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Allergic bronchopulmonary aspergillosis

MedGen UID:
479932
•Concept ID:
C3278302
•
Disease or Syndrome
Synonym: ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS, FAMILIAL
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015243
OMIM®: 103920
Orphanet: ORPHA1164

Definition

A rare immunologic pulmonary disorder caused by hypersensitivity to <i>Aspergillus fumigatus</i>, clinically manifesting with poorly controlled asthma and recurrent pulmonary infiltrates. [from ORDO]

Clinical features

From HPO
Abnormality of the immune system
MedGen UID:
867388
•Concept ID:
C4021753
•
Pathologic Function
An abnormality of the immune system.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergic bronchopulmonary aspergillosis

Professional guidelines

PubMed

Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review.
Echeverria-Esnal D, Martín-Ontiyuelo C, Navarrete-Rouco ME, Barcelo-Vidal J, Conde-Estévez D, Carballo N, De-Antonio Cuscó M, Ferrández O, Horcajada JP, Grau S
Expert Rev Anti Infect Ther 2022 Feb;20(2):179-197. Epub 2021 Aug 18 doi: 10.1080/14787210.2021.1962292. PMID: 34328373
New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation.
Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J, Okada N, Tanaka J, Fukutomi Y, Ueki S, Fukunaga K, Konno S, Matsuse H, Kamei K, Taniguchi M, Shimoda T, Oguma T; Japan ABPM Research Program
J Allergy Clin Immunol 2021 Apr;147(4):1261-1268.e5. Epub 2020 Sep 10 doi: 10.1016/j.jaci.2020.08.029. PMID: 32920094
Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.
Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis JF, Guleria R, Moss R, Denning DW; ABPA complicating asthma ISHAM working group
Clin Exp Allergy 2013 Aug;43(8):850-73. doi: 10.1111/cea.12141. PMID: 23889240

Recent clinical studies

Etiology

Allergic bronchopulmonary aspergillosis: A multidisciplinary review.
Roboubi A, Audousset C, Fréalle É, Brun AL, Laurent F, Vitte J, Mortuaire G, Lefevre G, Cadranel J, Chenivesse C
J Mycol Med 2023 Aug;33(3):101392. Epub 2023 May 4 doi: 10.1016/j.mycmed.2023.101392. PMID: 37172543
Allergic bronchopulmonary aspergillosis.
Agarwal R, Sehgal IS, Dhooria S, Muthu V, Prasad KT, Bal A, Aggarwal AN, Chakrabarti A
Indian J Med Res 2020 Jun;151(6):529-549. doi: 10.4103/ijmr.IJMR_1187_19. PMID: 32719226Free PMC Article
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, Ullmann AJ, Dimopoulos G, Lange C; European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Eur Respir J 2016 Jan;47(1):45-68. doi: 10.1183/13993003.00583-2015. PMID: 26699723
The clinical spectrum of pulmonary aspergillosis.
Kosmidis C, Denning DW
Thorax 2015 Mar;70(3):270-7. Epub 2014 Oct 29 doi: 10.1136/thoraxjnl-2014-206291. PMID: 25354514

Diagnosis

Allergic Bronchopulmonary Aspergillosis.
Agarwal R, Muthu V, Sehgal IS, Dhooria S, Prasad KT, Aggarwal AN
Clin Chest Med 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002. PMID: 35236565
Allergic bronchopulmonary aspergillosis.
Agarwal R, Sehgal IS, Dhooria S, Muthu V, Prasad KT, Bal A, Aggarwal AN, Chakrabarti A
Indian J Med Res 2020 Jun;151(6):529-549. doi: 10.4103/ijmr.IJMR_1187_19. PMID: 32719226Free PMC Article
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.
Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis JF, Guleria R, Moss R, Denning DW; ABPA complicating asthma ISHAM working group
Clin Exp Allergy 2013 Aug;43(8):850-73. doi: 10.1111/cea.12141. PMID: 23889240

Therapy

Allergic bronchopulmonary aspergillosis: A multidisciplinary review.
Roboubi A, Audousset C, Fréalle É, Brun AL, Laurent F, Vitte J, Mortuaire G, Lefevre G, Cadranel J, Chenivesse C
J Mycol Med 2023 Aug;33(3):101392. Epub 2023 May 4 doi: 10.1016/j.mycmed.2023.101392. PMID: 37172543
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, Ullmann AJ, Dimopoulos G, Lange C; European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Eur Respir J 2016 Jan;47(1):45-68. doi: 10.1183/13993003.00583-2015. PMID: 26699723
The clinical spectrum of pulmonary aspergillosis.
Kosmidis C, Denning DW
Thorax 2015 Mar;70(3):270-7. Epub 2014 Oct 29 doi: 10.1136/thoraxjnl-2014-206291. PMID: 25354514

Prognosis

Endotypes in bronchiectasis: moving towards precision medicine. A narrative review.
Martins M, Keir HR, Chalmers JD
Pulmonology 2023 Nov-Dec;29(6):505-517. Epub 2023 Apr 6 doi: 10.1016/j.pulmoe.2023.03.004. PMID: 37030997
Omalizumab in Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis.
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Allergic Bronchopulmonary Aspergillosis.
Agarwal R, Muthu V, Sehgal IS, Dhooria S, Prasad KT, Aggarwal AN
Clin Chest Med 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002. PMID: 35236565
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Clinical prediction guides

Endotypes in bronchiectasis: moving towards precision medicine. A narrative review.
Martins M, Keir HR, Chalmers JD
Pulmonology 2023 Nov-Dec;29(6):505-517. Epub 2023 Apr 6 doi: 10.1016/j.pulmoe.2023.03.004. PMID: 37030997
Omalizumab in Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis.
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
The clinical spectrum of pulmonary aspergillosis.
Kosmidis C, Denning DW
Thorax 2015 Mar;70(3):270-7. Epub 2014 Oct 29 doi: 10.1136/thoraxjnl-2014-206291. PMID: 25354514
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article
Aspergillus fumigatus and aspergillosis.
Latgé JP
Clin Microbiol Rev 1999 Apr;12(2):310-50. doi: 10.1128/CMR.12.2.310. PMID: 10194462Free PMC Article

Recent systematic reviews

Omalizumab in Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis.
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis.
Francis NZ, Southern KW
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD002204. doi: 10.1002/14651858.CD002204.pub5. PMID: 36053129Free PMC Article
Intermittent prophylactic antibiotics for bronchiectasis.
Spencer S, Donovan T, Chalmers JD, Mathioudakis AG, McDonnell MJ, Tsang A, Leadbetter P
Cochrane Database Syst Rev 2022 Jan 5;1(1):CD013254. doi: 10.1002/14651858.CD013254.pub2. PMID: 34985761Free PMC Article
Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis.
Jat KR, Walia DK, Khairwa A
Cochrane Database Syst Rev 2021 Sep 22;9(9):CD010288. doi: 10.1002/14651858.CD010288.pub5. PMID: 34550603Free PMC Article
Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis.
Agarwal R, Sehgal IS, Dhooria S, Aggarwal AN
Expert Rev Respir Med 2016 Dec;10(12):1317-1334. Epub 2016 Nov 7 doi: 10.1080/17476348.2016.1249853. PMID: 27744712

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