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Arsenical keratosis

MedGen UID:
678533
•Concept ID:
C0854707
•
Disease or Syndrome
Synonym: Arsenical Keratosis
SNOMED CT: Arsenical keratosis (403741004); Arsenical keratosis (788579001)

Definition

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVArsenical keratosis

Professional guidelines

PubMed

Arsenicosis: diagnosis and treatment.
Das NK, Sengupta SR
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):571-81. doi: 10.4103/0378-6323.45098. PMID: 19171979
Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal.
Guha Mazumder DN
J Environ Sci Health A Tox Hazard Subst Environ Eng 2003 Jan;38(1):141-63. doi: 10.1081/ese-120016886. PMID: 12635824
Skin carcinomas and treatment with photochemotherapy (PUVA).
Lindskov R
Acta Derm Venereol 1983;63(3):223-6. PMID: 6192635

Recent clinical studies

Etiology

Patient-Reported Outcomes of Arsenic-Related Skin Lesions in China.
Li Y, Jing D, Xiao Y, Huang X, Shen M
Biomed Res Int 2020;2020:6195975. Epub 2020 Sep 17 doi: 10.1155/2020/6195975. PMID: 33015173Free PMC Article
Role of linoleic acid in arsenical palmar keratosis.
Ahmed TS, Misbahuddin M
Int J Dermatol 2016 Mar;55(3):289-95. Epub 2015 Jul 31 doi: 10.1111/ijd.12831. PMID: 26235890
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Khandpur S, Sharma VK
J Dermatol 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x. PMID: 14684956
Merkel cell carcinoma, Bowen's disease and chronic occupational arsenic poisoning.
Tsuruta D, Hamada T, Mochida K, Nakagawa K, Kobayashi H, Ishii M
Br J Dermatol 1998 Aug;139(2):291-4. doi: 10.1046/j.1365-2133.1998.02369.x. PMID: 9767246

Diagnosis

Multiple minute digitate hyperkeratosis: a proposed algorithm for the digitate keratoses.
Caccetta TP, Dessauvagie B, McCallum D, Kumarasinghe SP
J Am Acad Dermatol 2012 Jul;67(1):e49-55. Epub 2010 Nov 3 doi: 10.1016/j.jaad.2010.07.023. PMID: 21050621
Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective.
Kessler GM, Ackerman AB
Am J Dermatopathol 2006 Dec;28(6):537-45. doi: 10.1097/01.dad.0000245196.73224.cb. PMID: 17122500
Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis?
Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen KH, Bieber T
Acta Derm Venereol 2000 Jul-Aug;80(4):292-3. doi: 10.1080/000155500750012207. PMID: 11028865
Merkel cell carcinoma, Bowen's disease and chronic occupational arsenic poisoning.
Tsuruta D, Hamada T, Mochida K, Nakagawa K, Kobayashi H, Ishii M
Br J Dermatol 1998 Aug;139(2):291-4. doi: 10.1046/j.1365-2133.1998.02369.x. PMID: 9767246

Therapy

Hematoporphyrin injection mediated photodynamic therapy for secondary squamous cell carcinoma of arsenical keratosis: A case report.
Fu T, Shen B, Liu X, Ma G, Li L, Feng H
Photodiagnosis Photodyn Ther 2024 Apr;46:104071. Epub 2024 Mar 28 doi: 10.1016/j.pdpdt.2024.104071. PMID: 38552815
Patient-Reported Outcomes of Arsenic-Related Skin Lesions in China.
Li Y, Jing D, Xiao Y, Huang X, Shen M
Biomed Res Int 2020;2020:6195975. Epub 2020 Sep 17 doi: 10.1155/2020/6195975. PMID: 33015173Free PMC Article
Defective beta1-integrins expression in arsenical keratosis and arsenic-treated cultured human keratinocytes.
Lee CH, Chen JS, Sun YL, Liao WT, Zheng YW, Chai CZ, Chen GS, Yu HS
J Cutan Pathol 2006 Feb;33(2):129-38. doi: 10.1111/j.0303-6987.2006.00361.x. PMID: 16420308
Pathology related to chronic arsenic exposure.
Centeno JA, Mullick FG, Martinez L, Page NP, Gibb H, Longfellow D, Thompson C, Ladich ER
Environ Health Perspect 2002 Oct;110 Suppl 5(Suppl 5):883-6. doi: 10.1289/ehp.02110s5883. PMID: 12426152Free PMC Article
Treatment of arsenical keratosis and Bowen's disease with acitretin.
Yerebakan O, Ermis O, Yilmaz E, Basaran E
Int J Dermatol 2002 Feb;41(2):84-7. doi: 10.1046/j.1365-4362.2002.01372.x. PMID: 11982642

Prognosis

Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Khandpur S, Sharma VK
J Dermatol 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x. PMID: 14684956

Clinical prediction guides

Arsenic Keratosis in a Patient from Newfoundland and Labrador, Canada: Case Report and Review.
Pratt M, Wadden P, Gulliver W
J Cutan Med Surg 2016 Jan;20(1):67-71. Epub 2015 Aug 3 doi: 10.1177/1203475415599342. PMID: 26239734
Treatment of arsenical keratosis and Bowen's disease with acitretin.
Yerebakan O, Ermis O, Yilmaz E, Basaran E
Int J Dermatol 2002 Feb;41(2):84-7. doi: 10.1046/j.1365-4362.2002.01372.x. PMID: 11982642
Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis?
Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen KH, Bieber T
Acta Derm Venereol 2000 Jul-Aug;80(4):292-3. doi: 10.1080/000155500750012207. PMID: 11028865
Electron microscopic observations of arsenical keratosis and Bowen's disease associated with chronic arsenicism.
Ohyama K, Sonoda K, Kuwahara H
Dermatologica 1982 Mar;164(3):161-6. doi: 10.1159/000250085. PMID: 7084538

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