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Giant cell tumor of bone

MedGen UID:
64624
•Concept ID:
C0206638
•
Neoplastic Process
Synonym: Giant Cell Tumor of Bone
SNOMED CT: Giant cell tumor of bone (697970009); GTCT - Giant cell tumor of bone (697970009); Giant cell tumor of bone (57500000); Osteoclastoma (57500000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011847
Monarch Initiative: MONDO:0005674
Orphanet: ORPHA363976

Definition

A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell tumor of bone

Professional guidelines

PubMed

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Current management of giant-cell tumor of bone in the denosumab era.
Nagano A, Urakawa H, Tanaka K, Ozaki T
Jpn J Clin Oncol 2022 May 5;52(5):411-416. doi: 10.1093/jjco/hyac018. PMID: 35199172
The multidisciplinary management of giant cell tumor of bone.
Ng VY, Davidson DJ, Kim EY, Pollack SM, Conrad Iii EU, Jones RL
Expert Rev Anticancer Ther 2014 Jul;14(7):783-90. Epub 2014 Mar 26 doi: 10.1586/14737140.2014.901891. PMID: 24666240

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

Recent clinical studies

Etiology

Multicentric Giant Cell Tumor of Bone.
Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024
Giant cell tumor of bone.
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193

Diagnosis

Multicentric Giant Cell Tumor of Bone.
Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Calcaneal Bone Tumors.
Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653
The two faces of giant cell tumor of bone.
Scotto di Carlo F, Whyte MP, Gianfrancesco F
Cancer Lett 2020 Oct 1;489:1-8. Epub 2020 Jun 2 doi: 10.1016/j.canlet.2020.05.031. PMID: 32502498
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375
Giant-cell tumor.
Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

Therapy

Narlumosbart: First Approval.
Dhillon S
Drugs 2024 Jan;84(1):105-109. doi: 10.1007/s40265-023-01985-3. PMID: 38112898
Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Current management of giant-cell tumor of bone in the denosumab era.
Nagano A, Urakawa H, Tanaka K, Ozaki T
Jpn J Clin Oncol 2022 May 5;52(5):411-416. doi: 10.1093/jjco/hyac018. PMID: 35199172
Giant Cell Tumor of Bone: An Update.
Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215

Prognosis

Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis.
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375
Giant-cell tumor.
Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

Clinical prediction guides

Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Giant cell tumor of bone in an eighteenth-century Italian mummy.
Ventura L, Petrella E, Piciucchi S, Cilli E, Luiselli D, Feeney RNM, Traversari M
Virchows Arch 2021 Dec;479(6):1255-1261. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03192-5. PMID: 34462806Free PMC Article
Giant cell tumor of bone: current treatment options.
Skubitz KM
Curr Treat Options Oncol 2014 Sep;15(3):507-18. doi: 10.1007/s11864-014-0289-1. PMID: 24788576

Recent systematic reviews

Association between preoperative denosumab and the risk of local recurrence in patients with giant cell tumor of bone: A meta-analysis and systematic review.
Sun Z, Wu Z, Zhang L, Jia Q, Zhou Z, Xiao J
J Cancer Res Ther 2023 Feb;19(1):25-33. doi: 10.4103/jcrt.jcrt_1171_22. PMID: 37006039
The giant cell tumor during pregnancy: A review of literature.
Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835
Metastasectomy Versus Non-Metastasectomy for Giant Cell Tumor of Bone Lung Metastases.
Tsukamoto S, Mavrogenis AF, Tanaka Y, Kido A, Honoki K, Tanaka Y, Errani C
Orthopedics 2021 Nov-Dec;44(6):e707-e712. Epub 2021 Oct 1 doi: 10.3928/01477447-20211001-01. PMID: 34618641
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis.
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Giant cell tumor of the pelvis: a systematic review.
Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989Free PMC Article

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

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