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Disorder of glutamine metabolism

MedGen UID:
575171
•Concept ID:
C0342669
•
Disease or Syndrome
Synonyms: disorder of glutamine metabolism; Disturbance of glutamine metabolism
SNOMED CT: Disorder of glutamine metabolism (190724004); Disturbance of glutamine metabolism (190724004)
 
Monarch Initiative: MONDO:0017352
Orphanet: ORPHA289841

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of glutamine metabolism
Follow this link to review classifications for Disorder of glutamine metabolism in Orphanet.

Professional guidelines

PubMed

The Role of Ketogenic Diet in the Treatment of Neurological Diseases.
Dyńka D, Kowalcze K, Paziewska A
Nutrients 2022 Nov 24;14(23) doi: 10.3390/nu14235003. PMID: 36501033Free PMC Article
The vaso-occlusive pain crisis in sickle cell disease: Definition, pathophysiology, and management.
Darbari DS, Sheehan VA, Ballas SK
Eur J Haematol 2020 Sep;105(3):237-246. Epub 2020 May 19 doi: 10.1111/ejh.13430. PMID: 32301178
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257

Recent clinical studies

Etiology

Side effects of amino acid supplements.
Holeček M
Physiol Res 2022 Mar 25;71(1):29-45. Epub 2022 Jan 19 doi: 10.33549/physiolres.934790. PMID: 35043647Free PMC Article
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.
Yang WH, Qiu Y, Stamatatos O, Janowitz T, Lukey MJ
Trends Cancer 2021 Aug;7(8):790-804. Epub 2021 May 18 doi: 10.1016/j.trecan.2021.04.003. PMID: 34020912Free PMC Article
Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis.
Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM
Front Immunol 2021;12:652771. Epub 2021 Apr 2 doi: 10.3389/fimmu.2021.652771. PMID: 33868292Free PMC Article
Gut Microbiota and Cardiovascular Disease.
Witkowski M, Weeks TL, Hazen SL
Circ Res 2020 Jul 31;127(4):553-570. Epub 2020 Jul 30 doi: 10.1161/CIRCRESAHA.120.316242. PMID: 32762536Free PMC Article
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, Cajka T, Mohan ML, Li L, Wu Y, Funabashi M, Ramer-Tait AE, Naga Prasad SV, Fiehn O, Rey FE, Tang WHW, Fischbach MA, DiDonato JA, Hazen SL
Cell 2020 Mar 5;180(5):862-877.e22. doi: 10.1016/j.cell.2020.02.016. PMID: 32142679Free PMC Article

Diagnosis

Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality.
Nemet I, Li XS, Haghikia A, Li L, Wilcox J, Romano KA, Buffa JA, Witkowski M, Demuth I, König M, Steinhagen-Thiessen E, Bäckhed F, Fischbach MA, Tang WHW, Landmesser U, Hazen SL
Eur Heart J 2023 Aug 22;44(32):3085-3096. doi: 10.1093/eurheartj/ehad333. PMID: 37342006Free PMC Article
Cancer as a Metabolic Disorder.
Gyamfi J, Kim J, Choi J
Int J Mol Sci 2022 Jan 21;23(3) doi: 10.3390/ijms23031155. PMID: 35163079Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry.
Shao Y, Li T, Liu Z, Wang X, Xu X, Li S, Xu G, Le W
Mol Neurodegener 2021 Jan 23;16(1):4. doi: 10.1186/s13024-021-00425-8. PMID: 33485385Free PMC Article
Sickle Cell Disease: Monitoring, Current Treatment, and Therapeutics Under Development.
Hoppe C, Neumayr L
Hematol Oncol Clin North Am 2019 Jun;33(3):355-371. Epub 2019 Mar 28 doi: 10.1016/j.hoc.2019.01.014. PMID: 31030807

Therapy

Side effects of amino acid supplements.
Holeček M
Physiol Res 2022 Mar 25;71(1):29-45. Epub 2022 Jan 19 doi: 10.33549/physiolres.934790. PMID: 35043647Free PMC Article
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.
Yang WH, Qiu Y, Stamatatos O, Janowitz T, Lukey MJ
Trends Cancer 2021 Aug;7(8):790-804. Epub 2021 May 18 doi: 10.1016/j.trecan.2021.04.003. PMID: 34020912Free PMC Article
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation.
Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P
Nutrients 2018 Oct 23;10(11) doi: 10.3390/nu10111564. PMID: 30360490Free PMC Article
The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases.
Kim MH, Kim H
Int J Mol Sci 2017 May 12;18(5) doi: 10.3390/ijms18051051. PMID: 28498331Free PMC Article
Glutamine as an immunonutrient.
Kim H
Yonsei Med J 2011 Nov;52(6):892-7. doi: 10.3349/ymj.2011.52.6.892. PMID: 22028151Free PMC Article

Prognosis

Association between Human Blood Metabolome and the Risk of Alzheimer's Disease.
Sun L, Guo D, Jia Y, Shi M, Yang P, Wang Y, Liu F, Chen GC, Zhang Y, Zhu Z
Ann Neurol 2022 Nov;92(5):756-767. Epub 2022 Aug 15 doi: 10.1002/ana.26464. PMID: 35899678
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle.
Andersen JV, Schousboe A, Verkhratsky A
Prog Neurobiol 2022 Oct;217:102331. Epub 2022 Jul 21 doi: 10.1016/j.pneurobio.2022.102331. PMID: 35872221
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK
Gastroenterology 2021 Nov;161(5):1584-1600. Epub 2021 Jul 8 doi: 10.1053/j.gastro.2021.06.045. PMID: 34245764Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI
Nat Commun 2020 Mar 17;11(1):1320. doi: 10.1038/s41467-020-15136-9. PMID: 32184390Free PMC Article

Clinical prediction guides

Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study.
He R, Zheng R, Zheng J, Li M, Wang T, Zhao Z, Wang S, Lin H, Lu J, Chen Y, Xu Y, Wang W, Xu M, Bi Y, Ning G
J Clin Endocrinol Metab 2023 May 17;108(6):1432-1441. doi: 10.1210/clinem/dgac707. PMID: 36510667Free PMC Article
Association between Human Blood Metabolome and the Risk of Alzheimer's Disease.
Sun L, Guo D, Jia Y, Shi M, Yang P, Wang Y, Liu F, Chen GC, Zhang Y, Zhu Z
Ann Neurol 2022 Nov;92(5):756-767. Epub 2022 Aug 15 doi: 10.1002/ana.26464. PMID: 35899678
Amino acid synthesis deficiencies.
de Koning TJ
J Inherit Metab Dis 2017 Jul;40(4):609-620. Epub 2017 Jun 26 doi: 10.1007/s10545-017-0063-1. PMID: 28653176Free PMC Article
Glutamine metabolism in advanced age.
Meynial-Denis D
Nutr Rev 2016 Apr;74(4):225-36. Epub 2016 Mar 2 doi: 10.1093/nutrit/nuv052. PMID: 26936258Free PMC Article
γ-Glutamylamines and neurodegenerative diseases.
Jeitner TM, Battaile K, Cooper AJ
Amino Acids 2013 Jan;44(1):129-42. Epub 2012 Mar 10 doi: 10.1007/s00726-011-1209-3. PMID: 22407484Free PMC Article

Recent systematic reviews

Functional MRS studies of GABA and glutamate/Glx - A systematic review and meta-analysis.
Pasanta D, He JL, Ford T, Oeltzschner G, Lythgoe DJ, Puts NA
Neurosci Biobehav Rev 2023 Jan;144:104940. Epub 2022 Nov 2 doi: 10.1016/j.neubiorev.2022.104940. PMID: 36332780Free PMC Article
Metabolomics in Glaucoma: A Systematic Review.
Wang Y, Hou XW, Liang G, Pan CW
Invest Ophthalmol Vis Sci 2021 May 3;62(6):9. doi: 10.1167/iovs.62.6.9. PMID: 33956051Free PMC Article
The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review.
Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, Hammad L, Riva A, Petrangolini G, Allegrini P, Rondanelli M
Int J Mol Sci 2019 Oct 22;20(20) doi: 10.3390/ijms20205232. PMID: 31652531Free PMC Article
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility.
Castaño M, Gómez-Gordo R, Cuevas D, Núñez C
Nutrients 2019 Aug 20;11(8) doi: 10.3390/nu11081950. PMID: 31434238Free PMC Article
A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder.
Chitty KM, Lagopoulos J, Lee RS, Hickie IB, Hermens DF
Eur Neuropsychopharmacol 2013 Nov;23(11):1348-63. Epub 2013 Aug 2 doi: 10.1016/j.euroneuro.2013.07.007. PMID: 23968965

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