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Death rattle

MedGen UID:
452600
•Concept ID:
C0547002
•
Sign or Symptom
Synonym: Death Rattle
SNOMED CT: Death rattle (271622006)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeath rattle

Professional guidelines

PubMed

Clinical practice guideline for end-of-life care in patients with cancer: a modified ADAPTE process.
Irajpour A, Hashemi M, Taleghani F
Support Care Cancer 2022 Mar;30(3):2497-2505. Epub 2021 Nov 16 doi: 10.1007/s00520-021-06558-2. PMID: 34786639
Prevalence, impact, and treatment of death rattle: a systematic review.
Lokker ME, van Zuylen L, van der Rijt CC, van der Heide A
J Pain Symptom Manage 2014 Jan;47(1):105-22. Epub 2013 Jun 18 doi: 10.1016/j.jpainsymman.2013.03.011. PMID: 23790419
Management of death rattle at end of life.
Twomey S, Dowling M
Br J Nurs 2013 Jan 24-Feb 13;22(2):81-5. doi: 10.12968/bjon.2013.22.2.81. PMID: 23587890

Recent clinical studies

Etiology

Effects of Anticholinergics on Death Rattle: A Systematic Review and Network Meta-Analysis.
Taburee W, Dhippayom T, Nagaviroj K, Dilokthornsakul P
J Palliat Med 2023 Mar;26(3):431-440. Epub 2022 Oct 3 doi: 10.1089/jpm.2022.0386. PMID: 36194053
The impact of death rattle on bereaved families: not the sound itself, but the resonance with their feelings.
Yamaguchi T, Mori M, Maeda I, Matsunuma R, Tanaka-Yagi Y, Nishi T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M
Jpn J Clin Oncol 2022 Jul 8;52(7):774-778. doi: 10.1093/jjco/hyac055. PMID: 35446952
Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial.
van Esch HJ, van Zuylen L, Geijteman ECT, Oomen-de Hoop E, Huisman BAA, Noordzij-Nooteboom HS, Boogaard R, van der Heide A, van der Rijt CCD
JAMA 2021 Oct 5;326(13):1268-1276. doi: 10.1001/jama.2021.14785. PMID: 34609452Free PMC Article
When they stop drinking-examining end-of-life hydration practices and death rattle occurrence.
Dayan D, Menahem S, Shvartzman P
Support Care Cancer 2021 Jan;29(1):179-185. Epub 2020 Apr 23 doi: 10.1007/s00520-020-05470-5. PMID: 32328774
Prevalence, impact, and treatment of death rattle: a systematic review.
Lokker ME, van Zuylen L, van der Rijt CC, van der Heide A
J Pain Symptom Manage 2014 Jan;47(1):105-22. Epub 2013 Jun 18 doi: 10.1016/j.jpainsymman.2013.03.011. PMID: 23790419

Diagnosis

Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial.
van Esch HJ, van Zuylen L, Geijteman ECT, Oomen-de Hoop E, Huisman BAA, Noordzij-Nooteboom HS, Boogaard R, van der Heide A, van der Rijt CCD
JAMA 2021 Oct 5;326(13):1268-1276. doi: 10.1001/jama.2021.14785. PMID: 34609452Free PMC Article
Death rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice.
Watts T, Willis D, Noble S, Johnston B
Curr Opin Support Palliat Care 2019 Dec;13(4):380-383. doi: 10.1097/SPC.0000000000000463. PMID: 31567520
Clinical signs of impending death in cancer patients.
Hui D, dos Santos R, Chisholm G, Bansal S, Silva TB, Kilgore K, Crovador CS, Yu X, Swartz MD, Perez-Cruz PE, Leite Rde A, Nascimento MS, Reddy S, Seriaco F, Yennu S, Paiva CE, Dev R, Hall S, Fajardo J, Bruera E
Oncologist 2014 Jun;19(6):681-7. Epub 2014 Apr 23 doi: 10.1634/theoncologist.2013-0457. PMID: 24760709Free PMC Article
Should we rescue patients with the death rattle?
Manthous CA
Crit Care Med 2013 Oct;41(10):2430-2. doi: 10.1097/CCM.0b013e318298a442. PMID: 23939360
Understanding and responding to the death rattle in dying patients.
Hipp B, Letizia M
Medsurg Nurs 2009 Jan-Feb;18(1):17-21, 32; quiz 22. PMID: 19331295

Therapy

Effects of Anticholinergics on Death Rattle: A Systematic Review and Network Meta-Analysis.
Taburee W, Dhippayom T, Nagaviroj K, Dilokthornsakul P
J Palliat Med 2023 Mar;26(3):431-440. Epub 2022 Oct 3 doi: 10.1089/jpm.2022.0386. PMID: 36194053
Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial.
van Esch HJ, van Zuylen L, Geijteman ECT, Oomen-de Hoop E, Huisman BAA, Noordzij-Nooteboom HS, Boogaard R, van der Heide A, van der Rijt CCD
JAMA 2021 Oct 5;326(13):1268-1276. doi: 10.1001/jama.2021.14785. PMID: 34609452Free PMC Article
Death rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice.
Watts T, Willis D, Noble S, Johnston B
Curr Opin Support Palliat Care 2019 Dec;13(4):380-383. doi: 10.1097/SPC.0000000000000463. PMID: 31567520
Death rattle: critical review and research agenda.
Mercadamte S
Support Care Cancer 2014 Feb;22(2):571-5. Epub 2013 Nov 20 doi: 10.1007/s00520-013-2047-5. PMID: 24253734
Prevalence, impact, and treatment of death rattle: a systematic review.
Lokker ME, van Zuylen L, van der Rijt CC, van der Heide A
J Pain Symptom Manage 2014 Jan;47(1):105-22. Epub 2013 Jun 18 doi: 10.1016/j.jpainsymman.2013.03.011. PMID: 23790419

Prognosis

Management of Physical Symptoms in Patients with Advanced Cancer during the Last Weeks and Days of Life.
Azhar A, Hui D
Cancer Res Treat 2022 Jul;54(3):661-670. Epub 2022 Jun 30 doi: 10.4143/crt.2022.143. PMID: 35790195Free PMC Article
The impact of death rattle on bereaved families: not the sound itself, but the resonance with their feelings.
Yamaguchi T, Mori M, Maeda I, Matsunuma R, Tanaka-Yagi Y, Nishi T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M
Jpn J Clin Oncol 2022 Jul 8;52(7):774-778. doi: 10.1093/jjco/hyac055. PMID: 35446952
Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial.
van Esch HJ, van Zuylen L, Geijteman ECT, Oomen-de Hoop E, Huisman BAA, Noordzij-Nooteboom HS, Boogaard R, van der Heide A, van der Rijt CCD
JAMA 2021 Oct 5;326(13):1268-1276. doi: 10.1001/jama.2021.14785. PMID: 34609452Free PMC Article
Death rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice.
Watts T, Willis D, Noble S, Johnston B
Curr Opin Support Palliat Care 2019 Dec;13(4):380-383. doi: 10.1097/SPC.0000000000000463. PMID: 31567520
Management of death rattle at end of life.
Twomey S, Dowling M
Br J Nurs 2013 Jan 24-Feb 13;22(2):81-5. doi: 10.12968/bjon.2013.22.2.81. PMID: 23587890

Clinical prediction guides

Effects of Anticholinergics on Death Rattle: A Systematic Review and Network Meta-Analysis.
Taburee W, Dhippayom T, Nagaviroj K, Dilokthornsakul P
J Palliat Med 2023 Mar;26(3):431-440. Epub 2022 Oct 3 doi: 10.1089/jpm.2022.0386. PMID: 36194053
The impact of death rattle on bereaved families: not the sound itself, but the resonance with their feelings.
Yamaguchi T, Mori M, Maeda I, Matsunuma R, Tanaka-Yagi Y, Nishi T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M
Jpn J Clin Oncol 2022 Jul 8;52(7):774-778. doi: 10.1093/jjco/hyac055. PMID: 35446952
Hydration and symptoms in the last days of life.
Lokker ME, van der Heide A, Oldenmenger WH, van der Rijt CCD, van Zuylen L
BMJ Support Palliat Care 2021 Sep;11(3):335-343. Epub 2019 Aug 31 doi: 10.1136/bmjspcare-2018-001729. PMID: 31473651Free PMC Article
Death rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice.
Watts T, Willis D, Noble S, Johnston B
Curr Opin Support Palliat Care 2019 Dec;13(4):380-383. doi: 10.1097/SPC.0000000000000463. PMID: 31567520
Death rattle: critical review and research agenda.
Mercadamte S
Support Care Cancer 2014 Feb;22(2):571-5. Epub 2013 Nov 20 doi: 10.1007/s00520-013-2047-5. PMID: 24253734

Recent systematic reviews

Effects of Anticholinergics on Death Rattle: A Systematic Review and Network Meta-Analysis.
Taburee W, Dhippayom T, Nagaviroj K, Dilokthornsakul P
J Palliat Med 2023 Mar;26(3):431-440. Epub 2022 Oct 3 doi: 10.1089/jpm.2022.0386. PMID: 36194053
Systematic review and narrative summary: Treatments for and risk factors associated with respiratory tract secretions (death rattle) in the dying adult.
Kolb H, Snowden A, Stevens E
J Adv Nurs 2018 Jul;74(7):1446-1462. Epub 2018 Apr 6 doi: 10.1111/jan.13557. PMID: 29495089
Death rattle: critical review and research agenda.
Mercadamte S
Support Care Cancer 2014 Feb;22(2):571-5. Epub 2013 Nov 20 doi: 10.1007/s00520-013-2047-5. PMID: 24253734
Prevalence, impact, and treatment of death rattle: a systematic review.
Lokker ME, van Zuylen L, van der Rijt CC, van der Heide A
J Pain Symptom Manage 2014 Jan;47(1):105-22. Epub 2013 Jun 18 doi: 10.1016/j.jpainsymman.2013.03.011. PMID: 23790419
A systematic review of the prevalence of signs of impending death and symptoms in the last 2 weeks of life.
Kehl KA, Kowalkowski JA
Am J Hosp Palliat Care 2013 Sep;30(6):601-16. Epub 2012 Dec 12 doi: 10.1177/1049909112468222. PMID: 23236090

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