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Immune Hemolytic Anemia

MedGen UID:
452755
•Concept ID:
C0852336
•
Disease or Syndrome

Definition

An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs. [from NCI]

Professional guidelines

PubMed

Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.
Loriamini M, Cserti-Gazdewich C, Branch DR
Int J Mol Sci 2024 Apr 12;25(8) doi: 10.3390/ijms25084296. PMID: 38673882Free PMC Article
Primary and Secondary Immune Cytopenias: Evaluation and Treatment Approach in Children.
Kim TO, Despotovic JM
Hematol Oncol Clin North Am 2019 Jun;33(3):489-506. Epub 2019 Mar 23 doi: 10.1016/j.hoc.2019.01.005. PMID: 31030815
Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan.
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M; For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants
Int J Hematol 2017 Jul;106(1):3-15. Epub 2017 May 26 doi: 10.1007/s12185-017-2264-7. PMID: 28550351

Recent clinical studies

Etiology

A randomized and double-blind controlled trial evaluating the safety and efficacy of rituximab for warm auto-immune hemolytic anemia in adults (the RAIHA study).
Michel M, Terriou L, Roudot-Thoraval F, Hamidou M, Ebbo M, Le Guenno G, Galicier L, Audia S, Royer B, Morin AS, Marie Michot J, Jaccard A, Frenzel L, Khellaf M, Godeau B
Am J Hematol 2017 Jan;92(1):23-27. Epub 2016 Nov 10 doi: 10.1002/ajh.24570. PMID: 27696475
Ceftriaxone-induced immune hemolytic anemia.
Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S
Ann Pharmacother 2014 Dec;48(12):1594-604. Epub 2014 Aug 27 doi: 10.1177/1060028014548310. PMID: 25163809
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184
Autoimmune hemolytic anemia.
Agarwal B
Indian J Pediatr 1998 Sep-Oct;65(5):663-8. doi: 10.1007/BF02731038. PMID: 10773921
Auto-immune hemolytic anemia.
Issitt PD
Am J Med Technol 1974 Nov;40(11):479-95. PMID: 4215323

Diagnosis

DAT-Negative Autoimmune Hemolytic Anemia.
Rodberg K
Hematol Oncol Clin North Am 2022 Apr;36(2):307-313. Epub 2022 Mar 10 doi: 10.1016/j.hoc.2021.11.004. PMID: 35282952
A randomized and double-blind controlled trial evaluating the safety and efficacy of rituximab for warm auto-immune hemolytic anemia in adults (the RAIHA study).
Michel M, Terriou L, Roudot-Thoraval F, Hamidou M, Ebbo M, Le Guenno G, Galicier L, Audia S, Royer B, Morin AS, Marie Michot J, Jaccard A, Frenzel L, Khellaf M, Godeau B
Am J Hematol 2017 Jan;92(1):23-27. Epub 2016 Nov 10 doi: 10.1002/ajh.24570. PMID: 27696475
Non-immune Hemolysis: Diagnostic Considerations.
Beris P, Picard V
Semin Hematol 2015 Oct;52(4):287-303. Epub 2015 Jul 21 doi: 10.1053/j.seminhematol.2015.07.005. PMID: 26404441
Hereditary spherocytosis.
Iolascon A, Avvisati RA, Piscopo C
Transfus Clin Biol 2010 Sep;17(3):138-42. Epub 2010 Jul 23 doi: 10.1016/j.tracli.2010.05.006. PMID: 20655264
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184

Therapy

A randomized and double-blind controlled trial evaluating the safety and efficacy of rituximab for warm auto-immune hemolytic anemia in adults (the RAIHA study).
Michel M, Terriou L, Roudot-Thoraval F, Hamidou M, Ebbo M, Le Guenno G, Galicier L, Audia S, Royer B, Morin AS, Marie Michot J, Jaccard A, Frenzel L, Khellaf M, Godeau B
Am J Hematol 2017 Jan;92(1):23-27. Epub 2016 Nov 10 doi: 10.1002/ajh.24570. PMID: 27696475
How we investigate drug-induced immune hemolytic anemia.
Leger RM, Arndt PA, Garratty G
Immunohematology 2014;30(2):85-94. PMID: 25247618
Ceftriaxone-induced hemolysis.
Guleria VS, Sharma N, Amitabh S, Nair V
Indian J Pharmacol 2013 Sep-Oct;45(5):530-1. doi: 10.4103/0253-7613.117758. PMID: 24130395Free PMC Article
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184
Drug-induced immune hemolytic anemia.
Salama A
Expert Opin Drug Saf 2009 Jan;8(1):73-9. doi: 10.1517/14740330802577351. PMID: 19236219

Prognosis

Ceftriaxone-induced immune hemolytic anemia.
Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S
Ann Pharmacother 2014 Dec;48(12):1594-604. Epub 2014 Aug 27 doi: 10.1177/1060028014548310. PMID: 25163809
Laboratory tests for paroxysmal nocturnal hemoglobinuria.
Preis M, Lowrey CH
Am J Hematol 2014 Mar;89(3):339-41. doi: 10.1002/ajh.23612. PMID: 24127129
Autoimmune hemolytic anemia.
Gupta V, Shukla J, Bhatia BD
Indian J Pediatr 2008 May;75(5):451-4. Epub 2008 Jun 8 doi: 10.1007/s12098-008-0071-0. PMID: 18537006
Immune Hemolytic anemia.
Axelson JA, LoBuglio AF
Med Clin North Am 1980 Jul;64(4):597-606. doi: 10.1016/s0025-7125(16)31583-8. PMID: 6995725
Coombs--negative immune hemolytic anemia.
Gilliland BC
Semin Hematol 1976 Oct;13(4):267-75. PMID: 1006330

Clinical prediction guides

The magnitude and associated factors of immune hemolytic anemia among human immuno deficiency virus infected adults attending University of Gondar comprehensive specialized hospital north west Ethiopia 2021 GC, cross sectional study design.
Kebede SS, Yalew A, Yesuf T, Melku M, Bambo GM, Woldu B
PLoS One 2022;17(10):e0274464. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0274464. PMID: 36201533Free PMC Article
How we investigate drug-induced immune hemolytic anemia.
Leger RM, Arndt PA, Garratty G
Immunohematology 2014;30(2):85-94. PMID: 25247618
Ceftriaxone-induced immune hemolytic anemia.
Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S
Ann Pharmacother 2014 Dec;48(12):1594-604. Epub 2014 Aug 27 doi: 10.1177/1060028014548310. PMID: 25163809
Immune hemolytic anemia--selected topics.
Hoffman PC
Hematology Am Soc Hematol Educ Program 2009:80-6. doi: 10.1182/asheducation-2009.1.80. PMID: 20008185
Immune hemolytic anemia--selected topics.
Hoffman PC
Hematology Am Soc Hematol Educ Program 2006:13-8. doi: 10.1182/asheducation-2006.1.13. PMID: 17124033

Recent systematic reviews

Bendamustine-induced immune hemolytic anemia: a case report and systematic review of the literature.
Chan M, Silverstein WK, Nikonova A, Pavenski K, Hicks LK
Blood Adv 2020 Apr 28;4(8):1756-1759. doi: 10.1182/bloodadvances.2020001726. PMID: 32343794Free PMC Article

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