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Microvascular complications of diabetes, susceptibility to, 5(MVCD5)

MedGen UID:
436225
•Concept ID:
C2674665
•
Finding
Synonyms: Microvascular complications of diabetes 5; RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO
 
Gene (location): PON1 (7q21.3)
 
Monarch Initiative: MONDO:0012969
OMIM®: 612633

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the PON1 gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
The genetics of diabetic complications.
Ahlqvist E, van Zuydam NR, Groop LC, McCarthy MI
Nat Rev Nephrol 2015 May;11(5):277-87. Epub 2015 Mar 31 doi: 10.1038/nrneph.2015.37. PMID: 25825086
Diabetes and associated complications in the South Asian population.
Shah A, Kanaya AM
Curr Cardiol Rep 2014 May;16(5):476. doi: 10.1007/s11886-014-0476-5. PMID: 24643902Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Diagnosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Perspectives on systems biology applications in diabetic kidney disease.
Komorowsky CV, Brosius FC 3rd, Pennathur S, Kretzler M
J Cardiovasc Transl Res 2012 Aug;5(4):491-508. Epub 2012 Jun 26 doi: 10.1007/s12265-012-9382-7. PMID: 22733404Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980
Chromosome 7q35 and susceptibility to diabetic microvascular complications.
Patel A, Hibberd ML, Millward BA, Demaine AG
J Diabetes Complications 1996 Mar-Apr;10(2):62-7. doi: 10.1016/1056-8727(95)00004-6. PMID: 8777332

Prognosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients.
Mattishent K, Loke YK
J Diabetes Complications 2016 Jul;30(5):811-8. Epub 2016 Mar 17 doi: 10.1016/j.jdiacomp.2016.03.018. PMID: 27083445
Perspectives on systems biology applications in diabetic kidney disease.
Komorowsky CV, Brosius FC 3rd, Pennathur S, Kretzler M
J Cardiovasc Transl Res 2012 Aug;5(4):491-508. Epub 2012 Jun 26 doi: 10.1007/s12265-012-9382-7. PMID: 22733404Free PMC Article
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Clinical prediction guides

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran.
Alidoust L, Ajamian F, Abbaspour S, Sharafshah A, Keshavarz P
Br J Biomed Sci 2022;79:10245. Epub 2022 Apr 22 doi: 10.3389/bjbs.2021.10245. PMID: 35996512Free PMC Article
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients.
Mattishent K, Loke YK
J Diabetes Complications 2016 Jul;30(5):811-8. Epub 2016 Mar 17 doi: 10.1016/j.jdiacomp.2016.03.018. PMID: 27083445
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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      OMIM records containing genes associated with phenotypes registered in MedGen
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