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Hepatocellular Small Cell Change

MedGen UID:
474647
•Concept ID:
C3273014
•
Finding
Synonym: Small Cell Dysplasia

Definition

A premalignant neoplastic lesion of the liver. It is characterized by the presence of hepatocytes with decreased cell volume, increased nuclear/cytoplasmic ratio, basophilia, mild nuclear pleomorphism, and hyperchromasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatocellular Small Cell Change

Professional guidelines

PubMed

Immune checkpoint inhibition for the treatment of cancers: An update and critical review of ongoing clinical trials.
Akhbariyoon H, Azizpour Y, Esfahani MF, Firoozabad MSM, Rad MR, Esfahani KS, Khoshavi N, Karimi N, Shirinisaz A, Abedi F, Rad MR, Sharifi P
Clin Immunol 2021 Nov;232:108873. Epub 2021 Oct 21 doi: 10.1016/j.clim.2021.108873. PMID: 34688855
ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment.
Khwairakpam AD, Shyamananda MS, Sailo BL, Rathnakaram SR, Padmavathi G, Kotoky J, Kunnumakkara AB
Curr Drug Targets 2015;16(2):156-63. doi: 10.2174/1389450115666141224125117. PMID: 25537655
Monitoring treatment response with color and power Doppler.
Lagalla R, Caruso G, Finazzo M
Eur J Radiol 1998 May;27 Suppl 2:S149-56. doi: 10.1016/s0720-048x(98)00056-4. PMID: 9652515

Recent clinical studies

Etiology

Stromal morphological changes and immunophenotypic features of precancerous lesions and hepatocellular carcinoma.
Chen D, Li Z, Zhu W, Cheng Q, Song Q, Qian L, Zhu JY
J Clin Pathol 2019 Apr;72(4):295-303. Epub 2019 Jan 4 doi: 10.1136/jclinpath-2018-205611. PMID: 30610005
Latest developments in precancerous lesions of hepatocellular carcinoma.
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Alcohol and cancer.
Pöschl G, Seitz HK
Alcohol Alcohol 2004 May-Jun;39(3):155-65. doi: 10.1093/alcalc/agh057. PMID: 15082451
Alcohol and cancer.
Seitz HK, Pöschl G, Simanowski UA
Recent Dev Alcohol 1998;14:67-95. doi: 10.1007/0-306-47148-5_4. PMID: 9751943

Diagnosis

MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives.
Hochreuter MY, Dall M, Treebak JT, Barrès R
Mol Metab 2022 Nov;65:101581. Epub 2022 Aug 23 doi: 10.1016/j.molmet.2022.101581. PMID: 36028120Free PMC Article
Current understanding of primary biliary cholangitis.
Tanaka A
Clin Mol Hepatol 2021 Jan;27(1):1-21. Epub 2020 Dec 3 doi: 10.3350/cmh.2020.0028. PMID: 33264835Free PMC Article
Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features.
Choi WT, Kakar S
Adv Anat Pathol 2018 Jul;25(4):254-262. doi: 10.1097/PAP.0000000000000189. PMID: 29649004
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Histopathology of liver cancers.
Kojiro M
Best Pract Res Clin Gastroenterol 2005 Feb;19(1):39-62. doi: 10.1016/j.bpg.2004.10.007. PMID: 15757804

Therapy

Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
MicroRNA-mediated interactions between host and hepatitis C virus.
Li H, Jiang JD, Peng ZG
World J Gastroenterol 2016 Jan 28;22(4):1487-96. doi: 10.3748/wjg.v22.i4.1487. PMID: 26819516Free PMC Article
Targeting tyrosine kinase receptors in hepatocellular carcinoma.
Muntané J, De la Rosa AJ, Docobo F, García-Carbonero R, Padillo FJ
Curr Cancer Drug Targets 2013 Mar;13(3):300-12. doi: 10.2174/15680096113139990075. PMID: 23016985
Alcohol and cancer.
Pöschl G, Seitz HK
Alcohol Alcohol 2004 May-Jun;39(3):155-65. doi: 10.1093/alcalc/agh057. PMID: 15082451
Alcohol and cancer.
Seitz HK, Pöschl G, Simanowski UA
Recent Dev Alcohol 1998;14:67-95. doi: 10.1007/0-306-47148-5_4. PMID: 9751943

Prognosis

A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.
Shi F, Wu Y, Wang K, Wang J, Liu M, Sun X
J Cell Mol Med 2023 Nov;27(21):3296-3312. Epub 2023 Aug 8 doi: 10.1111/jcmm.17900. PMID: 37551845Free PMC Article
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives.
Hochreuter MY, Dall M, Treebak JT, Barrès R
Mol Metab 2022 Nov;65:101581. Epub 2022 Aug 23 doi: 10.1016/j.molmet.2022.101581. PMID: 36028120Free PMC Article
Current understanding of primary biliary cholangitis.
Tanaka A
Clin Mol Hepatol 2021 Jan;27(1):1-21. Epub 2020 Dec 3 doi: 10.3350/cmh.2020.0028. PMID: 33264835Free PMC Article
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Clinical prediction guides

A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.
Shi F, Wu Y, Wang K, Wang J, Liu M, Sun X
J Cell Mol Med 2023 Nov;27(21):3296-3312. Epub 2023 Aug 8 doi: 10.1111/jcmm.17900. PMID: 37551845Free PMC Article
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard?
Lambrecht J, Verhulst S, Mannaerts I, Reynaert H, van Grunsven LA
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt A):1024-1036. Epub 2018 Jan 9 doi: 10.1016/j.bbadis.2018.01.009. PMID: 29329986
Hippo pathway regulation of gastrointestinal tissues.
Yu FX, Meng Z, Plouffe SW, Guan KL
Annu Rev Physiol 2015;77:201-27. Epub 2014 Sep 29 doi: 10.1146/annurev-physiol-021014-071733. PMID: 25293527
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Recent systematic reviews

Incidence of immunotherapy-related hyperprogressive disease (HPD) across HPD definitions and cancer types in observational studies: A systematic review and meta-analysis.
Kim MJ, Hong SPD, Park Y, Chae YK
Cancer Med 2024 Feb;13(3):e6970. doi: 10.1002/cam4.6970. PMID: 38400685Free PMC Article
Inhibition of the CD47-SIRPα axis for cancer therapy: A systematic review and meta-analysis of emerging clinical data.
Son J, Hsieh RC, Lin HY, Krause KJ, Yuan Y, Biter AB, Welsh J, Curran MA, Hong DS
Front Immunol 2022;13:1027235. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1027235. PMID: 36439116Free PMC Article
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review.
Van de Wiele C, Sathekge M, de Spiegeleer B, de Jonghe PJ, Beels L, Maes A
Int J Mol Sci 2019 Oct 2;20(19) doi: 10.3390/ijms20194886. PMID: 31581638Free PMC Article
Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.
Zhang Q, Wang Q, Sun W, Gao F, Liu L, Cheng L, Li Z
Biomed Res Int 2018;2018:6124927. Epub 2018 Nov 25 doi: 10.1155/2018/6124927. PMID: 30596096Free PMC Article
Hormonal contraceptive use among women with liver tumors: a systematic review.
Kapp N, Curtis KM
Contraception 2009 Oct;80(4):387-90. Epub 2009 Jun 10 doi: 10.1016/j.contraception.2009.01.021. PMID: 19751862

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