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Idiopathic anterior uveitis

MedGen UID:
573079
•Concept ID:
C0339315
•
Disease or Syndrome
Synonyms: idiopathic anterior uveitis; Idiopathic inflammation of anterior uveal tract
SNOMED CT: Idiopathic anterior uveitis (231947004); Idiopathic inflammation of anterior uveal tract (231947004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017256
Orphanet: ORPHA280914

Definition

A rare ophthalmic disorder characterized by intraocular inflammation with the anterior chamber as the predominant site of inflammation, without any identifiable etiology. Presenting symptoms are pain, redness, photophobia, and sometimes blurred vision. Signs on examination include anterior chamber cell and flare, limbal vascular injection, and keratic precipitates, among others. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic anterior uveitis
Follow this link to review classifications for Idiopathic anterior uveitis in Orphanet.

Professional guidelines

PubMed

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.
Angeles-Han ST, Lo MS, Henderson LA, Lerman MA, Abramson L, Cooper AM, Parsa MF, Zemel LS, Ronis T, Beukelman T, Cox E, Sen HN, Holland GN, Brunner HI, Lasky A, Rabinovich CE; Juvenile Idiopathic Arthritis Disease-Specific and Uveitis Subcommittee of the Childhood Arthritis Rheumatology and Research Alliance
Arthritis Care Res (Hoboken) 2019 Apr;71(4):482-491. doi: 10.1002/acr.23610. PMID: 29806733Free PMC Article

Recent clinical studies

Etiology

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.
Angeles-Han ST, Lo MS, Henderson LA, Lerman MA, Abramson L, Cooper AM, Parsa MF, Zemel LS, Ronis T, Beukelman T, Cox E, Sen HN, Holland GN, Brunner HI, Lasky A, Rabinovich CE; Juvenile Idiopathic Arthritis Disease-Specific and Uveitis Subcommittee of the Childhood Arthritis Rheumatology and Research Alliance
Arthritis Care Res (Hoboken) 2019 Apr;71(4):482-491. doi: 10.1002/acr.23610. PMID: 29806733Free PMC Article
A Focus on the Epidemiology of Uveitis.
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180
Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review.
Campanilho-Marques R, Bogas M, Ramos F, Santos MJ, Fonseca JE
Acta Reumatol Port 2014 Apr-Jun;39(2):116-22. PMID: 24879943
Uveitis and diabetes mellitus.
Rothova A, Meenken C, Michels RP, Kijlstra A
Am J Ophthalmol 1988 Jul 15;106(1):17-20. doi: 10.1016/s0002-9394(14)76381-0. PMID: 3394764

Diagnosis

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
A Focus on the Epidemiology of Uveitis.
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180
Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review.
Campanilho-Marques R, Bogas M, Ramos F, Santos MJ, Fonseca JE
Acta Reumatol Port 2014 Apr-Jun;39(2):116-22. PMID: 24879943
Viral anterior uveitis.
Jap A, Chee SP
Curr Opin Ophthalmol 2011 Nov;22(6):483-8. doi: 10.1097/ICU.0b013e32834be021. PMID: 21918442
Uveitis and diabetes mellitus.
Rothova A, Meenken C, Michels RP, Kijlstra A
Am J Ophthalmol 1988 Jul 15;106(1):17-20. doi: 10.1016/s0002-9394(14)76381-0. PMID: 3394764

Therapy

Long-term outcomes of small-incision cataract surgery in patients with uveitis.
Bhargava R, Pandey K, Mehta B
Indian J Ophthalmol 2022 Nov;70(11):3927-3932. doi: 10.4103/ijo.IJO_1571_22. PMID: 36308129Free PMC Article
Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany.
Heiligenhaus A, Klotsche J, Niewerth M, Horneff G, Ganser G, Haas JP, Minden K
Arthritis Res Ther 2020 Apr 15;22(1):81. doi: 10.1186/s13075-020-02166-3. PMID: 32293540Free PMC Article
Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.
Angeles-Han ST, Lo MS, Henderson LA, Lerman MA, Abramson L, Cooper AM, Parsa MF, Zemel LS, Ronis T, Beukelman T, Cox E, Sen HN, Holland GN, Brunner HI, Lasky A, Rabinovich CE; Juvenile Idiopathic Arthritis Disease-Specific and Uveitis Subcommittee of the Childhood Arthritis Rheumatology and Research Alliance
Arthritis Care Res (Hoboken) 2019 Apr;71(4):482-491. doi: 10.1002/acr.23610. PMID: 29806733Free PMC Article
Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression.
Sharon Y, Friling R, Luski M, Campoverde BQ, Amer R, Kramer M
Ocul Immunol Inflamm 2017 Dec;25(6):740-747. Epub 2016 Dec 12 doi: 10.1080/09273948.2016.1255341. PMID: 27937076
Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis.
Banaee T, Shafiee M, Alizadeh R, Naseri MH
Ocul Immunol Inflamm 2016 Jun;24(3):288-92. Epub 2016 May 16 doi: 10.3109/09273948.2014.970279. PMID: 27182691

Prognosis

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Long-term outcomes of small-incision cataract surgery in patients with uveitis.
Bhargava R, Pandey K, Mehta B
Indian J Ophthalmol 2022 Nov;70(11):3927-3932. doi: 10.4103/ijo.IJO_1571_22. PMID: 36308129Free PMC Article
A Focus on the Epidemiology of Uveitis.
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180
Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review.
Campanilho-Marques R, Bogas M, Ramos F, Santos MJ, Fonseca JE
Acta Reumatol Port 2014 Apr-Jun;39(2):116-22. PMID: 24879943
Anterior uveitis and hypopyon.
D'Alessandro LP, Forster DJ, Rao NA
Am J Ophthalmol 1991 Sep 15;112(3):317-21. doi: 10.1016/s0002-9394(14)76733-9. PMID: 1882942

Clinical prediction guides

Features of hemodynamic and immunological parameters in patients with recurrent uveitis complicated by hypertension, Fuchs heterochromic uveitis and Posner-Schlossman syndrome.
Khramenko NI, Velychko LM, Konovalova NV, Bogdanova OV, Gheorghe LD, Bobescu DV
Rom J Ophthalmol 2023 Jan-Mar;67(1):20-32. doi: 10.22336/rjo.2023.5. PMID: 37089809Free PMC Article
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-α for the Idiopathic Anterior Uveitis in Children.
Zelazowska-Rutkowska B, Mrugacz M, Cylwik B
Clin Lab 2017 Nov 1;63(11):1889-1895. doi: 10.7754/Clin.Lab.2017.170629. PMID: 29226649
Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis.
Banaee T, Shafiee M, Alizadeh R, Naseri MH
Ocul Immunol Inflamm 2016 Jun;24(3):288-92. Epub 2016 May 16 doi: 10.3109/09273948.2014.970279. PMID: 27182691
Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review.
Campanilho-Marques R, Bogas M, Ramos F, Santos MJ, Fonseca JE
Acta Reumatol Port 2014 Apr-Jun;39(2):116-22. PMID: 24879943
Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis.
Spagnolo P, Sato H, Marshall SE, Antoniou KM, Ahmad T, Wells AU, Ahad MA, Lightman S, du Bois RM, Welsh KI
Invest Ophthalmol Vis Sci 2007 Jul;48(7):3019-25. doi: 10.1167/iovs.06-1485. PMID: 17591867

Recent systematic reviews

Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review.
Campanilho-Marques R, Bogas M, Ramos F, Santos MJ, Fonseca JE
Acta Reumatol Port 2014 Apr-Jun;39(2):116-22. PMID: 24879943

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