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Surfactant Protein D Deficiency

MedGen UID:
476154
•Concept ID:
C3274521
•
Disease or Syndrome

Definition

Deficiency of surfactant protein D. When present in normal amounts, this protein offers protection against pulmonary infection and inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSurfactant Protein D Deficiency

Professional guidelines

PubMed

Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation.
Fakih D, Pilecki B, Schlosser A, Jepsen CS, Thomsen LK, Ormhøj M, Watson A, Madsen J, Clark HW, Barfod KK, Hansen S, Marcussen N, Jounblat R, Chamat S, Holmskov U, Sorensen GL
Am J Physiol Lung Cell Mol Physiol 2015 Dec 1;309(11):L1333-43. Epub 2015 Oct 2 doi: 10.1152/ajplung.00090.2015. PMID: 26432866

Recent clinical studies

Therapy

Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis.
Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, Nielsen CH, Vestbo J, Palaniyar N, Holmskov U, Sorensen GL
Front Immunol 2018;9:3013. Epub 2018 Dec 18 doi: 10.3389/fimmu.2018.03013. PMID: 30619359Free PMC Article

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    Practice guidelines

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