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Delirium Due to a General Medical Condition

MedGen UID:
452767
•Concept ID:
C0860621
•
Mental or Behavioral Dysfunction

Definition

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of a general medical condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelirium Due to a General Medical Condition

Professional guidelines

PubMed

Hypoactive Delirium: Differential Diagnosis, Evaluation, and Treatment.
Rosen JH, Bieber E, Matta SE, Sayde GE, Fedotova NO, deVries J, Rafferty M, Stern TA
Prim Care Companion CNS Disord 2024 Feb 8;26(1) doi: 10.4088/PCC.23f03602. PMID: 38334398
Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.
Latronico N, Rasulo FA, Eikermann M, Piva S
Crit Care 2023 Nov 13;27(1):439. doi: 10.1186/s13054-023-04676-3. PMID: 37957759Free PMC Article
Post-traumatic Confusional State: A Case Definition and Diagnostic Criteria.
Sherer M, Katz DI, Bodien YG, Arciniegas DB, Block C, Blum S, Doiron M, Frey K, Giacino JT, Graf MJP, Greenwald B, Hammond FM, Kalmar K, Kean J, Kraus MF, Nakase-Richardson R, Pavawalla S, Rosenbaum A, Stuss DT, Yablon SA
Arch Phys Med Rehabil 2020 Nov;101(11):2041-2050. Epub 2020 Jul 29 doi: 10.1016/j.apmr.2020.06.021. PMID: 32738198

Recent clinical studies

Etiology

The inter-relationship between delirium and dementia: the importance of delirium prevention.
Fong TG, Inouye SK
Nat Rev Neurol 2022 Oct;18(10):579-596. Epub 2022 Aug 26 doi: 10.1038/s41582-022-00698-7. PMID: 36028563Free PMC Article
The Effect of a Quality Improvement Intervention on Sleep and Delirium in Critically Ill Patients in a Surgical ICU.
Tonna JE, Dalton A, Presson AP, Zhang C, Colantuoni E, Lander K, Howard S, Beynon J, Kamdar BB
Chest 2021 Sep;160(3):899-908. Epub 2021 Mar 24 doi: 10.1016/j.chest.2021.03.030. PMID: 33773988Free PMC Article
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG; Nomenclature Consensus Working Group
Br J Anaesth 2018 Nov;121(5):1005-1012. Epub 2018 Jun 15 doi: 10.1016/j.bja.2017.11.087. PMID: 30336844Free PMC Article
Alcohol withdrawal syndrome: diagnostic and therapeutic methods.
Attilia F, Perciballi R, Rotondo C, Capriglione I, Iannuzzi S, Attilia ML, Coriale G, Vitali M, Cereatti F, Fiore M, Ceccanti M; Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip
Riv Psichiatr 2018 May-Jun;53(3):118-122. doi: 10.1708/2925.29413. PMID: 29912213
Delirium in Hospitalized Older Adults.
Marcantonio ER
N Engl J Med 2017 Oct 12;377(15):1456-1466. doi: 10.1056/NEJMcp1605501. PMID: 29020579Free PMC Article

Diagnosis

Malignant Catatonia: A Review for the Intensivist.
Connell J, Oldham M, Pandharipande P, Dittus RS, Wilson A, Mart M, Heckers S, Ely EW, Wilson JE
J Intensive Care Med 2023 Feb;38(2):137-150. Epub 2022 Jul 21 doi: 10.1177/08850666221114303. PMID: 35861966
Delirium.
Wilson JE, Mart MF, Cunningham C, Shehabi Y, Girard TD, MacLullich AMJ, Slooter AJC, Ely EW
Nat Rev Dis Primers 2020 Nov 12;6(1):90. doi: 10.1038/s41572-020-00223-4. PMID: 33184265Free PMC Article
Analgesia and sedation in patients with ARDS.
Chanques G, Constantin JM, Devlin JW, Ely EW, Fraser GL, Gélinas C, Girard TD, Guérin C, Jabaudon M, Jaber S, Mehta S, Langer T, Murray MJ, Pandharipande P, Patel B, Payen JF, Puntillo K, Rochwerg B, Shehabi Y, Strøm T, Olsen HT, Kress JP
Intensive Care Med 2020 Dec;46(12):2342-2356. Epub 2020 Nov 10 doi: 10.1007/s00134-020-06307-9. PMID: 33170331Free PMC Article
Psychosis.
Schrimpf LA, Aggarwal A, Lauriello J
Continuum (Minneap Minn) 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):845-860. doi: 10.1212/CON.0000000000000602. PMID: 29851881
Delirium in Hospitalized Older Adults.
Marcantonio ER
N Engl J Med 2017 Oct 12;377(15):1456-1466. doi: 10.1056/NEJMcp1605501. PMID: 29020579Free PMC Article

Therapy

The Effect of a Quality Improvement Intervention on Sleep and Delirium in Critically Ill Patients in a Surgical ICU.
Tonna JE, Dalton A, Presson AP, Zhang C, Colantuoni E, Lander K, Howard S, Beynon J, Kamdar BB
Chest 2021 Sep;160(3):899-908. Epub 2021 Mar 24 doi: 10.1016/j.chest.2021.03.030. PMID: 33773988Free PMC Article
Analgesia and sedation in patients with ARDS.
Chanques G, Constantin JM, Devlin JW, Ely EW, Fraser GL, Gélinas C, Girard TD, Guérin C, Jabaudon M, Jaber S, Mehta S, Langer T, Murray MJ, Pandharipande P, Patel B, Payen JF, Puntillo K, Rochwerg B, Shehabi Y, Strøm T, Olsen HT, Kress JP
Intensive Care Med 2020 Dec;46(12):2342-2356. Epub 2020 Nov 10 doi: 10.1007/s00134-020-06307-9. PMID: 33170331Free PMC Article
Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions.
Urits I, Peck J, Giacomazzi S, Patel R, Wolf J, Mathew D, Schwartz R, Kassem H, Urman RD, Kaye AD, Viswanath O
Adv Ther 2020 May;37(5):1897-1909. Epub 2020 Apr 9 doi: 10.1007/s12325-020-01317-x. PMID: 32274749
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG; Nomenclature Consensus Working Group
Br J Anaesth 2018 Nov;121(5):1005-1012. Epub 2018 Jun 15 doi: 10.1016/j.bja.2017.11.087. PMID: 30336844Free PMC Article
Alcohol withdrawal syndrome: diagnostic and therapeutic methods.
Attilia F, Perciballi R, Rotondo C, Capriglione I, Iannuzzi S, Attilia ML, Coriale G, Vitali M, Cereatti F, Fiore M, Ceccanti M; Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip
Riv Psichiatr 2018 May-Jun;53(3):118-122. doi: 10.1708/2925.29413. PMID: 29912213

Prognosis

The inter-relationship between delirium and dementia: the importance of delirium prevention.
Fong TG, Inouye SK
Nat Rev Neurol 2022 Oct;18(10):579-596. Epub 2022 Aug 26 doi: 10.1038/s41582-022-00698-7. PMID: 36028563Free PMC Article
Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions.
Urits I, Peck J, Giacomazzi S, Patel R, Wolf J, Mathew D, Schwartz R, Kassem H, Urman RD, Kaye AD, Viswanath O
Adv Ther 2020 May;37(5):1897-1909. Epub 2020 Apr 9 doi: 10.1007/s12325-020-01317-x. PMID: 32274749
A Practical Guide to Geriatric Syndromes in Older Adults With Cancer: A Focus on Falls, Cognition, Polypharmacy, and Depression.
Magnuson A, Sattar S, Nightingale G, Saracino R, Skonecki E, Trevino KM
Am Soc Clin Oncol Educ Book 2019 Jan;39:e96-e109. Epub 2019 May 17 doi: 10.1200/EDBK_237641. PMID: 31099668
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG; Nomenclature Consensus Working Group
Br J Anaesth 2018 Nov;121(5):1005-1012. Epub 2018 Jun 15 doi: 10.1016/j.bja.2017.11.087. PMID: 30336844Free PMC Article
Delirium in Hospitalized Older Adults.
Marcantonio ER
N Engl J Med 2017 Oct 12;377(15):1456-1466. doi: 10.1056/NEJMcp1605501. PMID: 29020579Free PMC Article

Clinical prediction guides

Virtual reality exposure before elective day care surgery to reduce anxiety and pain in children: A randomised controlled trial.
Eijlers R, Dierckx B, Staals LM, Berghmans JM, van der Schroeff MP, Strabbing EM, Wijnen RMH, Hillegers MHJ, Legerstee JS, Utens EMWJ
Eur J Anaesthesiol 2019 Oct;36(10):728-737. doi: 10.1097/EJA.0000000000001059. PMID: 31356373Free PMC Article
A Practical Guide to Geriatric Syndromes in Older Adults With Cancer: A Focus on Falls, Cognition, Polypharmacy, and Depression.
Magnuson A, Sattar S, Nightingale G, Saracino R, Skonecki E, Trevino KM
Am Soc Clin Oncol Educ Book 2019 Jan;39:e96-e109. Epub 2019 May 17 doi: 10.1200/EDBK_237641. PMID: 31099668
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, Shelton CL, Alderson P, Smith AF
Cochrane Database Syst Rev 2018 Aug 21;8(8):CD012317. doi: 10.1002/14651858.CD012317.pub2. PMID: 30129968Free PMC Article
The Mental Status Examination.
Norris D, Clark MS, Shipley S
Am Fam Physician 2016 Oct 15;94(8):635-641. PMID: 27929229
Delayed sequence intubation: a prospective observational study.
Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS
Ann Emerg Med 2015 Apr;65(4):349-55. Epub 2014 Oct 23 doi: 10.1016/j.annemergmed.2014.09.025. PMID: 25447559

Recent systematic reviews

Diagnostic accuracy of the 4AT for delirium: A systematic review and meta-analysis.
Hou L, Zhang Q, Cao L, Chen M, Wang Q, Li Y, Li S, Ge L, Yang K
Asian J Psychiatr 2023 Feb;80:103374. Epub 2022 Dec 5 doi: 10.1016/j.ajp.2022.103374. PMID: 36584541
Postoperative delirium screening tools for post-anaesthetic adult patients in non-intensive care units: A systematic review and meta-analysis.
Kim S, Choi E, Jung Y, Jang I
J Clin Nurs 2023 May;32(9-10):1691-1704. Epub 2021 Dec 8 doi: 10.1111/jocn.16157. PMID: 34881476
Exercise for acutely hospitalised older medical patients.
Hartley P, Keating JL, Jeffs KJ, Raymond MJ, Smith TO
Cochrane Database Syst Rev 2022 Nov 10;11(11):CD005955. doi: 10.1002/14651858.CD005955.pub3. PMID: 36355032Free PMC Article
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, Shelton CL, Alderson P, Smith AF
Cochrane Database Syst Rev 2018 Aug 21;8(8):CD012317. doi: 10.1002/14651858.CD012317.pub2. PMID: 30129968Free PMC Article
Postanesthesia Care for the Elderly Patient.
García PS, Duggan EW, McCullough IL, Lee SC, Fishman D
Clin Ther 2015 Dec 1;37(12):2651-65. Epub 2015 Nov 17 doi: 10.1016/j.clinthera.2015.10.018. PMID: 26598176

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