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Tetanus neonatorum

MedGen UID:
575516
•Concept ID:
C0343312
•
Disease or Syndrome
Synonyms: Neonatal Tetanus; neonatal tetanus; Tetanus Neonatorum; tetanus neonatorum
SNOMED CT: Tetanus neonatorum (43424001)
 
Monarch Initiative: MONDO:0001737

Definition

A syndrome of generalized rigidity with muscle spasms and seizures in the neonatal period resulting from Clostridium tetani toxin production. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTetanus neonatorum

Professional guidelines

PubMed

Current concepts in the management of Clostridium tetani infection.
Brook I
Expert Rev Anti Infect Ther 2008 Jun;6(3):327-36. doi: 10.1586/14787210.6.3.327. PMID: 18588497
Treatment of tetanus neonatorum with muscle relaxants and intermittent positive-pressure ventilation.
Smythe PM, Bowie MD, Voss TJ
Br Med J 1974 Feb 9;1(5901):223-6. doi: 10.1136/bmj.1.5901.223. PMID: 4131848Free PMC Article
Treatment of tetanus neonatorum.
Smythe PM
Int Anesthesiol Clin 1966 Summer;4(2):435-43. doi: 10.1097/00004311-196622000-00016. PMID: 5335337

Recent clinical studies

Etiology

Clinical features and outcomes of tetanus: Analysis using a National Inpatient Database in Japan.
Nakajima M, Aso S, Matsui H, Fushimi K, Yasunaga H
J Crit Care 2018 Apr;44:388-391. Epub 2017 Dec 29 doi: 10.1016/j.jcrc.2017.12.025. PMID: 29304489
Fractures of the acromion in tetanus neonatorum [corrected].
Kalideen JM, Satyapal KS
Clin Radiol 1994 Aug;49(8):563-5. doi: 10.1016/s0009-9260(05)82938-1. PMID: 7955871
Tetanus in Israel, Judea/Samaria and Gaza, 1968-89: progress and challenge.
Tulchinsky TH, Friedman JB, Acker C, Ben David A, Slater PE
Isr J Med Sci 1990 Aug;26(8):438-42. PMID: 2401606
Trial of pyridoxine therapy for tetanus neonatorum.
Godel JC
J Infect Dis 1982 Apr;145(4):547-9. doi: 10.1093/infdis/145.4.547. PMID: 7069234
Use of tetanus toxoid for the prevention of neonatal tetanus. 1. Reduction of neonatal mortality by immunization of non-pregnant and pregnant women in rural Bangladesh.
Rahman M, Chen LC, Chakraborty J, Yunus M, Chowdhury AI, Sarder AM, Bhatia S, Curlin GT
Bull World Health Organ 1982;60(2):261-7. PMID: 6980736Free PMC Article

Diagnosis

Clinical features and outcomes of tetanus: Analysis using a National Inpatient Database in Japan.
Nakajima M, Aso S, Matsui H, Fushimi K, Yasunaga H
J Crit Care 2018 Apr;44:388-391. Epub 2017 Dec 29 doi: 10.1016/j.jcrc.2017.12.025. PMID: 29304489
The influence of pyridoxin in the treatment of tetanus neonatorum.
Dianto, Mustadjab I
Paediatr Indones 1991 May-Jun;31(5-6):165-9. PMID: 1896198
Botulism and tetanus: selected epidemiologic and microbiologic aspects.
Dowell VR Jr
Rev Infect Dis 1984 Mar-Apr;6 Suppl 1:S202-7. doi: 10.1093/clinids/6.supplement_1.s202. PMID: 6372030
The umbilical cord: care, anomalies, and diseases.
Elhassani SB
South Med J 1984 Jun;77(6):730-6. doi: 10.1097/00007611-198406000-00017. PMID: 6233703
Reduction of infant mortality in India.
Kumar V, Datta N
Indian J Pediatr 1982 Nov-Dec;49(401):777-80. doi: 10.1007/BF02976966. PMID: 7182351

Therapy

Current concepts in the management of Clostridium tetani infection.
Brook I
Expert Rev Anti Infect Ther 2008 Jun;6(3):327-36. doi: 10.1586/14787210.6.3.327. PMID: 18588497
Pyridoxine therapy in tetanus neonatorum.
Hajailay R, Sharan R, Agarwal VK, Srivastava AK
Indian Pediatr 1983 Dec;20(12):935-9. PMID: 6676307
Trial of pyridoxine therapy for tetanus neonatorum.
Godel JC
J Infect Dis 1982 Apr;145(4):547-9. doi: 10.1093/infdis/145.4.547. PMID: 7069234
Use of tetanus toxoid for the prevention of neonatal tetanus. 1. Reduction of neonatal mortality by immunization of non-pregnant and pregnant women in rural Bangladesh.
Rahman M, Chen LC, Chakraborty J, Yunus M, Chowdhury AI, Sarder AM, Bhatia S, Curlin GT
Bull World Health Organ 1982;60(2):261-7. PMID: 6980736Free PMC Article
Treatment of tetanus neonatorum with muscle relaxants and intermittent positive-pressure ventilation.
Smythe PM, Bowie MD, Voss TJ
Br Med J 1974 Feb 9;1(5901):223-6. doi: 10.1136/bmj.1.5901.223. PMID: 4131848Free PMC Article

Prognosis

Clinical features and outcomes of tetanus: Analysis using a National Inpatient Database in Japan.
Nakajima M, Aso S, Matsui H, Fushimi K, Yasunaga H
J Crit Care 2018 Apr;44:388-391. Epub 2017 Dec 29 doi: 10.1016/j.jcrc.2017.12.025. PMID: 29304489
Tetanus in Israel, Judea/Samaria and Gaza, 1968-89: progress and challenge.
Tulchinsky TH, Friedman JB, Acker C, Ben David A, Slater PE
Isr J Med Sci 1990 Aug;26(8):438-42. PMID: 2401606
Role of intrathecal tetanus antitoxin (equine) in tetanus neonatorum.
Singh G, Goyal BB, Singh DP
J Indian Med Assoc 1989 Jan;87(1):8-10. PMID: 2754273
Trial of pyridoxine therapy for tetanus neonatorum.
Godel JC
J Infect Dis 1982 Apr;145(4):547-9. doi: 10.1093/infdis/145.4.547. PMID: 7069234
Tetanus neonatorum--clinical manifestations.
Athavale VB
J Pediatr 1965 Oct;67(4):649-57. doi: 10.1016/s0022-3476(65)80438-3. PMID: 5832559

Clinical prediction guides

P.A. Schleisner: a pioneer in epidemiology.
Olafsson O
J Clin Epidemiol 1999 Oct;52(10):905-7. doi: 10.1016/s0895-4356(99)00096-7. PMID: 10513751
Determinants of neonatal mortality in central Sudan.
Taha TE, Gray RH, Abdelwahab MM
Ann Trop Paediatr 1993;13(4):359-64. doi: 10.1080/02724936.1993.11747671. PMID: 7506883
Pyridoxine in the treatment of tetanus neonatorum.
Caglar MK
Paediatr Indones 1989 Nov-Dec;29(11-12):233-6. PMID: 2488239
Mechanical ventilation in newborn infants.
Kishan J, Valdez ME, Mir NA, Elzouki AY
Afr J Med Med Sci 1988 Jun;17(2):83-8. PMID: 2843022

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