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Epiphysiolysis

MedGen UID:: 4510
•Concept ID:: C0014571
•: Disease or Syndrome

Synonyms:

Epiphyses, Slipped; Epiphysiolyses; Slipped Epiphyses

Definition

Abnormal separation of an epiphysis from the shaft of a bone. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEpiphysiolysis

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Musculoskeletal system disorder
        Disorder of bone
        Epiphysiolysis
        Proximal femoral epiphysiolysis

Professional guidelines

PubMed

Early GH Treatment Is Effective and Well Tolerated in Children With Turner Syndrome: NordiNet® IOS and Answer Program.

Backeljauw P, Blair JC, Ferran JM, Kelepouris N, Miller BS, Pietropoli A, Polak M, Sävendahl L, Verlinde F, Rohrer TR
J Clin Endocrinol Metab 2023 Sep 18;108(10):2653-2665. doi: 10.1210/clinem/dgad159. PMID: 36947589 Free PMC Article

Trends in the Presentation, Management, and Outcomes of Little League Shoulder.

Heyworth BE, Kramer DE, Martin DJ, Micheli LJ, Kocher MS, Bae DS
Am J Sports Med 2016 Jun;44(6):1431-8. Epub 2016 Mar 16 doi: 10.1177/0363546516632744. PMID: 26983458

Southwick's angle determination during growth hormone treatment and its usefulness to evaluate risk of epiphysiolysis.

de Andrade AC, Longui CA, Damasceno FL, Santili C
J Pediatr Orthop B 2009 Jan;18(1):11-5. doi: 10.1097/BPB.0b013e328318c6f3. PMID: 19436244

See all (4)

Recent clinical studies

Etiology

The torsion of the proximal femur in cementless total hip arthroplasty: a 3-dimensional evaluation.

Wettstein M, Mouhsine E, Aubaniac JM, Audigé L, Ollivier M, Leyvraz PF, Argenson JN
Hip Int 2023 Mar;33(2):254-261. Epub 2021 Aug 26 doi: 10.1177/11207000211037196. PMID: 34445907

The Feasibility of C1-C2 Screw-rod Fixation in the Children 5 Years of Age and Younger.

Burkhardt BW, Podolski W, Pitzen TR, Ruf M
J Pediatr Orthop 2021 Sep 1;41(8):e651-e658. doi: 10.1097/BPO.0000000000001899. PMID: 34238864

Mechanism and predisposing factors for proximal tibial epiphysiolysis in adolescents during sports activities.

Steiger CN, Ceroni D
Int Orthop 2019 Jun;43(6):1395-1403. Epub 2018 Sep 29 doi: 10.1007/s00264-018-4168-4. PMID: 30267244

Shoulder injuries in the skeletally immature baseball pitcher and recommendations for the prevention of injury.

Zaremski JL, Krabak BJ
PM R 2012 Jul;4(7):509-16. doi: 10.1016/j.pmrj.2012.04.005. PMID: 22814728

Patterns of osteoarthritis of the hip.

Solomon L
J Bone Joint Surg Br 1976 May;58(2):176-83. doi: 10.1302/0301-620X.58B2.932079. PMID: 932079

See all (39)

Diagnosis

Slipped capital femoral epiphysis: Diagnostic pitfalls and therapeutic options.

Panuccio E, Priano D, Caccavella V, Memeo A
Pediatr Med Chir 2022 Oct 28;44(s1) doi: 10.4081/pmc.2022.296. PMID: 37184314

The Feasibility of C1-C2 Screw-rod Fixation in the Children 5 Years of Age and Younger.

Burkhardt BW, Podolski W, Pitzen TR, Ruf M
J Pediatr Orthop 2021 Sep 1;41(8):e651-e658. doi: 10.1097/BPO.0000000000001899. PMID: 34238864

Transphyseal elbow fracture in newborn: review of literature.

Ratti C, Guindani N, Riva G, Callegari L, Grassi FA, Murena L
Musculoskelet Surg 2015 Sep;99 Suppl 1:S99-105. Epub 2015 May 10 doi: 10.1007/s12306-015-0366-z. PMID: 25957551

Hip pathology in Majewski osteodysplastic primordial dwarfism type II.

Karatas AF, Bober MB, Rogers K, Duker AL, Ditro CP, Mackenzie WG
J Pediatr Orthop 2014 Sep;34(6):585-90. doi: 10.1097/BPO.0000000000000183. PMID: 24705347

Upper and lower limb length equalization: diagnosis, limb lengthening and curtailment, epiphysiodesis.

Burnei G, Vlad C, Gavriliu S, Georgescu I, Hodorogea D, Pârvan A, Burnei C, El Nayef T, Drăghici I
Rom J Intern Med 2012 Jan-Mar;50(1):43-59. PMID: 22788093

See all (47)

Therapy

Early GH Treatment Is Effective and Well Tolerated in Children With Turner Syndrome: NordiNet® IOS and Answer Program.

Long-Term Improvement and Safety of Aripiprazole for Irritability and Adaptive Function in Asian Children and Adolescents with Autistic Disorder: A 52-Week, Multinational, Multicenter, Open-Label Study.

Kim BU, Kim HW, Park EJ, Kim JH, Boon-Yasidhi V, Tarugsa J, Reyes A, Manalo SG, Joung YS
J Child Adolesc Psychopharmacol 2022 Sep;32(7):390-399. doi: 10.1089/cap.2022.0004. PMID: 36112116

Effectiveness and Overall Safety of NutropinAq(®) for Growth Hormone Deficiency and Other Paediatric Growth Hormone Disorders: Completion of the International Cooperative Growth Study, NutropinAq(®) European Registry (iNCGS).

Coutant R, Bosch Muñoz J, Dumitrescu CP, Schnabel D, Sert C, Perrot V, Dattani M
Front Endocrinol (Lausanne) 2021;12:676083. Epub 2021 May 25 doi: 10.3389/fendo.2021.676083. PMID: 34113318 Free PMC Article

Adolescent Hip Dislocation Combined With Proximal Femoral Physeal Fractures and Epiphysiolysis.

Kennon JC, Bohsali KI, Ogden JA, Ogden J 3rd, Ganey TM
J Pediatr Orthop 2016 Apr-May;36(3):253-61. doi: 10.1097/BPO.0000000000000433. PMID: 25757209

Epiphyseal distraction. Chondrodiatasis.

Aldegheri R, Trivella G, Lavini F
Clin Orthop Relat Res 1989 Apr;(241):117-27. PMID: 2924455

See all (20)

Prognosis

Slipped capital femoral epiphysis: Diagnostic pitfalls and therapeutic options.

Panuccio E, Priano D, Caccavella V, Memeo A
Pediatr Med Chir 2022 Oct 28;44(s1) doi: 10.4081/pmc.2022.296. PMID: 37184314

Congenital myopathy as a new phenotype caused by two undescribed variants in ASCC1 gene.

Sharova M, Guseva D, Kurenkov A, Novoselova O, Murtazina A, Skoblov M
Am J Med Genet A 2022 Oct;188(10):3100-3105. Epub 2022 Jul 15 doi: 10.1002/ajmg.a.62898. PMID: 35838082

Transphyseal elbow fracture in newborn: review of literature.

Ratti C, Guindani N, Riva G, Callegari L, Grassi FA, Murena L
Musculoskelet Surg 2015 Sep;99 Suppl 1:S99-105. Epub 2015 May 10 doi: 10.1007/s12306-015-0366-z. PMID: 25957551

Osteitis pubis in athletes. Infection, inflammation or injury?

Fricker PA, Taunton JE, Ammann W
Sports Med 1991 Oct;12(4):266-79. doi: 10.2165/00007256-199112040-00005. PMID: 1784877

See all (27)

Clinical prediction guides

Early GH Treatment Is Effective and Well Tolerated in Children With Turner Syndrome: NordiNet® IOS and Answer Program.

Kim BU, Kim HW, Park EJ, Kim JH, Boon-Yasidhi V, Tarugsa J, Reyes A, Manalo SG, Joung YS
J Child Adolesc Psychopharmacol 2022 Sep;32(7):390-399. doi: 10.1089/cap.2022.0004. PMID: 36112116

The role of trauma mechanism, fracture pattern and fixation technique on clinical outcomes and epiphyseal growth arrest in the surgical treatment of distal tibial epiphysiolysis.

Aslantaş FÇ, Yalın M, İlter MH, Bayrak A, Edipoğlu E, Tanrıverdi B, Duramaz A, Bilgili MG
Ulus Travma Acil Cerrahi Derg 2020 May;26(3):425-430. doi: 10.14744/tjtes.2019.27354. PMID: 32436969

Southwick's head-shaft angles: normal standards and abnormal values observed in obesity and in patients with epiphysiolysis.

Santili C, de Assis MC, Kusabara FI, Romero IL, Sartini CM, Longui CA
J Pediatr Orthop B 2004 Jul;13(4):244-7. doi: 10.1097/01.bpb.0000111042.46580.68. PMID: 15199279

See all (17)

Recent systematic reviews

Mechanism and predisposing factors for proximal tibial epiphysiolysis in adolescents during sports activities.

Steiger CN, Ceroni D
Int Orthop 2019 Jun;43(6):1395-1403. Epub 2018 Sep 29 doi: 10.1007/s00264-018-4168-4. PMID: 30267244

See all (1)

MedGen

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Epiphysiolysis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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