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Schizophrenia and Other Psychotic Disorders

MedGen UID:
452302
•Concept ID:
C0236988
•
Mental or Behavioral Dysfunction

Definition

A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening. [from NCI]

Professional guidelines

PubMed

Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.
Kaar SJ, Natesan S, McCutcheon R, Howes OD
Neuropharmacology 2020 Aug 1;172:107704. Epub 2019 Jul 9 doi: 10.1016/j.neuropharm.2019.107704. PMID: 31299229
ABCB1 and CYP2D6 polymorphisms and treatment response of psychotic patients in a naturalistic setting.
Papazisis G, Goulas A, Sarrigiannidis A, Bargiota S, Antoniadis D, Raikos N, Basgiouraki E, Bozikas VP, Garyfallos G
Hum Psychopharmacol 2018 Jan;33(1) Epub 2017 Dec 18 doi: 10.1002/hup.2644. PMID: 29250824
Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders.
Dold M, Samara MT, Li C, Tardy M, Leucht S
Cochrane Database Syst Rev 2015 Jan 16;1(1):CD009831. doi: 10.1002/14651858.CD009831.pub2. PMID: 25592299Free PMC Article

Recent clinical studies

Etiology

Childhood adversity and psychotic disorders: Epidemiological evidence, theoretical models and clinical considerations.
Rosenfield PJ, Jiang D, Pauselli L
Schizophr Res 2022 Sep;247:55-66. Epub 2021 Jun 28 doi: 10.1016/j.schres.2021.06.005. PMID: 34210561
Effect of child abuse and neglect on schizophrenia and other psychotic disorders.
Chaiyachati BH, Gur RE
Pharmacol Biochem Behav 2021 Jul;206:173195. Epub 2021 May 5 doi: 10.1016/j.pbb.2021.173195. PMID: 33961909Free PMC Article
Psychiatric disorders in women with polycystic ovary syndrome.
Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, Głowińska A, Spaczyński R, Rybakowski F, Pawełczyk L, Banaszewska B
Psychiatr Pol 2019 Aug 31;53(4):955-966. doi: 10.12740/PP/OnlineFirst/93105. PMID: 31760419
Prevalence of mental disorders in China: a cross-sectional epidemiological study.
Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J, Yu Y, Kou C, Xu X, Lu J, Wang Z, He S, Xu Y, He Y, Li T, Guo W, Tian H, Xu G, Xu X, Ma Y, Wang L, Wang L, Yan Y, Wang B, Xiao S, Zhou L, Li L, Tan L, Zhang T, Ma C, Li Q, Ding H, Geng H, Jia F, Shi J, Wang S, Zhang N, Du X, Du X, Wu Y
Lancet Psychiatry 2019 Mar;6(3):211-224. Epub 2019 Feb 18 doi: 10.1016/S2215-0366(18)30511-X. PMID: 30792114
Obstructive sleep apnea and psychiatric disorders: a systematic review.
Gupta MA, Simpson FC
J Clin Sleep Med 2015 Jan 15;11(2):165-75. doi: 10.5664/jcsm.4466. PMID: 25406268Free PMC Article

Diagnosis

The prevalence of schizophrenia and other psychotic disorders among homeless people: a systematic review and meta-analysis.
Ayano G, Tesfaw G, Shumet S
BMC Psychiatry 2019 Nov 27;19(1):370. doi: 10.1186/s12888-019-2361-7. PMID: 31775786Free PMC Article
Psychiatric disorders in women with polycystic ovary syndrome.
Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, Głowińska A, Spaczyński R, Rybakowski F, Pawełczyk L, Banaszewska B
Psychiatr Pol 2019 Aug 31;53(4):955-966. doi: 10.12740/PP/OnlineFirst/93105. PMID: 31760419
Prevalence of mental disorders in China: a cross-sectional epidemiological study.
Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J, Yu Y, Kou C, Xu X, Lu J, Wang Z, He S, Xu Y, He Y, Li T, Guo W, Tian H, Xu G, Xu X, Ma Y, Wang L, Wang L, Yan Y, Wang B, Xiao S, Zhou L, Li L, Tan L, Zhang T, Ma C, Li Q, Ding H, Geng H, Jia F, Shi J, Wang S, Zhang N, Du X, Du X, Wu Y
Lancet Psychiatry 2019 Mar;6(3):211-224. Epub 2019 Feb 18 doi: 10.1016/S2215-0366(18)30511-X. PMID: 30792114
Obstructive sleep apnea and psychiatric disorders: a systematic review.
Gupta MA, Simpson FC
J Clin Sleep Med 2015 Jan 15;11(2):165-75. doi: 10.5664/jcsm.4466. PMID: 25406268Free PMC Article
Culture and schizophrenia and other psychotic disorders.
Kulhara P, Chakrabarti S
Psychiatr Clin North Am 2001 Sep;24(3):449-64. doi: 10.1016/s0193-953x(05)70240-9. PMID: 11593856

Therapy

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.
Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC
Am J Psychiatry 2022 Sep;179(9):611-627. Epub 2022 Jun 27 doi: 10.1176/appi.ajp.21101083. PMID: 35758639
Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.
Kaar SJ, Natesan S, McCutcheon R, Howes OD
Neuropharmacology 2020 Aug 1;172:107704. Epub 2019 Jul 9 doi: 10.1016/j.neuropharm.2019.107704. PMID: 31299229
The prevalence of schizophrenia and other psychotic disorders among homeless people: a systematic review and meta-analysis.
Ayano G, Tesfaw G, Shumet S
BMC Psychiatry 2019 Nov 27;19(1):370. doi: 10.1186/s12888-019-2361-7. PMID: 31775786Free PMC Article
Switch-associated adverse events: focus on olanzapine.
Xu L, Krishnaswamy S
Australas Psychiatry 2018 Dec;26(6):635-639. Epub 2018 Nov 8 doi: 10.1177/1039856218810166. PMID: 30407073
Environmental pollution and risk of psychotic disorders: A review of the science to date.
Attademo L, Bernardini F, Garinella R, Compton MT
Schizophr Res 2017 Mar;181:55-59. Epub 2016 Oct 6 doi: 10.1016/j.schres.2016.10.003. PMID: 27720315

Prognosis

Viewpoint: do antipsychotics protect against early death? A critical view.
Whitaker R
Psychol Med 2020 Dec;50(16):2643-2652. Epub 2020 Oct 14 doi: 10.1017/S003329172000358X. PMID: 33050955
Suicidal behavior and mortality in first-episode psychosis.
Nordentoft M, Madsen T, Fedyszyn I
J Nerv Ment Dis 2015 May;203(5):387-92. doi: 10.1097/NMD.0000000000000296. PMID: 25919385
Schizophrenia and other psychotic disorders in Caribbean-born migrants and their descendants in England: systematic review and meta-analysis of incidence rates, 1950-2013.
Tortelli A, Errazuriz A, Croudace T, Morgan C, Murray RM, Jones PB, Szoke A, Kirkbride JB
Soc Psychiatry Psychiatr Epidemiol 2015 Jul;50(7):1039-55. Epub 2015 Feb 7 doi: 10.1007/s00127-015-1021-6. PMID: 25660551Free PMC Article
The development of psychotic disorders in adolescence: a potential role for hormones.
Trotman HD, Holtzman CW, Ryan AT, Shapiro DI, MacDonald AN, Goulding SM, Brasfield JL, Walker EF
Horm Behav 2013 Jul;64(2):411-9. doi: 10.1016/j.yhbeh.2013.02.018. PMID: 23998682Free PMC Article
Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders.
Sikich L
J Clin Psychiatry 2008;69 Suppl 4:21-5. PMID: 18533765

Clinical prediction guides

The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders.
Alkelai A, Greenbaum L, Docherty AR, Shabalin AA, Povysil G, Malakar A, Hughes D, Delaney SL, Peabody EP, McNamara J, Gelfman S, Baugh EH, Zoghbi AW, Harms MB, Hwang HS, Grossman-Jonish A, Aggarwal V, Heinzen EL, Jobanputra V, Pulver AE, Lerer B, Goldstein DB
Mol Psychiatry 2022 Mar;27(3):1435-1447. Epub 2021 Nov 19 doi: 10.1038/s41380-021-01383-9. PMID: 34799694
Psychiatric disorders in women with polycystic ovary syndrome.
Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, Głowińska A, Spaczyński R, Rybakowski F, Pawełczyk L, Banaszewska B
Psychiatr Pol 2019 Aug 31;53(4):955-966. doi: 10.12740/PP/OnlineFirst/93105. PMID: 31760419
Toxicology and overdose of atypical antipsychotics.
Minns AB, Clark RF
J Emerg Med 2012 Nov;43(5):906-13. Epub 2012 May 1 doi: 10.1016/j.jemermed.2012.03.002. PMID: 22555052
Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders.
Sikich L
J Clin Psychiatry 2008;69 Suppl 4:21-5. PMID: 18533765
Boundaries of schizophrenia.
Adler CM, Strakowski SM
Psychiatr Clin North Am 2003 Mar;26(1):1-23. doi: 10.1016/s0193-953x(02)00085-0. PMID: 12683257

Recent systematic reviews

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.
Smigielski L, Jagannath V, Rössler W, Walitza S, Grünblatt E
Mol Psychiatry 2020 Aug;25(8):1718-1748. Epub 2020 Jan 6 doi: 10.1038/s41380-019-0601-3. PMID: 31907379
The prevalence of schizophrenia and other psychotic disorders among homeless people: a systematic review and meta-analysis.
Ayano G, Tesfaw G, Shumet S
BMC Psychiatry 2019 Nov 27;19(1):370. doi: 10.1186/s12888-019-2361-7. PMID: 31775786Free PMC Article
Schizophrenia and other psychotic disorders in Caribbean-born migrants and their descendants in England: systematic review and meta-analysis of incidence rates, 1950-2013.
Tortelli A, Errazuriz A, Croudace T, Morgan C, Murray RM, Jones PB, Szoke A, Kirkbride JB
Soc Psychiatry Psychiatr Epidemiol 2015 Jul;50(7):1039-55. Epub 2015 Feb 7 doi: 10.1007/s00127-015-1021-6. PMID: 25660551Free PMC Article
Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders.
Dold M, Samara MT, Li C, Tardy M, Leucht S
Cochrane Database Syst Rev 2015 Jan 16;1(1):CD009831. doi: 10.1002/14651858.CD009831.pub2. PMID: 25592299Free PMC Article
Obstructive sleep apnea and psychiatric disorders: a systematic review.
Gupta MA, Simpson FC
J Clin Sleep Med 2015 Jan 15;11(2):165-75. doi: 10.5664/jcsm.4466. PMID: 25406268Free PMC Article

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