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Gallbladder Mucinous Cystic Neoplasm, High Grade

MedGen UID:
474734
•Concept ID:
C3273101
•
Neoplastic Process
Synonyms: Gallbladder MCN with High Grade Intraepithelial Neoplasia; Gallbladder Mucinous Cystic Neoplasm with High Grade Intraepithelial Neoplasia; Gallbladder Mucinous Cystic Neoplasm, High-Grade

Definition

A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium. It is characterized by the presence of severe atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Mucinous Cystic Neoplasm, High Grade

Recent clinical studies

Etiology

Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Intrahepatic biliary intraductal papillary mucinous neoplasm with gallbladder agenesis: case report.
Kim BS, Joo SH, Lim SJ, Joo KR
Surg Laparosc Endosc Percutan Tech 2013 Apr;23(2):e61-4. doi: 10.1097/SLE.0b013e31824a7e6c. PMID: 23579531

Diagnosis

Late Development of Metastatic Ovarian Mucinous Adenocarcinoma From Primary Gallblader Adenocarcinoma and High-grade Dysplasia.
Taylor J, Shah R, McElvanna K, Kelly PJ, McCluggage WG
Int J Gynecol Pathol 2021 Jan;40(1):41-48. doi: 10.1097/PGP.0000000000000681. PMID: 32897957
A case of mucinous cystic neoplasm of the gallbladder.
Sugawara S, Hirai I, Watanabe T, Tezuka K, Kimura W
Clin J Gastroenterol 2018 Oct;11(5):428-432. Epub 2018 Mar 13 doi: 10.1007/s12328-018-0850-8. PMID: 29536429
SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type.
Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT
Am J Surg Pathol 2016 Mar;40(3):419-32. doi: 10.1097/PAS.0000000000000553. PMID: 26551622
Intrahepatic biliary intraductal papillary mucinous neoplasm with gallbladder agenesis: case report.
Kim BS, Joo SH, Lim SJ, Joo KR
Surg Laparosc Endosc Percutan Tech 2013 Apr;23(2):e61-4. doi: 10.1097/SLE.0b013e31824a7e6c. PMID: 23579531
Intrahepatic biliary intraductal papillary mucinous neoplasm with gallbladder agenesis: case report.
Kim BS, Joo SH, Lim SJ, Joo KR
Surg Laparosc Endosc Percutan Tech 2012 Oct;22(5):e277-80. doi: 10.1097/SLE.0b013e31824a7e6c. PMID: 23047406

Prognosis

SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type.
Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT
Am J Surg Pathol 2016 Mar;40(3):419-32. doi: 10.1097/PAS.0000000000000553. PMID: 26551622
Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Intrahepatic biliary intraductal papillary mucinous neoplasm with gallbladder agenesis: case report.
Kim BS, Joo SH, Lim SJ, Joo KR
Surg Laparosc Endosc Percutan Tech 2013 Apr;23(2):e61-4. doi: 10.1097/SLE.0b013e31824a7e6c. PMID: 23579531

Clinical prediction guides

SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type.
Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT
Am J Surg Pathol 2016 Mar;40(3):419-32. doi: 10.1097/PAS.0000000000000553. PMID: 26551622

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