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Renal fibrosis

MedGen UID:
508798
Concept ID:
C0151650
Disease or Syndrome
Synonyms: Kidney fibrosis; renal fibrosis
SNOMED CT: Renal fibrosis (197660000)
 
HPO: HP:0030760
Monarch Initiative: MONDO:0000494

Definition

Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease. [from HPO]

Conditions with this feature

Joubert syndrome 35
MedGen UID:
1648453
Concept ID:
C4748442
Disease or Syndrome
Joubert syndrome-35 (JBTS35) is an autosomal recessive disorder characterized by brain malformations that result in developmental delay, oculomotor apraxia, and hypotonia. Some patients have renal and retinal involvement (Alkanderi et al., 2018). For a discussion of genetic heterogeneity of Joubert syndrome, see JBTS1 (213300).

Professional guidelines

PubMed

Fu S, Zhou Y, Hu C, Xu Z, Hou J
BMC Complement Med Ther 2022 Aug 6;22(1):210. doi: 10.1186/s12906-022-03662-6. PMID: 35932042Free PMC Article
Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, Zhuang S, Liu N
Cell Death Dis 2020 Jun 17;11(6):467. doi: 10.1038/s41419-020-2673-z. PMID: 32555189Free PMC Article
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908

Recent clinical studies

Etiology

Song A, Zhang C, Meng X
Biomed Pharmacother 2021 Jun;138:111454. Epub 2021 Mar 11 doi: 10.1016/j.biopha.2021.111454. PMID: 33714781
Jiang M, Bai M, Lei J, Xie Y, Xu S, Jia Z, Zhang A
Am J Physiol Renal Physiol 2020 Dec 1;319(6):F1105-F1116. Epub 2020 Oct 19 doi: 10.1152/ajprenal.00285.2020. PMID: 33073587
Su HY, Yang C, Liang D, Liu HF
Biomed Res Int 2020;2020:5817348. Epub 2020 Jun 26 doi: 10.1155/2020/5817348. PMID: 32685502Free PMC Article
Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H
J Nephrol 2020 Dec;33(6):1171-1187. Epub 2020 Jul 10 doi: 10.1007/s40620-020-00793-2. PMID: 32651850
Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F
Gut 2020 Dec;69(12):2131-2142. Epub 2020 Apr 2 doi: 10.1136/gutjnl-2019-319766. PMID: 32241904Free PMC Article

Diagnosis

Puthumana J, Thiessen-Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J, Bhatraju PK, Ikizler TA, Siew ED, Ware LB, Liu KD, Go AS, Kaufman JS, Kimmel PL, Chinchilli VM, Cantley LG, Parikh CR
J Clin Invest 2021 Feb 1;131(3) doi: 10.1172/JCI139927. PMID: 33290282Free PMC Article
Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H
J Nephrol 2020 Dec;33(6):1171-1187. Epub 2020 Jul 10 doi: 10.1007/s40620-020-00793-2. PMID: 32651850
Meng XM
Adv Exp Med Biol 2019;1165:381-406. doi: 10.1007/978-981-13-8871-2_18. PMID: 31399975
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908
Schnaper HW
Methods Mol Med 2005;117:45-68. doi: 10.1385/1-59259-940-0:045. PMID: 16118445

Therapy

Alugoju P, Krishna Swamy VKD, Anthikapalli NVA, Tencomnao T
Crit Rev Food Sci Nutr 2023;63(31):10709-10774. Epub 2022 Jun 16 doi: 10.1080/10408398.2022.2084600. PMID: 35708049
Yao W, Chen Y, Li Z, Ji J, You A, Jin S, Ma Y, Zhao Y, Wang J, Qu L, Wang H, Xiang C, Wang S, Liu G, Bai F, Yang L
Adv Sci (Weinh) 2022 Apr;9(12):e2103675. Epub 2022 Feb 3 doi: 10.1002/advs.202103675. PMID: 35112806Free PMC Article
Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F
Gut 2020 Dec;69(12):2131-2142. Epub 2020 Apr 2 doi: 10.1136/gutjnl-2019-319766. PMID: 32241904Free PMC Article
Geng XQ, Ma A, He JZ, Wang L, Jia YL, Shao GY, Li M, Zhou H, Lin SQ, Ran JH, Yang BX
Acta Pharmacol Sin 2020 May;41(5):670-677. Epub 2019 Dec 5 doi: 10.1038/s41401-019-0324-7. PMID: 31804606Free PMC Article
Li R, Guo Y, Zhang Y, Zhang X, Zhu L, Yan T
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051103. PMID: 30836660Free PMC Article

Prognosis

Kadowaki T, Maegawa H, Watada H, Yabe D, Node K, Murohara T, Wada J
Diabetes Obes Metab 2022 Dec;24(12):2283-2296. Epub 2022 Aug 25 doi: 10.1111/dom.14829. PMID: 35929483Free PMC Article
Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV
Cell Metab 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465Free PMC Article
Korbecki J, Bajdak-Rusinek K, Kupnicka P, Kapczuk P, Simińska D, Chlubek D, Baranowska-Bosiacka I
Int J Mol Sci 2021 Mar 28;22(7) doi: 10.3390/ijms22073490. PMID: 33800554Free PMC Article
Docherty MH, O'Sullivan ED, Bonventre JV, Ferenbach DA
J Am Soc Nephrol 2019 May;30(5):726-736. Epub 2019 Apr 18 doi: 10.1681/ASN.2018121251. PMID: 31000567Free PMC Article
Liu Y
Nat Rev Nephrol 2011 Oct 18;7(12):684-96. doi: 10.1038/nrneph.2011.149. PMID: 22009250Free PMC Article

Clinical prediction guides

Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H
J Nephrol 2020 Dec;33(6):1171-1187. Epub 2020 Jul 10 doi: 10.1007/s40620-020-00793-2. PMID: 32651850
Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K
Cell Metab 2019 Oct 1;30(4):784-799.e5. Epub 2019 Aug 29 doi: 10.1016/j.cmet.2019.08.003. PMID: 31474566Free PMC Article
Martínez-Klimova E, Aparicio-Trejo OE, Tapia E, Pedraza-Chaverri J
Biomolecules 2019 Apr 8;9(4) doi: 10.3390/biom9040141. PMID: 30965656Free PMC Article
Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K
Nat Med 2015 Jan;21(1):37-46. Epub 2014 Dec 1 doi: 10.1038/nm.3762. PMID: 25419705Free PMC Article
Liu Y
Nat Rev Nephrol 2011 Oct 18;7(12):684-96. doi: 10.1038/nrneph.2011.149. PMID: 22009250Free PMC Article

Recent systematic reviews

Zhang M, Tong Z, Wang Y, Fu W, Meng Y, Huang J, Sun L
J Drug Target 2023 Sep;31(8):858-866. Epub 2023 Aug 23 doi: 10.1080/1061186X.2023.2250574. PMID: 37607069
Cao H, Ke B, Lin F, Xue Y, Fang X
Ultrasound Med Biol 2023 May;49(5):1037-1048. Epub 2023 Feb 4 doi: 10.1016/j.ultrasmedbio.2023.01.003. PMID: 36746743
Tziastoudi M, Theoharides TC, Nikolaou E, Efthymiadi M, Eleftheriadis T, Stefanidis I
Int J Mol Sci 2022 Dec 5;23(23) doi: 10.3390/ijms232315331. PMID: 36499658Free PMC Article
Barinotti A, Radin M, Cecchi I, Foddai SG, Rubini E, Roccatello D, Sciascia S
Int J Mol Sci 2022 Nov 16;23(22) doi: 10.3390/ijms232214139. PMID: 36430625Free PMC Article
Mansour SG, Puthumana J, Coca SG, Gentry M, Parikh CR
BMC Nephrol 2017 Feb 20;18(1):72. doi: 10.1186/s12882-017-0490-0. PMID: 28219345Free PMC Article

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