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Periapical granuloma

MedGen UID:
45395
•Concept ID:
C0031029
•
Disease or Syndrome
Synonyms: Granuloma, Periapical; Granulomas, Periapical; Periapical Granuloma; Periapical Granulomas
SNOMED CT: Apical granuloma (81407003); Periapical granuloma (81407003)
 
Monarch Initiative: MONDO:0006897

Definition

Chronic nonsuppurative inflammation of periapical tissue resulting from irritation following pulp disease or endodontic treatment. [from MONDO]

Professional guidelines

PubMed

Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.
Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH
BMC Oral Health 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191Free PMC Article
Prevalence and treatment of retrograde peri-implantitis: a retrospective cohort study covering a 20-year period.
Di Murro B, Canullo L, Pompa G, Di Murro C, Papi P
Clin Oral Investig 2021 Jul;25(7):4553-4561. Epub 2021 Jan 14 doi: 10.1007/s00784-020-03769-5. PMID: 33443685Free PMC Article
Ultrasound imaging for the differential diagnosis of periapical lesions of endodontic origin in comparison with histopathology - a systematic review and meta-analysis.
Natanasabapathy V, Arul B, Mishra A, Varghese A, Padmanaban S, Elango S, Arockiam S
Int Endod J 2021 May;54(5):693-711. Epub 2021 Jan 17 doi: 10.1111/iej.13465. PMID: 33368404

Recent clinical studies

Etiology

Immunohistochemical evaluation of cyclooxygenase-2 and mast cell density in periapical lesions.
Malik S, Kamboj M, Narwal A, Devi A
Int Endod J 2023 Aug;56(8):980-990. Epub 2023 May 23 doi: 10.1111/iej.13931. PMID: 37171246
Association between the baseline gene expression profile in periapical granuloma and periapical wound healing after surgical endodontic treatment.
Ahmed MA, Nazim F, Ahmed K, Bari MF, Abdulwahed A, AlMokhatieb AA, Alalvi Y, Abduljabbar T, Mughal N, Abidi SH
Sci Rep 2022 Aug 15;12(1):13824. doi: 10.1038/s41598-022-17774-z. PMID: 35970906Free PMC Article
Expression of epithelial growth factors and of apoptosis-regulating proteins, and presence of CD57+ cells in the development of inflammatory periapical lesions.
Valente WAS, Barrocas D, Armada L, Pires FR
J Appl Oral Sci 2022;30:e20210413. Epub 2022 Feb 21 doi: 10.1590/1678-7757-2021-0413. PMID: 35195153Free PMC Article
Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.
Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH
BMC Oral Health 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191Free PMC Article
The Expression of Semaphorin 7A in Human Periapical Lesions.
Song Y, Wang L, Li J, Yang F, Gao Y, Song D, Sun J, Ye L, Zhang L, Huang D
J Endod 2021 Oct;47(10):1631-1639. Epub 2021 Jun 11 doi: 10.1016/j.joen.2021.06.005. PMID: 34126161

Diagnosis

Utility of Ultrasonography for Diagnosing and Differentiating Periapical Granuloma from Radicular Cyst.
Jia W, Jing H, Xia G, Angang D, Wei Z, Pengfei Z, Shujun R, Mengying M, Zhengwei H, Shensheng G
Acad Radiol 2023 Oct;30(10):2329-2339. Epub 2023 Jun 30 doi: 10.1016/j.acra.2023.05.039. PMID: 37394410
A deep learning approach for radiological detection and classification of radicular cysts and periapical granulomas.
Ver Berne J, Saadi SB, Politis C, Jacobs R
J Dent 2023 Aug;135:104581. Epub 2023 Jun 7 doi: 10.1016/j.jdent.2023.104581. PMID: 37295547
The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.
Rios Osorio N, Caviedes-Bucheli J, Mosquera-Guevara L, Adames-Martinez JS, Gomez-Pinto D, Jimenez-Jimenez K, Avendano Maz H, Bornacelly-Mendoza S
Eur Endod J 2023 Jan;8(1):20-36. doi: 10.14744/eej.2022.26918. PMID: 36748442Free PMC Article
Differential diagnosis and therapeutic approach to periapical cysts in daily dental practice.
Gallego Romero D, Torres Lagares D, GarcIa Calderón M, Romero Ruiz MM, Infante Cossio P, Gutiérrez Pérez JL
Med Oral 2002 Jan-Feb;7(1):54-8; 59-2. PMID: 11788809
Macrophages in periapical lesions.
Metzger Z
Endod Dent Traumatol 2000 Feb;16(1):1-8. doi: 10.1034/j.1600-9657.2000.016001001.x. PMID: 11202850

Therapy

Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.
Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH
BMC Oral Health 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191Free PMC Article
Ultrasound imaging for the differential diagnosis of periapical lesions of endodontic origin in comparison with histopathology - a systematic review and meta-analysis.
Natanasabapathy V, Arul B, Mishra A, Varghese A, Padmanaban S, Elango S, Arockiam S
Int Endod J 2021 May;54(5):693-711. Epub 2021 Jan 17 doi: 10.1111/iej.13465. PMID: 33368404
The post-endodontic periapical lesion: histologic and etiopathogenic aspects.
García CC, Sempere FV, Diago MP, Bowen EM
Med Oral Patol Oral Cir Bucal 2007 Dec 1;12(8):E585-90. PMID: 18059244
Periradicular curettage.
Lin LM, Gaengler P, Langeland K
Int Endod J 1996 Jul;29(4):220-7. doi: 10.1111/j.1365-2591.1996.tb01373.x. PMID: 9206437
Immunologic aspects of pulpal-periapical diseases. A review.
Morse DR
Oral Surg Oral Med Oral Pathol 1977 Mar;43(3):436-51. doi: 10.1016/0030-4220(77)90331-0. PMID: 320531

Prognosis

Association between the baseline gene expression profile in periapical granuloma and periapical wound healing after surgical endodontic treatment.
Ahmed MA, Nazim F, Ahmed K, Bari MF, Abdulwahed A, AlMokhatieb AA, Alalvi Y, Abduljabbar T, Mughal N, Abidi SH
Sci Rep 2022 Aug 15;12(1):13824. doi: 10.1038/s41598-022-17774-z. PMID: 35970906Free PMC Article
Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.
Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH
BMC Oral Health 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191Free PMC Article
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Altaie AM, Venkatachalam T, Samaranayake LP, Soliman SSM, Hamoudi R
Front Immunol 2021;12:707267. Epub 2021 Sep 3 doi: 10.3389/fimmu.2021.707267. PMID: 34539639Free PMC Article
Apical periodontitis: preliminary assessment of microbiota by 16S rRNA high throughput amplicon target sequencing.
Mussano F, Ferrocino I, Gavrilova N, Genova T, Dell'Acqua A, Cocolin L, Carossa S
BMC Oral Health 2018 Apr 2;18(1):55. doi: 10.1186/s12903-018-0520-8. PMID: 29609564Free PMC Article
Periapical granuloma associated with extracted teeth.
Omoregie FO, Ojo MA, Saheeb B, Odukoya O
Niger J Clin Pract 2011 Jul-Sep;14(3):293-6. doi: 10.4103/1119-3077.86770. PMID: 22037071

Clinical prediction guides

ALDH1 expression and potential clinical implications in chronic inflammatory periapical lesions.
Farias ZBBM, Silva LPD, de Arruda JAA, Cavalcante JS, Almeida HCR, Oliveira MCV, Souza LB, Sobral APV
Braz Oral Res 2022;36:e019. Epub 2022 Feb 9 doi: 10.1590/1807-3107bor-2022.vol36.0019. PMID: 35170687
Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.
Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH
BMC Oral Health 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191Free PMC Article
Macrophages subpopulations in chronic periapical lesions according to clinical and morphological aspects.
França GM, Carmo AFD, Costa Neto H, Andrade ALDL, Lima KC, Galvão HC
Braz Oral Res 2019 May 27;33:e047. doi: 10.1590/1807-3107bor-2019.vol33.0047. PMID: 31141038
Biofilms and apical periodontitis: study of prevalence and association with clinical and histopathologic findings.
Ricucci D, Siqueira JF Jr
J Endod 2010 Aug;36(8):1277-88. Epub 2010 Jun 14 doi: 10.1016/j.joen.2010.04.007. PMID: 20647081
Macrophages in periapical lesions.
Metzger Z
Endod Dent Traumatol 2000 Feb;16(1):1-8. doi: 10.1034/j.1600-9657.2000.016001001.x. PMID: 11202850

Recent systematic reviews

Prevalence of unculturable bacteria in the periapical abscess: A systematic review and meta-analysis.
Altaie AM, Saddik B, Alsaegh MA, Soliman SSM, Hamoudi R, Samaranayake LP
PLoS One 2021;16(8):e0255485. Epub 2021 Aug 5 doi: 10.1371/journal.pone.0255485. PMID: 34351963Free PMC Article
Ultrasound imaging for the differential diagnosis of periapical lesions of endodontic origin in comparison with histopathology - a systematic review and meta-analysis.
Natanasabapathy V, Arul B, Mishra A, Varghese A, Padmanaban S, Elango S, Arockiam S
Int Endod J 2021 May;54(5):693-711. Epub 2021 Jan 17 doi: 10.1111/iej.13465. PMID: 33368404
Accuracy of computer-assisted image analysis in the diagnosis of maxillofacial radiolucent lesions: A systematic review and meta-analysis.
Silva VKS, Vieira WA, Bernardino ÍM, Travençolo BAN, Bittencourt MAV, Blumenberg C, Paranhos LR, Galvão HC
Dentomaxillofac Radiol 2020 Mar;49(3):20190204. Epub 2019 Nov 20 doi: 10.1259/dmfr.20190204. PMID: 31709811Free PMC Article

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