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Intraventricular Hemorrhage of the Newborn without Ventricular Dilatation

MedGen UID:
634836
•Concept ID:
C0475590
•
Disease or Syndrome
Synonym: Grade 2 Intraventricular Hemorrhage of the Newborn

Definition

Bleeding into the lateral cerebral ventricles of a newborn infant without acute ventricular dilatation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraventricular Hemorrhage of the Newborn without Ventricular Dilatation

Professional guidelines

PubMed

Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage.
Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, Uysal G, Tas M, Musa K
Childs Nerv Syst 2014 Mar;30(3):411-8. Epub 2013 Aug 2 doi: 10.1007/s00381-013-2243-0. PMID: 23907139
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K
Arch Dis Child Fetal Neonatal Ed 2012 May;97(3):F229-3. Epub 2011 Feb 2 doi: 10.1136/adc.2010.190173. PMID: 21289015

Recent clinical studies

Etiology

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
State-of-the-art neonatal cerebral ultrasound: technique and reporting.
Dudink J, Jeanne Steggerda S, Horsch S; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):3-12. doi: 10.1038/s41390-020-0776-y. PMID: 32218539Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Preterm brain injury: Germinal matrix-intraventricular hemorrhage and post-hemorrhagic ventricular dilatation.
Leijser LM, de Vries LS
Handb Clin Neurol 2019;162:173-199. doi: 10.1016/B978-0-444-64029-1.00008-4. PMID: 31324310
Prospective multicenter studies in pediatric hydrocephalus.
Kestle JRW, Riva-Cambrin J
J Neurosurg Pediatr 2019 Feb 1;23(2):135-141. doi: 10.3171/2018.10.PEDS18328. PMID: 30717034

Diagnosis

Intraventricular haemorrhage and posthaemorrhagic ventricular dilatation: moving beyond CSF diversion.
Chari A, Mallucci C, Whitelaw A, Aquilina K
Childs Nerv Syst 2021 Nov;37(11):3375-3383. Epub 2021 May 15 doi: 10.1007/s00381-021-05206-8. PMID: 33993367Free PMC Article
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
Intraventricular Hemorrhage and Posthemorrhagic Ventricular Dilation: Current Approaches to Improve Outcomes.
Wilson D, Kim D, Breibart S
Neonatal Netw 2020 May 1;39(3):158-169. doi: 10.1891/0730-0832.39.3.158. PMID: 32457190
Periventricular-intraventricular hemorrhage.
Allan WC, Volpe JJ
Pediatr Clin North Am 1986 Feb;33(1):47-63. doi: 10.1016/s0031-3955(16)34969-0. PMID: 3513102

Therapy

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
Prospective multicenter studies in pediatric hydrocephalus.
Kestle JRW, Riva-Cambrin J
J Neurosurg Pediatr 2019 Feb 1;23(2):135-141. doi: 10.3171/2018.10.PEDS18328. PMID: 30717034
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K
Arch Dis Child Fetal Neonatal Ed 2012 May;97(3):F229-3. Epub 2011 Feb 2 doi: 10.1136/adc.2010.190173. PMID: 21289015
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A, Odd DE
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD000498. doi: 10.1002/14651858.CD000498.pub2. PMID: 17943743Free PMC Article

Prognosis

Cerebral gray matter injuries in infants with intraventricular hemorrhage.
Sharma DR, Agyemang A, Ballabh P
Semin Perinatol 2022 Aug;46(5):151595. Epub 2022 Mar 12 doi: 10.1016/j.semperi.2022.151595. PMID: 35418320Free PMC Article
Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Prospective multicenter studies in pediatric hydrocephalus.
Kestle JRW, Riva-Cambrin J
J Neurosurg Pediatr 2019 Feb 1;23(2):135-141. doi: 10.3171/2018.10.PEDS18328. PMID: 30717034
Early and late complications of germinal matrix-intraventricular haemorrhage in the preterm infant: what is new?
Brouwer AJ, Groenendaal F, Benders MJ, de Vries LS
Neonatology 2014;106(4):296-303. Epub 2014 Aug 20 doi: 10.1159/000365127. PMID: 25171657

Clinical prediction guides

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Cerebral gray matter injuries in infants with intraventricular hemorrhage.
Sharma DR, Agyemang A, Ballabh P
Semin Perinatol 2022 Aug;46(5):151595. Epub 2022 Mar 12 doi: 10.1016/j.semperi.2022.151595. PMID: 35418320Free PMC Article
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
State-of-the-art neonatal cerebral ultrasound: technique and reporting.
Dudink J, Jeanne Steggerda S, Horsch S; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):3-12. doi: 10.1038/s41390-020-0776-y. PMID: 32218539Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article

Recent systematic reviews

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A, Odd DE
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD000498. doi: 10.1002/14651858.CD000498.pub2. PMID: 17943743Free PMC Article
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A
Cochrane Database Syst Rev 2001;(1):CD000498. doi: 10.1002/14651858.CD000498. PMID: 11279695
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A
Cochrane Database Syst Rev 2000;(2):CD000498. doi: 10.1002/14651858.CD000498. PMID: 10796211

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