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Gingival cancer

MedGen UID:
57549
•Concept ID:
C0153364
•
Neoplastic Process
Synonyms: CA - Cancer of gum; cancer of gingiva; Cancer of gum; gingiva cancer; gingival cancer; gum cancer; malignant gingiva neoplasm; Malignant Gingival Neoplasm; malignant gingival neoplasm; Malignant Gingival Tumor; malignant gingival tumor; malignant gingival tumour; Malignant Gum Neoplasm; malignant gum neoplasm; Malignant Gum Tumor; malignant gum tumor; malignant gum tumour; Malignant Neoplasm of Gingiva; malignant neoplasm of gingiva; Malignant Neoplasm of Gum; malignant neoplasm of gum; malignant neoplasm of other sites of gum; Malignant Neoplasm of the Gingiva; malignant neoplasm of the gingiva; Malignant Neoplasm of the Gum; malignant neoplasm of the gum; Malignant tumor of alveolar mucosa; Malignant tumor of gingiva; Malignant Tumor of Gingiva; malignant tumor of gingiva; Malignant tumor of gum; Malignant Tumor of Gum; malignant tumor of gum; Malignant Tumor of the Gingiva; malignant tumor of the gingiva; Malignant Tumor of the Gum; malignant tumor of the gum; malignant tumour of gingiva; malignant tumour of gum; malignant tumour of the gingiva; malignant tumour of the gum
SNOMED CT: Malignant tumor of alveolar mucosa (363382005); Malignant tumor of gingiva (363382005); Cancer of gum (363382005); CA - Cancer of gum (363382005); Malignant tumor of gum (363382005)
 
Monarch Initiative: MONDO:0005507

Definition

A primary or metastatic malignant neoplasm that affects the gums. [from NCI]

Professional guidelines

PubMed

PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells.
Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y, Kijima H
Eur J Cancer 2011 Jul;47(11):1747-58. Epub 2011 Apr 1 doi: 10.1016/j.ejca.2011.02.025. PMID: 21459569
Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using oligonucleotide microarrays.
Niedzielska I
Folia Biol (Praha) 2007;53(5):189-92. PMID: 17976310
Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using RT-PCR.
Niedzielska I, Sypniewski D, Mazurek U, Wilczok T, Niedzielski Z, Wziatek-Kuczmik D
Folia Biol (Praha) 2007;53(1):23-6. PMID: 17328839

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Prognostic factors for lymph node metastasis from upper gingival carcinomas.
Aldosimani M, Verdonschot RG, Iwamoto Y, Nakazawa M, Mallya SM, Kakimoto N, Toyosawa S, Kreiborg S, Murakami S
Oral Radiol 2022 Jul;38(3):389-396. Epub 2021 Sep 24 doi: 10.1007/s11282-021-00568-w. PMID: 34559370Free PMC Article
Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases.
Bagan J, Murillo-Cortes J, Leopoldo-Rodado M, Sanchis-Bielsa JM, Bagan L
J Periodontol 2019 Oct;90(10):1142-1148. Epub 2019 May 27 doi: 10.1002/JPER.18-0620. PMID: 31074011
Comparison of Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography and Computed Tomography for the Evaluation Bone Invasion in Upper and Lower Gingival Cancers.
Lee YC, Jung AR, Kwon OE, Kim EJ, Hong IK, Lee JW, Eun YG
J Oral Maxillofac Surg 2019 Apr;77(4):875.e1-875.e9. Epub 2018 Dec 22 doi: 10.1016/j.joms.2018.12.010. PMID: 30660446
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Cancer of the gingiva.
Bark R, Mercke C, Munck-Wikland E, Wisniewski NA, Hammarstedt-Nordenvall L
Eur Arch Otorhinolaryngol 2016 Jun;273(6):1335-45. Epub 2015 Feb 4 doi: 10.1007/s00405-015-3516-x. PMID: 25649283

Diagnosis

Gingival metastasis of a mediastinal pulmonary sarcomatoid carcinoma: a case report.
Qin Z, Huang B, Yu G, Zheng Y, Zhao K
J Cardiothorac Surg 2019 Sep 9;14(1):161. doi: 10.1186/s13019-019-0991-y. PMID: 31500651Free PMC Article
Comparison of Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography and Computed Tomography for the Evaluation Bone Invasion in Upper and Lower Gingival Cancers.
Lee YC, Jung AR, Kwon OE, Kim EJ, Hong IK, Lee JW, Eun YG
J Oral Maxillofac Surg 2019 Apr;77(4):875.e1-875.e9. Epub 2018 Dec 22 doi: 10.1016/j.joms.2018.12.010. PMID: 30660446
De Novo Malignancy Following Adult-to-Adult Living Donor Liver Transplantation Focusing on Posttransplantation Lymphoproliferative Disorder.
Mizuno S, Hayasaki A, Ito T, Fujii T, Iizawa Y, Kato H, Murata Y, Tanemura A, Kuriyama N, Azumi Y, Kishiwada M, Usui M, Sakurai H, Isaji S
Transplant Proc 2018 Nov;50(9):2699-2704. Epub 2018 Mar 15 doi: 10.1016/j.transproceed.2018.03.059. PMID: 30401380
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Cancer of the gingiva.
Bark R, Mercke C, Munck-Wikland E, Wisniewski NA, Hammarstedt-Nordenvall L
Eur Arch Otorhinolaryngol 2016 Jun;273(6):1335-45. Epub 2015 Feb 4 doi: 10.1007/s00405-015-3516-x. PMID: 25649283

Therapy

Utilization of a nanostructured lipid carrier encapsulating pitavastatin-Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line.
Felimban RI, Tayeb HH, Chaudhary AG, Felemban MA, Alnadwi FH, Ali SA, Alblowi JA, ALfayez E, Bukhary D, Alissa M, Qahl SH
Drug Deliv 2023 Dec;30(1):83-96. doi: 10.1080/10717544.2022.2155269. PMID: 36510636Free PMC Article
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Tension Pneumothorax After Percutaneous Tracheostomy.
Matsumura S, Kishimoto N, Iseki T, Momota Y
Anesth Prog 2017 Summer;64(2):85-87. doi: 10.2344/anpr-64-02-07. PMID: 28604085Free PMC Article
Anticancer effect of sirolimus in renal allograft recipients with de novo malignancies.
Boratyńska M, Watorek E, Smolska D, Patrzałek D, Klinger M
Transplant Proc 2007 Nov;39(9):2736-9. doi: 10.1016/j.transproceed.2007.08.078. PMID: 18021973
Smoking, gender, and age as risk factors for site-specific intraoral squamous cell carcinoma. A case-series analysis.
Barasch A, Morse DE, Krutchkoff DJ, Eisenberg E
Cancer 1994 Feb 1;73(3):509-13. doi: 10.1002/1097-0142(19940201)73:3<509::aid-cncr2820730303>3.0.co;2-x. PMID: 8299073

Prognosis

Prognostic factors for lymph node metastasis from upper gingival carcinomas.
Aldosimani M, Verdonschot RG, Iwamoto Y, Nakazawa M, Mallya SM, Kakimoto N, Toyosawa S, Kreiborg S, Murakami S
Oral Radiol 2022 Jul;38(3):389-396. Epub 2021 Sep 24 doi: 10.1007/s11282-021-00568-w. PMID: 34559370Free PMC Article
Comparison of Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography and Computed Tomography for the Evaluation Bone Invasion in Upper and Lower Gingival Cancers.
Lee YC, Jung AR, Kwon OE, Kim EJ, Hong IK, Lee JW, Eun YG
J Oral Maxillofac Surg 2019 Apr;77(4):875.e1-875.e9. Epub 2018 Dec 22 doi: 10.1016/j.joms.2018.12.010. PMID: 30660446
Metastasis of lower gingival squamous cell carcinoma to buccinator lymph node: case report and review of the literature.
Takada K, Kuroshima T, Shimamoto H, Ohsako T, Kayamori K, Ikeda T, Harada H
World J Surg Oncol 2019 Jan 10;17(1):13. doi: 10.1186/s12957-019-1559-y. PMID: 30630467Free PMC Article
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Cancer of the gingiva.
Bark R, Mercke C, Munck-Wikland E, Wisniewski NA, Hammarstedt-Nordenvall L
Eur Arch Otorhinolaryngol 2016 Jun;273(6):1335-45. Epub 2015 Feb 4 doi: 10.1007/s00405-015-3516-x. PMID: 25649283

Clinical prediction guides

Prognostic factors for lymph node metastasis from upper gingival carcinomas.
Aldosimani M, Verdonschot RG, Iwamoto Y, Nakazawa M, Mallya SM, Kakimoto N, Toyosawa S, Kreiborg S, Murakami S
Oral Radiol 2022 Jul;38(3):389-396. Epub 2021 Sep 24 doi: 10.1007/s11282-021-00568-w. PMID: 34559370Free PMC Article
Comparison of Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography and Computed Tomography for the Evaluation Bone Invasion in Upper and Lower Gingival Cancers.
Lee YC, Jung AR, Kwon OE, Kim EJ, Hong IK, Lee JW, Eun YG
J Oral Maxillofac Surg 2019 Apr;77(4):875.e1-875.e9. Epub 2018 Dec 22 doi: 10.1016/j.joms.2018.12.010. PMID: 30660446
De Novo Malignancy Following Adult-to-Adult Living Donor Liver Transplantation Focusing on Posttransplantation Lymphoproliferative Disorder.
Mizuno S, Hayasaki A, Ito T, Fujii T, Iizawa Y, Kato H, Murata Y, Tanemura A, Kuriyama N, Azumi Y, Kishiwada M, Usui M, Sakurai H, Isaji S
Transplant Proc 2018 Nov;50(9):2699-2704. Epub 2018 Mar 15 doi: 10.1016/j.transproceed.2018.03.059. PMID: 30401380
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Tension Pneumothorax After Percutaneous Tracheostomy.
Matsumura S, Kishimoto N, Iseki T, Momota Y
Anesth Prog 2017 Summer;64(2):85-87. doi: 10.2344/anpr-64-02-07. PMID: 28604085Free PMC Article

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

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    Reviews

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