex Virus-An Updated Review.
Omarova S, Cannon A, Weiss W, Bruccoleri A, Puccio J
Adv Pediatr 2022 Aug;69(1):149-162. Epub 2022 Jun 21 doi: 10.1016/j.yapd.2022.03.010. PMID: 35985707
Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment.
Cole S
Nurs Clin North Am 2020 Sep;55(3):337-345. Epub 2020 Jul 15 doi: 10.1016/j.cnur.2020.05.004. PMID: 32762854
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Genital Herpes: A Review.
Groves MJ
Am Fam Physician 2016 Jun 1;93(11):928-34. PMID: 27281837

Therapy

Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes.
Polansky H, Javaherian A, Itzkovitz E
J Evid Based Integr Med 2018 Jan-Dec;23:2515690X18806269. doi: 10.1177/2515690X18806269. PMID: 30362389Free PMC Article
2017 European guidelines for the management of genital herpes.
Patel R, Kennedy OJ, Clarke E, Geretti A, Nilsen A, Lautenschlager S, Green J, Donders G, van der Meijden W, Gomberg M, Moi H, Foley E
Int J STD AIDS 2017 Dec;28(14):1366-1379. Epub 2017 Aug 24 doi: 10.1177/0956462417727194. PMID: 28836892
Genital Herpes: A Review.
Groves MJ
Am Fam Physician 2016 Jun 1;93(11):928-34. PMID: 27281837
Genital herpes.
Gupta R, Warren T, Wald A
Lancet 2007 Dec 22;370(9605):2127-37. doi: 10.1016/S0140-6736(07)61908-4. PMID: 18156035
Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications.
Gnann JW Jr, Barton NH, Whitley RJ
Pharmacotherapy 1983 Sep-Oct;3(5):275-83. doi: 10.1002/j.1875-9114.1983.tb03274.x. PMID: 6359082

Prognosis

Global, regional, and national burdens of HIV and other sexually transmitted infections in adolescents and young adults aged 10-24 years from 1990 to 2019: a trend analysis based on the Global Burden of Disease Study 2019.
Zhang J, Ma B, Han X, Ding S, Li Y
Lancet Child Adolesc Health 2022 Nov;6(11):763-776. Epub 2022 Sep 13 doi: 10.1016/S2352-4642(22)00219-X. PMID: 36108664
40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Global burden and trends of sexually transmitted infections from 1990 to 2019: an observational trend study.
Zheng Y, Yu Q, Lin Y, Zhou Y, Lan L, Yang S, Wu J
Lancet Infect Dis 2022 Apr;22(4):541-551. Epub 2021 Dec 20 doi: 10.1016/S1473-3099(21)00448-5. PMID: 34942091
Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2018.
Kreisel KM, Spicknall IH, Gargano JW, Lewis FMT, Lewis RM, Markowitz LE, Roberts H, Johnson AS, Song R, St Cyr SB, Weston EJ, Torrone EA, Weinstock HS
Sex Transm Dis 2021 Apr 1;48(4):208-214. doi: 10.1097/OLQ.0000000000001355. PMID: 33492089Free PMC Article
Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article

Clinical prediction guides

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Diagnosis and Treatment of Sexually Transmitted Infections: A Review.
Tuddenham S, Hamill MM, Ghanem KG
JAMA 2022 Jan 11;327(2):161-172. doi: 10.1001/jama.2021.23487. PMID: 35015033
Global burden and trends of sexually transmitted infections from 1990 to 2019: an observational trend study.
Zheng Y, Yu Q, Lin Y, Zhou Y, Lan L, Yang S, Wu J
Lancet Infect Dis 2022 Apr;22(4):541-551. Epub 2021 Dec 20 doi: 10.1016/S1473-3099(21)00448-5. PMID: 34942091
Pathogenesis and virulence of herpes simplex virus.
Zhu S, Viejo-Borbolla A
Virulence 2021 Dec;12(1):2670-2702. doi: 10.1080/21505594.2021.1982373. PMID: 34676800Free PMC Article
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

Recent systematic reviews

Health-related quality of life in individuals with genital herpes: a systematic review.
Devine A, Xiong X, Gottlieb SL, de Mello MB, Fairley CK, Ong JJ
Health Qual Life Outcomes 2022 Feb 16;20(1):25. doi: 10.1186/s12955-022-01934-w. PMID: 35172828Free PMC Article
Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Feltner C, Grodensky C, Ebel C, Middleton JC, Harris RP, Ashok M, Jonas DE
JAMA 2016 Dec 20;316(23):2531-2543. doi: 10.1001/jama.2016.17138. PMID: 27997660
Genital herpes: oral antiviral treatments.
Hollier LM, Eppes C
BMJ Clin Evid 2015 Apr 8;2015 PMID: 25853497Free PMC Article
Genital herpes.
Hollier LM, Straub H
BMJ Clin Evid 2011 Apr 15;2011 PMID: 21496359Free PMC Article
Genital herpes.
Jungmann EM
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454063Free PMC Article

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