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Diastolic hypertension

MedGen UID:
65901
•Concept ID:
C0235222
•
Disease or Syndrome
Synonym: Diastolic Hypertension
SNOMED CT: Diastolic hypertension (48146000)

Definition

Hypertension characterized diastolic blood pressure greater than 90 mmHg on two occasions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiastolic hypertension

Professional guidelines

PubMed

Prevalence, awareness, and treatment of isolated diastolic hypertension in the United States.
Zhang X, Wang X, Wang M, Qu H, Hu B, Li Q
Eur J Intern Med 2023 Jun;112:93-99. Epub 2023 Mar 29 doi: 10.1016/j.ejim.2023.03.026. PMID: 37002149
New findings bearing on the prevention, detection and management of high blood pressure.
Carey RM, Whelton PK
Curr Opin Cardiol 2021 Jul 1;36(4):429-435. doi: 10.1097/HCO.0000000000000864. PMID: 34059611Free PMC Article
Management of Hypertension in the Elderly and Frail Elderly.
Ferri C, Ferri L, Desideri G
High Blood Press Cardiovasc Prev 2017 Mar;24(1):1-11. Epub 2017 Feb 8 doi: 10.1007/s40292-017-0185-4. PMID: 28181201

Recent clinical studies

Etiology

Is Isolated Diastolic Hypertension an Important Phenotype?
Romero CA, Tabares AH, Orias M
Curr Cardiol Rep 2021 Oct 16;23(12):177. doi: 10.1007/s11886-021-01609-w. PMID: 34657205Free PMC Article
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.
Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL
N Engl J Med 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180. PMID: 31314968
ACOG Committee Opinion No. 767: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period.
Obstet Gynecol 2019 Feb;133(2):e174-e180. doi: 10.1097/AOG.0000000000003075. PMID: 30575639
Thyroid Hormone and Vascular Remodeling.
Ichiki T
J Atheroscler Thromb 2016;23(3):266-75. Epub 2015 Nov 11 doi: 10.5551/jat.32755. PMID: 26558400
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Diagnosis

Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Isolated diastolic hypertension is not associated with endothelial dysfunction.
Han Y, Maruhashi T, Kajikawa M, Kishimoto S, Yamaji T, Harada T, Hashimoto Y, Yusoff FM, Nakano Y, Chayama K, Nakashima A, Goto C, Yoshimura K, Higashi Y
Hypertens Res 2022 Apr;45(4):698-707. Epub 2022 Feb 3 doi: 10.1038/s41440-022-00854-y. PMID: 35115698
Prevalence of hypertension and hypertension phenotypes after three visits in Chinese urban children.
Dong J, Dong H, Yan Y, Cheng H, Zhao X, Mi J; on behalf of the China Child, Adolescent Cardiovascular Health (CCACH) collaboration members
J Hypertens 2022 Jul 1;40(7):1270-1277. doi: 10.1097/HJH.0000000000002977. PMID: 34285150
Underdiagnosis of Isolated Systolic and Isolated Diastolic Hypertension.
Conell C, Flint AC, Ren X, Banki NM, Chan SL, Rao VA, Edwards NJ, Melles RB, Bhatt DL
Am J Cardiol 2021 Feb 15;141:56-61. Epub 2020 Dec 5 doi: 10.1016/j.amjcard.2020.11.020. PMID: 33285092
Management of Hypertension in the Elderly and Frail Elderly.
Ferri C, Ferri L, Desideri G
High Blood Press Cardiovasc Prev 2017 Mar;24(1):1-11. Epub 2017 Feb 8 doi: 10.1007/s40292-017-0185-4. PMID: 28181201

Therapy

Isolated diastolic hypertension is not associated with endothelial dysfunction.
Han Y, Maruhashi T, Kajikawa M, Kishimoto S, Yamaji T, Harada T, Hashimoto Y, Yusoff FM, Nakano Y, Chayama K, Nakashima A, Goto C, Yoshimura K, Higashi Y
Hypertens Res 2022 Apr;45(4):698-707. Epub 2022 Feb 3 doi: 10.1038/s41440-022-00854-y. PMID: 35115698
ACOG Committee Opinion No. 767: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period.
Obstet Gynecol 2019 Feb;133(2):e174-e180. doi: 10.1097/AOG.0000000000003075. PMID: 30575639
Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial.
Azizi M, Schmieder RE, Mahfoud F, Weber MA, Daemen J, Davies J, Basile J, Kirtane AJ, Wang Y, Lobo MD, Saxena M, Feyz L, Rader F, Lurz P, Sayer J, Sapoval M, Levy T, Sanghvi K, Abraham J, Sharp ASP, Fisher NDL, Bloch MJ, Reeve-Stoffer H, Coleman L, Mullin C, Mauri L; RADIANCE-HTN Investigators
Lancet 2018 Jun 9;391(10137):2335-2345. Epub 2018 May 23 doi: 10.1016/S0140-6736(18)31082-1. PMID: 29803590
Hypothyroidism and hypertension.
Stabouli S, Papakatsika S, Kotsis V
Expert Rev Cardiovasc Ther 2010 Nov;8(11):1559-65. doi: 10.1586/erc.10.141. PMID: 21090931
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Prognosis

New Insights Into Cerebrovascular Pathophysiology and Hypertension.
Webb AJS, Werring DJ
Stroke 2022 Apr;53(4):1054-1064. Epub 2022 Mar 8 doi: 10.1161/STROKEAHA.121.035850. PMID: 35255709Free PMC Article
Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Is Isolated Diastolic Hypertension an Important Phenotype?
Romero CA, Tabares AH, Orias M
Curr Cardiol Rep 2021 Oct 16;23(12):177. doi: 10.1007/s11886-021-01609-w. PMID: 34657205Free PMC Article
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.
Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL
N Engl J Med 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180. PMID: 31314968
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Clinical prediction guides

Controversies in Hypertension IV: Renal Denervation.
Filippone EJ, Naccarelli GV, Foy AJ
Am J Med 2023 Sep;136(9):857-868. Epub 2023 May 23 doi: 10.1016/j.amjmed.2023.05.010. PMID: 37230403
New Insights Into Cerebrovascular Pathophysiology and Hypertension.
Webb AJS, Werring DJ
Stroke 2022 Apr;53(4):1054-1064. Epub 2022 Mar 8 doi: 10.1161/STROKEAHA.121.035850. PMID: 35255709Free PMC Article
Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.
Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL
N Engl J Med 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180. PMID: 31314968
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Recent systematic reviews

Midlife Hypertension and Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Lennon MJ, Makkar SR, Crawford JD, Sachdev PS
J Alzheimers Dis 2019;71(1):307-316. doi: 10.3233/JAD-190474. PMID: 31381518
Pharmacotherapy for hypertension in adults 60 years or older.
Musini VM, Tejani AM, Bassett K, Puil L, Wright JM
Cochrane Database Syst Rev 2019 Jun 5;6(6):CD000028. doi: 10.1002/14651858.CD000028.pub3. PMID: 31167038Free PMC Article
Automated blood pressure measurement in atrial fibrillation: a systematic review and meta-analysis.
Stergiou GS, Kollias A, Destounis A, Tzamouranis D
J Hypertens 2012 Nov;30(11):2074-82. doi: 10.1097/HJH.0b013e32835850d7. PMID: 22914573
The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis.
Power MC, Weuve J, Gagne JJ, McQueen MB, Viswanathan A, Blacker D
Epidemiology 2011 Sep;22(5):646-59. doi: 10.1097/EDE.0b013e31822708b5. PMID: 21705906Free PMC Article
Pharmacotherapy for hypertension in the elderly.
Musini VM, Tejani AM, Bassett K, Wright JM
Cochrane Database Syst Rev 2009 Oct 7;(4):CD000028. doi: 10.1002/14651858.CD000028.pub2. PMID: 19821263

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