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Mediastinal cancer

MedGen UID:
56308
•Concept ID:
C0153504
•
Neoplastic Process
Synonyms: Cancer of Mediastinum; Cancer of the Mediastinum; Cancer, Mediastinal; Cancer, Mediastinum; Cancers, Mediastinal; Cancers, Mediastinum; Mediastinal Cancer; Mediastinal Cancers; Mediastinum Cancer; Mediastinum Cancers
SNOMED CT: Malignant neoplasm of mediastinum (363494000); Malignant mediastinal tumor (363494000); Malignant tumor of mediastinum (363494000)
 
Monarch Initiative: MONDO:0005843

Definition

A primary or metastatic malignant neoplasm affecting the mediastinum. Representative examples of primary malignant mediastinal neoplasms include malignant germ cell tumors, malignant mesenchymal tumors, lymphomas, and malignant peripheral nerve sheath tumors. A representative example of metastatic malignant neoplasm to the mediastinum is the metastatic carcinoma to the mediastinum from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal cancer

Professional guidelines

PubMed

Management of Ground-Glass Opacities in the Lung Cancer Spectrum.
Zhang Y, Fu F, Chen H
Ann Thorac Surg 2020 Dec;110(6):1796-1804. Epub 2020 Jun 7 doi: 10.1016/j.athoracsur.2020.04.094. PMID: 32525031
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Treatment of Mediastinal Endometrial Carcinoma Developed from Extragenital Endometriosis and Simultaneous Rectal Adenocarcinoma in a 55-year-old Woman.
Dorman K, Zhang D, Kunz WG, Angele M, Neumann J, Burges A, VON Bergwelt-Baildon M, Heinemann V, Boeck S, Giessen-Jung C
Anticancer Res 2023 Apr;43(4):1857-1861. doi: 10.21873/anticanres.16340. PMID: 36974819
Extracorporeal life support and cardiopulmonary bypass for central airway surgery: A systematic review.
O'Malley TJ, Yost CC, Prochno KW, Saxena A, Grenda TR, Evans NR, Cowan SW, Morris RJ, Massey HT, Tchantchaleishvili V
Artif Organs 2022 Mar;46(3):362-374. Epub 2021 Nov 16 doi: 10.1111/aor.14084. PMID: 34633690
A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.
Tang W, Li X, Yu H, Yin X, Zou B, Zhang T, Chen J, Sun X, Liu N, Yu J, Xie P
BMC Cancer 2021 May 22;21(1):585. doi: 10.1186/s12885-021-08264-y. PMID: 34022830Free PMC Article
Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease.
Chiang CL, Hu YW, Wu CH, Chen YT, Liu CJ, Luo YH, Chen YM, Chen TJ, Su KC, Chou KT
Int J Clin Oncol 2016 Oct;21(5):1014-1020. Epub 2016 May 6 doi: 10.1007/s10147-016-0983-z. PMID: 27154177
Cervico-mediastinal extension of thyroid cancer.
Torre GC, Ansaldo GL, Borgonovo G, Varaldo E, Meola C, Bottaro P, Minuto M, Mattioli FP
Am Surg 2000 May;66(5):487-90. PMID: 10824751

Diagnosis

Treatment of Mediastinal Endometrial Carcinoma Developed from Extragenital Endometriosis and Simultaneous Rectal Adenocarcinoma in a 55-year-old Woman.
Dorman K, Zhang D, Kunz WG, Angele M, Neumann J, Burges A, VON Bergwelt-Baildon M, Heinemann V, Boeck S, Giessen-Jung C
Anticancer Res 2023 Apr;43(4):1857-1861. doi: 10.21873/anticanres.16340. PMID: 36974819
A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.
Tang W, Li X, Yu H, Yin X, Zou B, Zhang T, Chen J, Sun X, Liu N, Yu J, Xie P
BMC Cancer 2021 May 22;21(1):585. doi: 10.1186/s12885-021-08264-y. PMID: 34022830Free PMC Article
National prevalence, trends and outcomes of takotsubo syndrome in hospitalizations with prior history of mediastinal/intrathoracic cancer and radiation therapy.
Desai R, Desai A, Abbas SA, Patel U, Bansod S, Damarlapally N, Doshi R, Savani S, Gangani K, Sachdeva R, Kumar G
Int J Cardiol 2020 Jun 15;309:14-18. Epub 2020 Feb 14 doi: 10.1016/j.ijcard.2020.02.036. PMID: 32087939
Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease.
Chiang CL, Hu YW, Wu CH, Chen YT, Liu CJ, Luo YH, Chen YM, Chen TJ, Su KC, Chou KT
Int J Clin Oncol 2016 Oct;21(5):1014-1020. Epub 2016 May 6 doi: 10.1007/s10147-016-0983-z. PMID: 27154177
Survival in cancer of unknown primary site: population-based analysis by site and histology.
Hemminki K, Bevier M, Hemminki A, Sundquist J
Ann Oncol 2012 Jul;23(7):1854-63. Epub 2011 Nov 24 doi: 10.1093/annonc/mdr536. PMID: 22115926

Therapy

A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.
Tang W, Li X, Yu H, Yin X, Zou B, Zhang T, Chen J, Sun X, Liu N, Yu J, Xie P
BMC Cancer 2021 May 22;21(1):585. doi: 10.1186/s12885-021-08264-y. PMID: 34022830Free PMC Article
Effect of compound Zhuye Shigao Granule ( ) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial.
Wang LJ, Lu JZ, Cai BN, Li MW, Qu BL
Chin J Integr Med 2017 Feb;23(2):98-104. Epub 2016 Dec 29 doi: 10.1007/s11655-016-2652-5. PMID: 28035542
Isolated cardiac metastasis from squamous cell esophageal cancer.
Abbate MI, Cicchiello F, Canova S, Cortinovis D, Mariani S, Maffini F, Bidoli P
Tumori 2015 Jul 24;101(4):e118-21. doi: 10.5301/tj.5000324. PMID: 26045127
Atrial flutter in a man with mediastinal cancer.
Hancock EW
Hosp Pract (1995) 1996 Jan 15;31(1):15-6, 20. PMID: 8595985
Esophagopleural fistula: an early and long-term complication after pneumonectomy.
Massard G, Ducrocq X, Hentz JG, Kessler R, Dumont P, Wihlm JM, Morand G
Ann Thorac Surg 1994 Nov;58(5):1437-40; discussion 1441. doi: 10.1016/0003-4975(94)91930-5. PMID: 7979671

Prognosis

Treatment of Mediastinal Endometrial Carcinoma Developed from Extragenital Endometriosis and Simultaneous Rectal Adenocarcinoma in a 55-year-old Woman.
Dorman K, Zhang D, Kunz WG, Angele M, Neumann J, Burges A, VON Bergwelt-Baildon M, Heinemann V, Boeck S, Giessen-Jung C
Anticancer Res 2023 Apr;43(4):1857-1861. doi: 10.21873/anticanres.16340. PMID: 36974819
A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.
Tang W, Li X, Yu H, Yin X, Zou B, Zhang T, Chen J, Sun X, Liu N, Yu J, Xie P
BMC Cancer 2021 May 22;21(1):585. doi: 10.1186/s12885-021-08264-y. PMID: 34022830Free PMC Article
Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease.
Chiang CL, Hu YW, Wu CH, Chen YT, Liu CJ, Luo YH, Chen YM, Chen TJ, Su KC, Chou KT
Int J Clin Oncol 2016 Oct;21(5):1014-1020. Epub 2016 May 6 doi: 10.1007/s10147-016-0983-z. PMID: 27154177
Isolated cardiac metastasis from squamous cell esophageal cancer.
Abbate MI, Cicchiello F, Canova S, Cortinovis D, Mariani S, Maffini F, Bidoli P
Tumori 2015 Jul 24;101(4):e118-21. doi: 10.5301/tj.5000324. PMID: 26045127
Survival in cancer of unknown primary site: population-based analysis by site and histology.
Hemminki K, Bevier M, Hemminki A, Sundquist J
Ann Oncol 2012 Jul;23(7):1854-63. Epub 2011 Nov 24 doi: 10.1093/annonc/mdr536. PMID: 22115926

Clinical prediction guides

A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.
Tang W, Li X, Yu H, Yin X, Zou B, Zhang T, Chen J, Sun X, Liu N, Yu J, Xie P
BMC Cancer 2021 May 22;21(1):585. doi: 10.1186/s12885-021-08264-y. PMID: 34022830Free PMC Article
Effect of compound Zhuye Shigao Granule ( ) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial.
Wang LJ, Lu JZ, Cai BN, Li MW, Qu BL
Chin J Integr Med 2017 Feb;23(2):98-104. Epub 2016 Dec 29 doi: 10.1007/s11655-016-2652-5. PMID: 28035542
Esophagopleural fistula: an early and long-term complication after pneumonectomy.
Massard G, Ducrocq X, Hentz JG, Kessler R, Dumont P, Wihlm JM, Morand G
Ann Thorac Surg 1994 Nov;58(5):1437-40; discussion 1441. doi: 10.1016/0003-4975(94)91930-5. PMID: 7979671

Recent systematic reviews

Extracorporeal life support and cardiopulmonary bypass for central airway surgery: A systematic review.
O'Malley TJ, Yost CC, Prochno KW, Saxena A, Grenda TR, Evans NR, Cowan SW, Morris RJ, Massey HT, Tchantchaleishvili V
Artif Organs 2022 Mar;46(3):362-374. Epub 2021 Nov 16 doi: 10.1111/aor.14084. PMID: 34633690

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