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Overlap syndrome

MedGen UID:
592755
•Concept ID:
C0410000
•
Disease or Syndrome
Synonym: Overlap Syndrome
SNOMED CT: Overlap syndrome (276657008)

Definition

An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOverlap syndrome

Professional guidelines

PubMed

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article

Recent clinical studies

Etiology

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Antimitochondrial Antibodies: from Bench to Bedside.
Colapietro F, Lleo A, Generali E
Clin Rev Allergy Immunol 2022 Oct;63(2):166-177. Epub 2021 Sep 29 doi: 10.1007/s12016-021-08904-y. PMID: 34586589Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
Overlap Syndromes.
Chazouillères O
Dig Dis 2015;33 Suppl 2:181-7. Epub 2015 Dec 7 doi: 10.1159/000440831. PMID: 26641819

Diagnosis

Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Asthma in the Elderly.
Braman SS
Clin Geriatr Med 2017 Nov;33(4):523-537. Epub 2017 Jul 29 doi: 10.1016/j.cger.2017.06.005. PMID: 28991648
Asthma-COPD overlap syndrome and precision medicine.
Bovornkitti S
Asian Pac J Allergy Immunol 2017 Mar;35(1):1-2. PMID: 28431471
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
COPD-bronchiectasis overlap syndrome.
Hurst JR, Elborn JS, De Soyza A; BRONCH-UK Consortium
Eur Respir J 2015 Feb;45(2):310-3. doi: 10.1183/09031936.00170014. PMID: 25653262

Therapy

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease.
Lee JY, Cevallos SA, Byndloss MX, Tiffany CR, Olsan EE, Butler BP, Young BM, Rogers AWL, Nguyen H, Kim K, Choi SW, Bae E, Lee JH, Min UG, Lee DC, Bäumler AJ
Cell Host Microbe 2020 Aug 12;28(2):273-284.e6. Epub 2020 Jul 14 doi: 10.1016/j.chom.2020.06.001. PMID: 32668218Free PMC Article
Rheumatologic Diseases and the Liver.
Gebreselassie A, Aduli F, Howell CD
Clin Liver Dis 2019 May;23(2):247-261. Epub 2019 Mar 8 doi: 10.1016/j.cld.2018.12.007. PMID: 30947875
Overlap Syndromes.
Chazouillères O
Dig Dis 2015;33 Suppl 2:181-7. Epub 2015 Dec 7 doi: 10.1159/000440831. PMID: 26641819
Relapsing polychondritis.
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963

Prognosis

Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article
COPD-bronchiectasis overlap syndrome.
Hurst JR, Elborn JS, De Soyza A; BRONCH-UK Consortium
Eur Respir J 2015 Feb;45(2):310-3. doi: 10.1183/09031936.00170014. PMID: 25653262
Relapsing polychondritis.
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963
Scleroderma overlap syndrome.
Balbir-Gurman A, Braun-Moscovici Y
Isr Med Assoc J 2011 Jan;13(1):14-20. PMID: 21446230

Clinical prediction guides

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Genetic complexity of chronic myelomonocytic leukemia.
Patel AB, Deininger MW
Leuk Lymphoma 2021 May;62(5):1031-1045. Epub 2020 Dec 18 doi: 10.1080/10428194.2020.1856837. PMID: 33337259
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995

Recent systematic reviews

Prevalence and impact of Sjögren's syndrome in primary biliary cholangitis: a systematic review and meta-analysis.
Deng X, Li J, Hou S, Ci B, Liu B, Xu K
Ann Hepatol 2022 Nov-Dec;27(6):100746. Epub 2022 Aug 13 doi: 10.1016/j.aohep.2022.100746. PMID: 35970319
Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis.
Shah AJ, Quek E, Alqahtani JS, Hurst JR, Mandal S
Sleep Med Rev 2022 Jun;63:101627. Epub 2022 Mar 22 doi: 10.1016/j.smrv.2022.101627. PMID: 35413500
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis.
Alshabanat A, Zafari Z, Albanyan O, Dairi M, FitzGerald JM
PLoS One 2015;10(9):e0136065. Epub 2015 Sep 3 doi: 10.1371/journal.pone.0136065. PMID: 26336076Free PMC Article

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