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Flat affect

MedGen UID:
472962
•Concept ID:
C0233471
•
Finding
Synonym: Flat Affect
SNOMED CT: Flat affect (932006)

Definition

The absence of emotional expressiveness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlat affect

Professional guidelines

PubMed

Comparison of clinical characteristics and treatment efficacy in childhood-onset schizophrenia and adolescent-onset schizophrenia in mainland China: A retrospective study.
Cheng X, Zhang H, Zhang J, Xu P, Jin P, Fang H, Chu K, Ke X
Early Interv Psychiatry 2021 Dec;15(6):1721-1729. Epub 2021 Jan 19 doi: 10.1111/eip.13121. PMID: 33465837

Recent clinical studies

Etiology

Relative importance of speech and voice features in the classification of schizophrenia and depression.
Berardi M, Brosch K, Pfarr JK, Schneider K, Sültmann A, Thomas-Odenthal F, Wroblewski A, Usemann P, Philipsen A, Dannlowski U, Nenadić I, Kircher T, Krug A, Stein F, Dietrich M
Transl Psychiatry 2023 Sep 19;13(1):298. doi: 10.1038/s41398-023-02594-0. PMID: 37726285Free PMC Article
Current Concepts and Treatments of Schizophrenia.
Stępnicki P, Kondej M, Kaczor AA
Molecules 2018 Aug 20;23(8) doi: 10.3390/molecules23082087. PMID: 30127324Free PMC Article
Vitamin D in schizophrenia: a clinical review.
Chiang M, Natarajan R, Fan X
Evid Based Ment Health 2016 Feb;19(1):6-9. Epub 2016 Jan 14 doi: 10.1136/eb-2015-102117. PMID: 26767392Free PMC Article
Emotional face processing and flat affect in schizophrenia: functional and structural neural correlates.
Lepage M, Sergerie K, Benoit A, Czechowska Y, Dickie E, Armony JL
Psychol Med 2011 Sep;41(9):1833-44. Epub 2011 Feb 2 doi: 10.1017/S0033291711000031. PMID: 21284912
The importance of diagnosing and managing ICU delirium.
Pun BT, Ely EW
Chest 2007 Aug;132(2):624-36. doi: 10.1378/chest.06-1795. PMID: 17699134

Diagnosis

Relative importance of speech and voice features in the classification of schizophrenia and depression.
Berardi M, Brosch K, Pfarr JK, Schneider K, Sültmann A, Thomas-Odenthal F, Wroblewski A, Usemann P, Philipsen A, Dannlowski U, Nenadić I, Kircher T, Krug A, Stein F, Dietrich M
Transl Psychiatry 2023 Sep 19;13(1):298. doi: 10.1038/s41398-023-02594-0. PMID: 37726285Free PMC Article
Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis.
Bridgwater M, Bachman P, Tervo-Clemmens B, Haas G, Hayes R, Luna B, Salisbury DF, Jalbrzikowski M
Psychol Med 2022 Jul;52(9):1698-1709. Epub 2020 Oct 6 doi: 10.1017/S0033291720003463. PMID: 33019960Free PMC Article
The importance of diagnosing and managing ICU delirium.
Pun BT, Ely EW
Chest 2007 Aug;132(2):624-36. doi: 10.1378/chest.06-1795. PMID: 17699134
Prosody and lexical accuracy in flat affect schizophrenia.
Alpert M, Rosenberg SD, Pouget ER, Shaw RJ
Psychiatry Res 2000 Dec 27;97(2-3):107-18. doi: 10.1016/s0165-1781(00)00231-6. PMID: 11166083
Construct validity of negative symptoms: an empirical and conceptual review.
Earnst KS, Kring AM
Clin Psychol Rev 1997;17(2):167-89. doi: 10.1016/s0272-7358(96)00052-9. PMID: 9140714

Therapy

Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis.
Bridgwater M, Bachman P, Tervo-Clemmens B, Haas G, Hayes R, Luna B, Salisbury DF, Jalbrzikowski M
Psychol Med 2022 Jul;52(9):1698-1709. Epub 2020 Oct 6 doi: 10.1017/S0033291720003463. PMID: 33019960Free PMC Article
Current Concepts and Treatments of Schizophrenia.
Stępnicki P, Kondej M, Kaczor AA
Molecules 2018 Aug 20;23(8) doi: 10.3390/molecules23082087. PMID: 30127324Free PMC Article
Emotional face processing and flat affect in schizophrenia: functional and structural neural correlates.
Lepage M, Sergerie K, Benoit A, Czechowska Y, Dickie E, Armony JL
Psychol Med 2011 Sep;41(9):1833-44. Epub 2011 Feb 2 doi: 10.1017/S0033291711000031. PMID: 21284912
The importance of diagnosing and managing ICU delirium.
Pun BT, Ely EW
Chest 2007 Aug;132(2):624-36. doi: 10.1378/chest.06-1795. PMID: 17699134
The hypoandrogenic woman: pathophysiologic overview.
Bachmann GA
Fertil Steril 2002 Apr;77 Suppl 4:S72-6. doi: 10.1016/s0015-0282(02)03003-0. PMID: 12007907

Prognosis

Comparison of clinical characteristics and treatment efficacy in childhood-onset schizophrenia and adolescent-onset schizophrenia in mainland China: A retrospective study.
Cheng X, Zhang H, Zhang J, Xu P, Jin P, Fang H, Chu K, Ke X
Early Interv Psychiatry 2021 Dec;15(6):1721-1729. Epub 2021 Jan 19 doi: 10.1111/eip.13121. PMID: 33465837
Episodic memory bias and the symptoms of schizophrenia.
Lepage M, Sergerie K, Pelletier M, Harvey PO
Can J Psychiatry 2007 Nov;52(11):702-9. doi: 10.1177/070674370705201104. PMID: 18399037
The importance of diagnosing and managing ICU delirium.
Pun BT, Ely EW
Chest 2007 Aug;132(2):624-36. doi: 10.1378/chest.06-1795. PMID: 17699134
Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures.
Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC
Schizophr Bull 2006 Apr;32(2):279-87. Epub 2006 Feb 1 doi: 10.1093/schbul/sbj041. PMID: 16452608Free PMC Article
Construct validity of negative symptoms: an empirical and conceptual review.
Earnst KS, Kring AM
Clin Psychol Rev 1997;17(2):167-89. doi: 10.1016/s0272-7358(96)00052-9. PMID: 9140714

Clinical prediction guides

Relative importance of speech and voice features in the classification of schizophrenia and depression.
Berardi M, Brosch K, Pfarr JK, Schneider K, Sültmann A, Thomas-Odenthal F, Wroblewski A, Usemann P, Philipsen A, Dannlowski U, Nenadić I, Kircher T, Krug A, Stein F, Dietrich M
Transl Psychiatry 2023 Sep 19;13(1):298. doi: 10.1038/s41398-023-02594-0. PMID: 37726285Free PMC Article
Comparison of clinical characteristics and treatment efficacy in childhood-onset schizophrenia and adolescent-onset schizophrenia in mainland China: A retrospective study.
Cheng X, Zhang H, Zhang J, Xu P, Jin P, Fang H, Chu K, Ke X
Early Interv Psychiatry 2021 Dec;15(6):1721-1729. Epub 2021 Jan 19 doi: 10.1111/eip.13121. PMID: 33465837
Emotional face processing and flat affect in schizophrenia: functional and structural neural correlates.
Lepage M, Sergerie K, Benoit A, Czechowska Y, Dickie E, Armony JL
Psychol Med 2011 Sep;41(9):1833-44. Epub 2011 Feb 2 doi: 10.1017/S0033291711000031. PMID: 21284912
Episodic memory bias and the symptoms of schizophrenia.
Lepage M, Sergerie K, Pelletier M, Harvey PO
Can J Psychiatry 2007 Nov;52(11):702-9. doi: 10.1177/070674370705201104. PMID: 18399037
The importance of diagnosing and managing ICU delirium.
Pun BT, Ely EW
Chest 2007 Aug;132(2):624-36. doi: 10.1378/chest.06-1795. PMID: 17699134

Recent systematic reviews

Voice patterns in schizophrenia: A systematic review and Bayesian meta-analysis.
Parola A, Simonsen A, Bliksted V, Fusaroli R
Schizophr Res 2020 Feb;216:24-40. Epub 2019 Dec 13 doi: 10.1016/j.schres.2019.11.031. PMID: 31839552

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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