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Metastatic Malignant Neoplasm in the Penis

MedGen UID:
577758
•Concept ID:
C0347002
•
Neoplastic Process
Synonyms: Metastasis to penis; Metastatic malignant neoplasm of penis; Metastatic malignant neoplasm to penis; Metastatic tumor to penis; Secondary malignant neoplasm of penis
SNOMED CT: Metastatic tumor to penis (94481001); Metastasis to penis (94481001); Secondary malignant neoplasm of penis (94481001); Metastatic malignant neoplasm to penis (94481001); Metastatic malignant neoplasm of penis (94481001)

Definition

The spread of a malignant neoplasm to the penis from an adjacent or distant anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Penis

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Contemporary Role of Radiotherapy in the Management of Primary Penile Tumors and Metastatic Disease.
Crook J
Urol Clin North Am 2016 Nov;43(4):435-448. doi: 10.1016/j.ucl.2016.06.005. PMID: 27717430
Advances in the treatment of carcinoma of the penis.
McDougal WS
Urology 2005 Nov;66(5 Suppl):114-7. doi: 10.1016/j.urology.2005.06.007. PMID: 16194717

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Use of flaps in inguinal lymphadenectomy in metastatic penile cancer.
Azevedo RA, Roxo AC, Alvares SHB, Baptista DP, Favorito LA
Int Braz J Urol 2021 Nov-Dec;47(6):1108-1119. doi: 10.1590/S1677-5538.IBJU.2021.99.14. PMID: 34115457Free PMC Article
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Natural history and epidemiology of HPV infection and cervical cancer.
Castellsagué X
Gynecol Oncol 2008 Sep;110(3 Suppl 2):S4-7. doi: 10.1016/j.ygyno.2008.07.045. PMID: 18760711
Inguinal node metastases.
Zaren HA, Copeland EM 3rd
Cancer 1978 Mar;41(3):919-23. doi: 10.1002/1097-0142(197803)41:3<919::aid-cncr2820410320>3.0.co;2-a. PMID: 638977

Diagnosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Malignant Priapism - What Do We Know About It?
Marcu D, Iorga L, Mischianu D, Bacalbasa N, Balescu I, Bratu O
In Vivo 2020 Sep-Oct;34(5):2225-2232. doi: 10.21873/invivo.12033. PMID: 32871745Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Urologic Complications Following Pelvic Radiotherapy.
Lobo N, Kulkarni M, Hughes S, Nair R, Khan MS, Thurairaja R
Urology 2018 Dec;122:1-9. Epub 2018 Jul 20 doi: 10.1016/j.urology.2018.07.017. PMID: 30036617
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600

Therapy

Current management and future perspectives of penile cancer: An updated review.
Peyraud F, Allenet C, Gross-Goupil M, Domblides C, Lefort F, Daste A, Yacoub M, Haaser T, Ferretti L, Robert G, Ravaud A
Cancer Treat Rev 2020 Nov;90:102087. Epub 2020 Aug 7 doi: 10.1016/j.ctrv.2020.102087. PMID: 32799062
An update on systemic therapy for penile cancer.
Resch I, Abufaraj M, Hübner NA, Shariat SF
Curr Opin Urol 2020 Mar;30(2):229-233. doi: 10.1097/MOU.0000000000000733. PMID: 31972637
Penile rehabilitation after pelvic cancer surgery.
Aoun F, Peltier A, van Velthoven R
ScientificWorldJournal 2015;2015:876046. Epub 2015 Feb 15 doi: 10.1155/2015/876046. PMID: 25785286Free PMC Article
HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600

Prognosis

Penile cancer in Ireland - A national review.
Anderson S, Breen KJ, Davis NF, Deady S, Sweeney P
Surgeon 2022 Jun;20(3):187-193. Epub 2021 May 24 doi: 10.1016/j.surge.2021.04.004. PMID: 34034967
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Malignant Priapism - What Do We Know About It?
Marcu D, Iorga L, Mischianu D, Bacalbasa N, Balescu I, Bratu O
In Vivo 2020 Sep-Oct;34(5):2225-2232. doi: 10.21873/invivo.12033. PMID: 32871745Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Inguinal node metastases.
Zaren HA, Copeland EM 3rd
Cancer 1978 Mar;41(3):919-23. doi: 10.1002/1097-0142(197803)41:3<919::aid-cncr2820410320>3.0.co;2-a. PMID: 638977

Clinical prediction guides

Clinical Profile and Predictors of Survival in Carcinoma Penis Patients.
Garg V, Ray M, Haresh KP, Sahoo RK, Sharma A, Kaushal S, Batra A
Curr Oncol 2023 Apr 28;30(5):4563-4574. doi: 10.3390/curroncol30050345. PMID: 37232803Free PMC Article
Current management and future perspectives of penile cancer: An updated review.
Peyraud F, Allenet C, Gross-Goupil M, Domblides C, Lefort F, Daste A, Yacoub M, Haaser T, Ferretti L, Robert G, Ravaud A
Cancer Treat Rev 2020 Nov;90:102087. Epub 2020 Aug 7 doi: 10.1016/j.ctrv.2020.102087. PMID: 32799062
An update on systemic therapy for penile cancer.
Resch I, Abufaraj M, Hübner NA, Shariat SF
Curr Opin Urol 2020 Mar;30(2):229-233. doi: 10.1097/MOU.0000000000000733. PMID: 31972637
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Contemporary Role of Radiotherapy in the Management of Primary Penile Tumors and Metastatic Disease.
Crook J
Urol Clin North Am 2016 Nov;43(4):435-448. doi: 10.1016/j.ucl.2016.06.005. PMID: 27717430

Recent systematic reviews

Does bipolar energy provide any advantage over monopolar surgery in transurethral resection of non-muscle invasive bladder tumors? A systematic review and meta-analysis.
Tzelves L, Mourmouris P, Skolarikos A
World J Urol 2021 Apr;39(4):1093-1105. Epub 2020 Jun 26 doi: 10.1007/s00345-020-03313-w. PMID: 32591900
Penile Cancer: Contemporary Lymph Node Management.
O'Brien JS, Perera M, Manning T, Bozin M, Cabarkapa S, Chen E, Lawrentschuk N
J Urol 2017 Jun;197(6):1387-1395. Epub 2017 Jan 20 doi: 10.1016/j.juro.2017.01.059. PMID: 28115191
The Use of Unidirectional Barbed Suture for Urethrovesical Anastomosis during Robot-Assisted Radical Prostatectomy: A Systematic Review and Meta-Analysis of Efficacy and Safety.
Li H, Liu C, Zhang H, Xu W, Liu J, Chen Y, Li T, Li B, Wu Z, Xia T
PLoS One 2015;10(7):e0131167. Epub 2015 Jul 2 doi: 10.1371/journal.pone.0131167. PMID: 26135310Free PMC Article
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Accuracy of 18F-FDG PET/CT for diagnosing inguinal lymph node involvement in penile squamous cell carcinoma: systematic review and meta-analysis of the literature.
Sadeghi R, Gholami H, Zakavi SR, Kakhki VR, Horenblas S
Clin Nucl Med 2012 May;37(5):436-41. doi: 10.1097/RLU.0b013e318238f6ea. PMID: 22475891

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