U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Imperforate Vagina

MedGen UID:
539901
•Concept ID:
C0266414
•
Congenital Abnormality

Definition

A congenital birth defect characterized by the absence of a normal vaginal opening. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImperforate Vagina

Professional guidelines

PubMed

Imperforate Hymen: Clinical Pearls and Implications of Management.
Hamouie A, Dietrich JE
Clin Obstet Gynecol 2022 Dec 1;65(4):699-707. Epub 2022 Mar 11 doi: 10.1097/GRF.0000000000000703. PMID: 36260009
Diagnosis and Management of Hymenal Variants: ACOG Committee Opinion, Number 780.
Obstet Gynecol 2019 Jun;133(6):e372-e376. doi: 10.1097/AOG.0000000000003283. PMID: 31135763
Hydrometrocolpos etiology and management: past beckons the present.
Khanna K, Sharma S, Gupta DK
Pediatr Surg Int 2018 Mar;34(3):249-261. Epub 2017 Nov 24 doi: 10.1007/s00383-017-4218-9. PMID: 29177625

Recent clinical studies

Etiology

The Role of Patient Advocacy and the Declining Rate of Clitoroplasty in 46,XX Patients With Congenital Adrenal Hyperplasia.
Schoer MB, Nguyen PN, Merritt DF, Wesevich VG, Hollander AS
Clin Pediatr (Phila) 2018 Dec;57(14):1664-1671. Epub 2018 Sep 27 doi: 10.1177/0009922818803407. PMID: 30261740
Uterus bicornis bicollis, imperforate hemivagina and ipsilateral renal agenesis: case report and literature review.
DaCosta V, Christie L, Wynter S, Harriott J, Frederick J
West Indian Med J 2009 Sep;58(4):379-82. PMID: 20099781
Ocular and nonocular findings in patients with aniridia.
Valenzuela A, Cline RA
Can J Ophthalmol 2004 Oct;39(6):632-8. doi: 10.1016/s0008-4182(04)80028-0. PMID: 15559649

Diagnosis

High incidence of imperforate vagina in ADGRA3-deficient mice.
Kvam JM, Nybo ML, Torz L, Sustarsic RK, Jensen KHR, Nielsen JE, Frederiksen H, Gadgaard S, Spiess K, Poulsen SS, Thomsen JS, Cowin P, Blomberg Jensen M, Kurita T, Rosenkilde MM
BMC Biol 2024 Apr 8;22(1):77. doi: 10.1186/s12915-024-01873-6. PMID: 38589878Free PMC Article
Uterus bicornis bicollis, imperforate hemivagina and ipsilateral renal agenesis: case report and literature review.
DaCosta V, Christie L, Wynter S, Harriott J, Frederick J
West Indian Med J 2009 Sep;58(4):379-82. PMID: 20099781
Ocular and nonocular findings in patients with aniridia.
Valenzuela A, Cline RA
Can J Ophthalmol 2004 Oct;39(6):632-8. doi: 10.1016/s0008-4182(04)80028-0. PMID: 15559649
Uterine duplication, unilateral imperforate vagina, and normal kidneys.
Johnson J, Hillman BJ
AJR Am J Roentgenol 1986 Dec;147(6):1197-8. doi: 10.2214/ajr.147.6.1197. PMID: 3535455
Uterus didelphys with unilateral imperforate vagina and ipsilateral renal agenesis.
Miyazaki Y, Ebisuno S, Uekado Y, Ogawa T, Senzaki A, Ohkawa T
J Urol 1986 Jan;135(1):107-9. doi: 10.1016/s0022-5347(17)45533-9. PMID: 3510313

Therapy

Adhesion of the labia minora complicating circumcision in the neonatal period in a Nigerian community.
Diejomaoh FM, Faal MK
Trop Geogr Med 1981 Jun;33(2):135-8. PMID: 7281212

Prognosis

High incidence of imperforate vagina in ADGRA3-deficient mice.
Kvam JM, Nybo ML, Torz L, Sustarsic RK, Jensen KHR, Nielsen JE, Frederiksen H, Gadgaard S, Spiess K, Poulsen SS, Thomsen JS, Cowin P, Blomberg Jensen M, Kurita T, Rosenkilde MM
BMC Biol 2024 Apr 8;22(1):77. doi: 10.1186/s12915-024-01873-6. PMID: 38589878Free PMC Article

Clinical prediction guides

High incidence of imperforate vagina in ADGRA3-deficient mice.
Kvam JM, Nybo ML, Torz L, Sustarsic RK, Jensen KHR, Nielsen JE, Frederiksen H, Gadgaard S, Spiess K, Poulsen SS, Thomsen JS, Cowin P, Blomberg Jensen M, Kurita T, Rosenkilde MM
BMC Biol 2024 Apr 8;22(1):77. doi: 10.1186/s12915-024-01873-6. PMID: 38589878Free PMC Article
Ocular and nonocular findings in patients with aniridia.
Valenzuela A, Cline RA
Can J Ophthalmol 2004 Oct;39(6):632-8. doi: 10.1016/s0008-4182(04)80028-0. PMID: 15559649
Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome.
Cano-Gauci DF, Song HH, Yang H, McKerlie C, Choo B, Shi W, Pullano R, Piscione TD, Grisaru S, Soon S, Sedlackova L, Tanswell AK, Mak TW, Yeger H, Lockwood GA, Rosenblum ND, Filmus J
J Cell Biol 1999 Jul 12;146(1):255-64. doi: 10.1083/jcb.146.1.255. PMID: 10402475Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...