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Pancreatic large cell neuroendocrine carcinoma

MedGen UID:
459465
Concept ID:
C2987239
Neoplastic Process
Synonyms: large cell neuroendocrine carcinoma of pancreas; pancreas large cell neuroendocrine carcinoma; Pancreatic Large Cell NEC; pancreatic large cell NEC; Pancreatic Large Cell NEC G3; pancreatic large cell NEC G3; Pancreatic Large Cell Neuroendocrine Carcinoma; pancreatic large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0006347

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic large cell neuroendocrine carcinoma

Professional guidelines

PubMed

Sugawara T, Rodriguez Franco S, Franklin O, Kirsch MJ, Colborn KL, Del Chiaro M, Schulick RD
J Am Coll Surg 2023 Sep 1;237(3):515-524. Epub 2023 May 5 doi: 10.1097/XCS.0000000000000735. PMID: 37146214

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Detjen K, Hammerich L, Özdirik B, Demir M, Wiedenmann B, Tacke F, Jann H, Roderburg C
Neuroendocrinology 2021;111(3):217-236. Epub 2020 Jul 2 doi: 10.1159/000509864. PMID: 32615560
Kawasaki K, Fujii M, Sato T
Dis Model Mech 2018 Feb 26;11(2) doi: 10.1242/dmm.029595. PMID: 29590641Free PMC Article
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552

Diagnosis

Dayton TL, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, Lap L, Dost AFM, Beumer J, Levy S, van Leeuwaarde RS, Hackeng WM, Samsom K, Voegele C, Sexton-Oates A, Begthel H, Korving J, Hillen L, Brosens LAA, Lantuejoul S, Jaksani S, Kok NFM, Hartemink KJ, Klomp HM, Borel Rinkes IHM, Dingemans AM, Valk GD, Vriens MR, Buikhuisen W, van den Berg J, Tesselaar M, Derks J, Speel EJ, Foll M, Fernández-Cuesta L, Clevers H
Cancer Cell 2023 Dec 11;41(12):2083-2099.e9. doi: 10.1016/j.ccell.2023.11.007. PMID: 38086335
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Bellizzi AM
Surg Oncol Clin N Am 2020 Apr;29(2):185-208. doi: 10.1016/j.soc.2019.11.003. PMID: 32151355Free PMC Article
Chittiboina P, Lonser RR
Handb Clin Neurol 2015;132:139-56. doi: 10.1016/B978-0-444-62702-5.00010-X. PMID: 26564077Free PMC Article
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552

Therapy

Dijkstra KK, van den Berg JG, Weeber F, van de Haar J, Velds A, Kaing S, Peters DDGC, Eskens FALM, de Groot DA, Tesselaar MET, Voest EE
Front Endocrinol (Lausanne) 2021;12:627819. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.627819. PMID: 33776923Free PMC Article
Pulvirenti A, Raj N, Cingarlini S, Pea A, Tang LH, Luchini C, Chou JF, Grego E, Marinova I, Capanu M, Landoni L, Scarpa A, Allen PJ, Klimstra DS, Reidy-Lagunes DL
Pancreas 2021 Feb 1;50(2):138-146. doi: 10.1097/MPA.0000000000001740. PMID: 33565789Free PMC Article
Detjen K, Hammerich L, Özdirik B, Demir M, Wiedenmann B, Tacke F, Jann H, Roderburg C
Neuroendocrinology 2021;111(3):217-236. Epub 2020 Jul 2 doi: 10.1159/000509864. PMID: 32615560
Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Rindi G, Wiedenmann B
Nat Rev Endocrinol 2011 Aug 2;8(1):54-64. doi: 10.1038/nrendo.2011.120. PMID: 21808296

Prognosis

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Detjen K, Hammerich L, Özdirik B, Demir M, Wiedenmann B, Tacke F, Jann H, Roderburg C
Neuroendocrinology 2021;111(3):217-236. Epub 2020 Jul 2 doi: 10.1159/000509864. PMID: 32615560
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552
Beggs RE, Kelly ME, Eltayeb O, Crotty P, McDermott R, Ridgway PF
JOP 2012 Sep 10;13(5):470-5. doi: 10.6092/1590-8577/821. PMID: 22964952

Clinical prediction guides

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Detjen K, Hammerich L, Özdirik B, Demir M, Wiedenmann B, Tacke F, Jann H, Roderburg C
Neuroendocrinology 2021;111(3):217-236. Epub 2020 Jul 2 doi: 10.1159/000509864. PMID: 32615560
Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609
Volante M, Gatti G, Papotti M
Endocrine 2015 Nov;50(2):315-9. Epub 2015 Mar 21 doi: 10.1007/s12020-015-0578-x. PMID: 25795289
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552

Recent systematic reviews

Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

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