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High risk pregnancy

MedGen UID:
66982
•Concept ID:
C0242786
•
Pathologic Function
Synonyms: High Risk Pregnancy; High-Risk Pregnancies; High-Risk Pregnancy; Pregnancies, High-Risk; Pregnancy, High Risk; Pregnancy, High-Risk
SNOMED CT: HRP - High risk pregnancy (47200007); High risk pregnancy (47200007)

Definition

A fetal/maternal condition that is risky and portends complications for the mother and/or fetus, when compared to a normal pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh risk pregnancy

Professional guidelines

PubMed

Pharmacological treatment of bipolar disorder in pregnancy: An update on safety considerations.
Singh S, Deep R
Indian J Pharmacol 2022 Nov-Dec;54(6):443-451. doi: 10.4103/ijp.ijp_407_21. PMID: 36722556Free PMC Article
Diagnostic protocols for the management of pregnancy of unknown location: a systematic review and meta-analysis.
Bobdiwala S, Saso S, Verbakel JY, Al-Memar M, Van Calster B, Timmerman D, Bourne T
BJOG 2019 Jan;126(2):190-198. Epub 2018 Sep 20 doi: 10.1111/1471-0528.15442. PMID: 30129999
Management of high-risk pregnancy.
Coco L, Giannone TT, Zarbo G
Minerva Ginecol 2014 Aug;66(4):383-9. PMID: 25020057

Recent clinical studies

Etiology

Fatherhood and high-risk pregnancy: a scoping review.
Jackson K, Erasmus E, Mabanga N
BMC Pregnancy Childbirth 2023 Mar 16;23(1):168. doi: 10.1186/s12884-023-05422-x. PMID: 36922778Free PMC Article
Pharmacological treatment of bipolar disorder in pregnancy: An update on safety considerations.
Singh S, Deep R
Indian J Pharmacol 2022 Nov-Dec;54(6):443-451. doi: 10.4103/ijp.ijp_407_21. PMID: 36722556Free PMC Article
High-Risk Pregnancy.
Holness N
Nurs Clin North Am 2018 Jun;53(2):241-251. Epub 2018 Apr 7 doi: 10.1016/j.cnur.2018.01.010. PMID: 29779516
Predictive factors for intrauterine growth restriction.
Albu AR, Anca AF, Horhoianu VV, Horhoianu IA
J Med Life 2014 Jun 15;7(2):165-71. Epub 2014 Jun 25 PMID: 25408721Free PMC Article
Management of high-risk pregnancy.
Coco L, Giannone TT, Zarbo G
Minerva Ginecol 2014 Aug;66(4):383-9. PMID: 25020057

Diagnosis

Discordance in twins: Association versus prediction.
Cerra C, D'Antonio F
Best Pract Res Clin Obstet Gynaecol 2022 Nov;84:33-42. Epub 2022 Aug 23 doi: 10.1016/j.bpobgyn.2022.08.001. PMID: 36182539
Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Sleep Disorders in Pregnancy.
Bazalakova M
Semin Neurol 2017 Dec;37(6):661-668. Epub 2017 Dec 21 doi: 10.1055/s-0037-1608843. PMID: 29270939
Maternal super-obesity.
Hartge D, Spiegler J, Schroeer A, Deckwart V, Weichert J
Arch Gynecol Obstet 2016 May;293(5):987-92. Epub 2015 Oct 23 doi: 10.1007/s00404-015-3921-9. PMID: 26498605
Predictive factors for intrauterine growth restriction.
Albu AR, Anca AF, Horhoianu VV, Horhoianu IA
J Med Life 2014 Jun 15;7(2):165-71. Epub 2014 Jun 25 PMID: 25408721Free PMC Article

Therapy

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.
Capone V, Persico N, Berrettini A, Decramer S, De Marco EA, De Palma D, Familiari A, Feitz W, Herthelius M, Kazlauskas V, Liebau M, Manzoni G, Maternik M, Mosiello G, Schanstra JP, Vande Walle J, Wühl E, Ylinen E, Zurowska A, Schaefer F, Montini G
Nat Rev Urol 2022 May;19(5):295-303. Epub 2022 Feb 8 doi: 10.1038/s41585-022-00563-8. PMID: 35136187
Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials.
EPPPIC Group
Lancet 2021 Mar 27;397(10280):1183-1194. doi: 10.1016/S0140-6736(21)00217-8. PMID: 33773630
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200

Prognosis

Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.
Capone V, Persico N, Berrettini A, Decramer S, De Marco EA, De Palma D, Familiari A, Feitz W, Herthelius M, Kazlauskas V, Liebau M, Manzoni G, Maternik M, Mosiello G, Schanstra JP, Vande Walle J, Wühl E, Ylinen E, Zurowska A, Schaefer F, Montini G
Nat Rev Urol 2022 May;19(5):295-303. Epub 2022 Feb 8 doi: 10.1038/s41585-022-00563-8. PMID: 35136187
Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes.
Del Vecchio G, Li Q, Li W, Thamotharan S, Tosevska A, Morselli M, Sung K, Janzen C, Zhou X, Pellegrini M, Devaskar SU
Epigenetics 2021 Jun;16(6):642-661. Epub 2020 Oct 13 doi: 10.1080/15592294.2020.1816774. PMID: 33045922Free PMC Article
Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Predictive factors for intrauterine growth restriction.
Albu AR, Anca AF, Horhoianu VV, Horhoianu IA
J Med Life 2014 Jun 15;7(2):165-71. Epub 2014 Jun 25 PMID: 25408721Free PMC Article
Management of high-risk pregnancy.
Coco L, Giannone TT, Zarbo G
Minerva Ginecol 2014 Aug;66(4):383-9. PMID: 25020057

Clinical prediction guides

Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes.
Del Vecchio G, Li Q, Li W, Thamotharan S, Tosevska A, Morselli M, Sung K, Janzen C, Zhou X, Pellegrini M, Devaskar SU
Epigenetics 2021 Jun;16(6):642-661. Epub 2020 Oct 13 doi: 10.1080/15592294.2020.1816774. PMID: 33045922Free PMC Article
Effects of a Brief Electronic Mindfulness-Based Intervention on Relieving Prenatal Depression and Anxiety in Hospitalized High-Risk Pregnant Women: Exploratory Pilot Study.
Goetz M, Schiele C, Müller M, Matthies LM, Deutsch TM, Spano C, Graf J, Zipfel S, Bauer A, Brucker SY, Wallwiener M, Wallwiener S
J Med Internet Res 2020 Aug 11;22(8):e17593. doi: 10.2196/17593. PMID: 32780023Free PMC Article
Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Predictive factors for intrauterine growth restriction.
Albu AR, Anca AF, Horhoianu VV, Horhoianu IA
J Med Life 2014 Jun 15;7(2):165-71. Epub 2014 Jun 25 PMID: 25408721Free PMC Article

Recent systematic reviews

Placenta accreta spectrum disorders clinical practice guidelines: A systematic review.
Capannolo G, D'Amico A, Alameddine S, Di Girolamo R, Khalil A, Calì G, Trish IT, Coutinho CM, Herrera M, Liberati M, Lucidi A, Palacios-Jaraquemada J, Buca D, D'Antonio F
J Obstet Gynaecol Res 2023 May;49(5):1313-1321. Epub 2023 Feb 16 doi: 10.1111/jog.15544. PMID: 36796351
Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: A systematic review and network meta-analysis.
D'Antonio F, Berghella V, Di Mascio D, Saccone G, Sileo F, Flacco ME, Odibo AO, Liberati M, Manzoli L, Khalil A
Eur J Obstet Gynecol Reprod Biol 2021 Jun;261:166-177. Epub 2021 Apr 24 doi: 10.1016/j.ejogrb.2021.04.023. PMID: 33946019
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200

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