U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Liver Neuroendocrine Neoplasm

MedGen UID:
474663
•Concept ID:
C3273030
•
Neoplastic Process
Synonyms: Hepatic Neuroendocrine Neoplasm; Primary Hepatic Neuroendocrine Neoplasm; Primary Liver Neuroendocrine Neoplasm

Definition

An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms). [from NCI]

Professional guidelines

PubMed

Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Management of neuroendocrine tumor liver metastases.
Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Small bowel neuroendocrine neoplasm: what surgeons want to know.
Gupta A, Lubner MG, Liu JB, Richards ES, Pickhardt PJ
Abdom Radiol (NY) 2022 Dec;47(12):4005-4015. Epub 2022 Mar 21 doi: 10.1007/s00261-022-03485-6. PMID: 35312820
Evaluation of Outcomes Following Surgery for Locally Advanced Pancreatic Neuroendocrine Tumors.
Titan AL, Norton JA, Fisher AT, Foster DS, Harris EJ, Worhunsky DJ, Worth PJ, Dua MM, Visser BC, Poultsides GA, Longaker MT, Jensen RT
JAMA Netw Open 2020 Nov 2;3(11):e2024318. doi: 10.1001/jamanetworkopen.2020.24318. PMID: 33146734Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

Diagnosis

Diagnosis and management of neuroendocrine tumours.
Cuthbertson DJ, Shankland R, Srirajaskanthan R
Clin Med (Lond) 2023 Mar;23(2):119-124. doi: 10.7861/clinmed.2023-0044. PMID: 36958842Free PMC Article
Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes.
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845

Therapy

Liver-Directed Therapies for Neuroendocrine Neoplasms.
Clift AK, Frilling A
Curr Oncol Rep 2021 Mar 15;23(4):44. doi: 10.1007/s11912-021-01030-0. PMID: 33721122
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845
Pancreatic neuroendocrine neoplasms.
Hörsch D, Bert T, Schrader J, Hommann M, Kaemmerer D, Petrovitch A, Zaknun J, Baum RP
Minerva Gastroenterol Dietol 2012 Dec;58(4):401-26. PMID: 23207615
Neuroendocrine liver metastases.
Reddy SK, Clary BM
Surg Clin North Am 2010 Aug;90(4):853-61. Epub 2010 Jun 9 doi: 10.1016/j.suc.2010.04.016. PMID: 20637952

Prognosis

Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845
Pancreatic neuroendocrine neoplasms.
Hörsch D, Bert T, Schrader J, Hommann M, Kaemmerer D, Petrovitch A, Zaknun J, Baum RP
Minerva Gastroenterol Dietol 2012 Dec;58(4):401-26. PMID: 23207615
Lymph nodes and survival in pancreatic neuroendocrine tumors.
Krampitz GW, Norton JA, Poultsides GA, Visser BC, Sun L, Jensen RT
Arch Surg 2012 Sep;147(9):820-7. doi: 10.1001/archsurg.2012.1261. PMID: 22987171Free PMC Article

Clinical prediction guides

Clinical and pathological profile of gastric neuroendocrine tumors.
Sekar A, Vaiphei K
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):551-557. doi: 10.4103/ijpm.ijpm_824_21. PMID: 35900481
Evaluation of Outcomes Following Surgery for Locally Advanced Pancreatic Neuroendocrine Tumors.
Titan AL, Norton JA, Fisher AT, Foster DS, Harris EJ, Worhunsky DJ, Worth PJ, Dua MM, Visser BC, Poultsides GA, Longaker MT, Jensen RT
JAMA Netw Open 2020 Nov 2;3(11):e2024318. doi: 10.1001/jamanetworkopen.2020.24318. PMID: 33146734Free PMC Article
Surgical Management of Pancreatic Neuroendocrine Tumors.
Vaghaiwalla T, Keutgen XM
Surg Oncol Clin N Am 2020 Apr;29(2):243-252. doi: 10.1016/j.soc.2019.11.008. PMID: 32151358
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Recent systematic reviews

Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis.
Cigrovski Berkovic M, Coppola A, Sesa V, Mrzljak A, Lai Q
World J Gastroenterol 2024 Feb 21;30(7):759-769. doi: 10.3748/wjg.v30.i7.759. PMID: 38515954Free PMC Article
Management of neuroendocrine tumor liver metastases.
Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
Treatment strategies for neuroendocrine liver metastases: a systematic review.
Muttillo EM, Mazzarella G, Picardi B, Rossi S, Cinelli L, Diana M, Baiocchini A, Felli E, Pessaux P, Felli E, Muttillo IA
HPB (Oxford) 2022 Nov;24(11):1832-1843. Epub 2022 Jun 21 doi: 10.1016/j.hpb.2022.06.009. PMID: 35794053
Liver transplantation in patients with liver metastases from neuroendocrine tumors: A systematic review.
Moris D, Tsilimigras DI, Ntanasis-Stathopoulos I, Beal EW, Felekouras E, Vernadakis S, Fung JJ, Pawlik TM
Surgery 2017 Sep;162(3):525-536. Epub 2017 Jun 16 doi: 10.1016/j.surg.2017.05.006. PMID: 28624178
Liver transplantation for neuroendocrine tumour liver metastases.
Fan ST, Le Treut YP, Mazzaferro V, Burroughs AK, Olausson M, Breitenstein S, Frilling A
HPB (Oxford) 2015 Jan;17(1):23-8. Epub 2014 Jul 3 doi: 10.1111/hpb.12308. PMID: 24992381Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...