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Gastric Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
474044
•Concept ID:
C3272411
•
Neoplastic Process
Synonym: Gastric MANEC

Definition

A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: A nationwide cohort study.
van der Veen A, Seesing MFJ, Wijnhoven BPL, de Steur WO, van Berge Henegouwen MI, Rosman C, van Sandick JW, Mook S, Haj Mohammad N, Ruurda JP, Brosens LAA, van Hillegersberg R; (MA)NEC group
Eur J Surg Oncol 2018 Dec;44(12):1955-1962. Epub 2018 Aug 2 doi: 10.1016/j.ejso.2018.07.058. PMID: 30201419

Recent clinical studies

Etiology

Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma.
Lin J, Zhao Y, Zhou Y, Tian Y, He Q, Lin J, Hao H, Zou B, Jiang L, Zhao G, Lin W, Xu Y, Li Z, Xue F, Li S, Fu W, Li Y, Xu Z, Li Y, Chen J, Zhou X, Zhu Z, Cai L, Li E, Li H, Zheng C, Li P, Huang C, Xie J
JAMA Netw Open 2021 Jul 1;4(7):e2114180. doi: 10.1001/jamanetworkopen.2021.14180. PMID: 34313744Free PMC Article
Comprehensive genetic features of gastric mixed adenoneuroendocrine carcinomas and pure neuroendocrine carcinomas.
Koh J, Nam SK, Kwak Y, Kim G, Kim KK, Lee BC, Ahn SH, Park DJ, Kim HH, Park KU, Kim WH, Lee HS
J Pathol 2021 Jan;253(1):94-105. Epub 2020 Oct 22 doi: 10.1002/path.5556. PMID: 32985687
Effect of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: results from a large, two-institution series.
Wang JB, Xue Z, Lu J, He QL, Zheng ZF, Xu BB, Xie JW, Li P, Xu Y, Lin JX, Chen QY, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Huang CM, Zheng CH
BMC Cancer 2020 Oct 15;20(1):1002. doi: 10.1186/s12885-020-07506-9. PMID: 33059606Free PMC Article
Prognostic factors for survival after curative resection of gastric mixed adenoneuroendocrine carcinoma: a series of 80 patients.
Xie JW, Lu J, Wang JB, Lin JX, Chen QY, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Zheng CH, Li P, Huang CM
BMC Cancer 2018 Oct 22;18(1):1021. doi: 10.1186/s12885-018-4943-z. PMID: 30348122Free PMC Article
Gastric mixed adenoneuroendocrine carcinoma: correlation of histologic characteristics with prognosis.
Nie L, Li M, He X, Feng A, Wu H, Fan X
Ann Diagn Pathol 2016 Dec;25:48-53. Epub 2016 Sep 17 doi: 10.1016/j.anndiagpath.2016.09.004. PMID: 27806846

Diagnosis

Endoscopic findings of gastric mixed adenoneuroendocrine carcinoma: A case report.
Takahashi K, Fujiya M, Sasaki T, Sugiyama Y, Murakami Y, Iwama T, Kunogi T, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Yuzawa S, Takei H, Okumura T
Medicine (Baltimore) 2020 Sep 18;99(38):e22306. doi: 10.1097/MD.0000000000022306. PMID: 32957392Free PMC Article
Efficacy of XELOX adjuvant chemotherapy for gastric mixed adenoneuroendocrine carcinoma: A case report.
Lin Z, Chen J, Guo Y
Medicine (Baltimore) 2019 Jun;98(23):e16000. doi: 10.1097/MD.0000000000016000. PMID: 31169743Free PMC Article
Gastric mixed adenoneuroendocrine carcinoma: correlation of histologic characteristics with prognosis.
Nie L, Li M, He X, Feng A, Wu H, Fan X
Ann Diagn Pathol 2016 Dec;25:48-53. Epub 2016 Sep 17 doi: 10.1016/j.anndiagpath.2016.09.004. PMID: 27806846
Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component.
Yamaguchi E, Sato Y, Oe T, Nishi T, Koike M, Kitakado Y, Takubo K
Clin J Gastroenterol 2015 Apr;8(2):82-7. Epub 2015 Apr 1 doi: 10.1007/s12328-015-0562-2. PMID: 25823931
Gastric mixed adenoneuroendocrine carcinoma with a good prognosis.
Fukuba N, Yuki T, Ishihara S, Sonoyama H, Tada Y, Kusunoki R, Oka A, Oshima N, Moriyama I, Kawashima K, Kinoshita Y
Intern Med 2014;53(22):2585-8. Epub 2014 Nov 15 doi: 10.2169/internalmedicine.53.3328. PMID: 25400179

Therapy

Effect of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: results from a large, two-institution series.
Wang JB, Xue Z, Lu J, He QL, Zheng ZF, Xu BB, Xie JW, Li P, Xu Y, Lin JX, Chen QY, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Huang CM, Zheng CH
BMC Cancer 2020 Oct 15;20(1):1002. doi: 10.1186/s12885-020-07506-9. PMID: 33059606Free PMC Article
Efficacy of XELOX adjuvant chemotherapy for gastric mixed adenoneuroendocrine carcinoma: A case report.
Lin Z, Chen J, Guo Y
Medicine (Baltimore) 2019 Jun;98(23):e16000. doi: 10.1097/MD.0000000000016000. PMID: 31169743Free PMC Article

Prognosis

Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma.
Lin J, Zhao Y, Zhou Y, Tian Y, He Q, Lin J, Hao H, Zou B, Jiang L, Zhao G, Lin W, Xu Y, Li Z, Xue F, Li S, Fu W, Li Y, Xu Z, Li Y, Chen J, Zhou X, Zhu Z, Cai L, Li E, Li H, Zheng C, Li P, Huang C, Xie J
JAMA Netw Open 2021 Jul 1;4(7):e2114180. doi: 10.1001/jamanetworkopen.2021.14180. PMID: 34313744Free PMC Article
Endoscopic findings of gastric mixed adenoneuroendocrine carcinoma: A case report.
Takahashi K, Fujiya M, Sasaki T, Sugiyama Y, Murakami Y, Iwama T, Kunogi T, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Yuzawa S, Takei H, Okumura T
Medicine (Baltimore) 2020 Sep 18;99(38):e22306. doi: 10.1097/MD.0000000000022306. PMID: 32957392Free PMC Article
Gastric mixed adenoneuroendocrine carcinoma: correlation of histologic characteristics with prognosis.
Nie L, Li M, He X, Feng A, Wu H, Fan X
Ann Diagn Pathol 2016 Dec;25:48-53. Epub 2016 Sep 17 doi: 10.1016/j.anndiagpath.2016.09.004. PMID: 27806846
Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component.
Yamaguchi E, Sato Y, Oe T, Nishi T, Koike M, Kitakado Y, Takubo K
Clin J Gastroenterol 2015 Apr;8(2):82-7. Epub 2015 Apr 1 doi: 10.1007/s12328-015-0562-2. PMID: 25823931
Gastric mixed adenoneuroendocrine carcinoma with a good prognosis.
Fukuba N, Yuki T, Ishihara S, Sonoyama H, Tada Y, Kusunoki R, Oka A, Oshima N, Moriyama I, Kawashima K, Kinoshita Y
Intern Med 2014;53(22):2585-8. Epub 2014 Nov 15 doi: 10.2169/internalmedicine.53.3328. PMID: 25400179

Clinical prediction guides

Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma.
Lin J, Zhao Y, Zhou Y, Tian Y, He Q, Lin J, Hao H, Zou B, Jiang L, Zhao G, Lin W, Xu Y, Li Z, Xue F, Li S, Fu W, Li Y, Xu Z, Li Y, Chen J, Zhou X, Zhu Z, Cai L, Li E, Li H, Zheng C, Li P, Huang C, Xie J
JAMA Netw Open 2021 Jul 1;4(7):e2114180. doi: 10.1001/jamanetworkopen.2021.14180. PMID: 34313744Free PMC Article
Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component.
Yamaguchi E, Sato Y, Oe T, Nishi T, Koike M, Kitakado Y, Takubo K
Clin J Gastroenterol 2015 Apr;8(2):82-7. Epub 2015 Apr 1 doi: 10.1007/s12328-015-0562-2. PMID: 25823931
Neuroendocrine liver metastasis in gastric mixed adenoneuroendocrine carcinoma with trilineage cell differentiation: a case report.
Zhang W, Xiao W, Ma H, Sun M, Chen H, Zheng S
Int J Clin Exp Pathol 2014;7(9):6333-8. Epub 2014 Aug 15 PMID: 25337287Free PMC Article

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