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Critical illness myopathy

MedGen UID:: 685768
•Concept ID:: C1135188
•: Disease or Syndrome

Synonym:	Critical Illness Myopathy
SNOMED CT:	Critical illness myopathy (443819006)

Definition

Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCritical illness myopathy

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the musculature
    - Abnormal skeletal muscle morphology
      - Myopathy
        Critical illness myopathy

Professional guidelines

PubMed

Pathophysiology and management of critical illness polyneuropathy and myopathy.

Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888 Free PMC Article

An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults.

Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins RO, Hough CL, Kress JP, Latronico N, Moss M, Needham DM, Rich MM, Stevens RD, Wilson KC, Winkelman C, Zochodne DW, Ali NA; ATS Committee on ICU-acquired Weakness in Adults; American Thoracic Society
Am J Respir Crit Care Med 2014 Dec 15;190(12):1437-46. doi: 10.1164/rccm.201411-2011ST. PMID: 25496103

Treatment of critical illness polyneuropathy and/or myopathy - a systematic review.

Ydemann M, Eddelien HS, Lauritsen AØ
Dan Med J 2012 Oct;59(10):A4511. PMID: 23158890

See all (5)

Recent clinical studies

Etiology

Intensive care unit-acquired weakness: Questions the clinician should ask.

Tortuyaux R, Davion JB, Jourdain M
Rev Neurol (Paris) 2022 Jan-Feb;178(1-2):84-92. Epub 2022 Jan 5 doi: 10.1016/j.neurol.2021.12.007. PMID: 34998522

Pathophysiology and management of critical illness polyneuropathy and myopathy.

ICU-Acquired Weakness.

Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347 Free PMC Article

Clinical review: intensive care unit acquired weakness.

Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743 Free PMC Article

Physical rehabilitation for critical illness myopathy and neuropathy.

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049 Free PMC Article

See all (89)

Diagnosis

Intensive care unit-acquired weakness: Questions the clinician should ask.

Tortuyaux R, Davion JB, Jourdain M
Rev Neurol (Paris) 2022 Jan-Feb;178(1-2):84-92. Epub 2022 Jan 5 doi: 10.1016/j.neurol.2021.12.007. PMID: 34998522

Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge.

Merlonghi G, Antonini G, Garibaldi M
Autoimmun Rev 2022 Feb;21(2):102993. Epub 2021 Nov 16 doi: 10.1016/j.autrev.2021.102993. PMID: 34798316

Intensive care unit-acquired weakness: unanswered questions and targets for future research.

Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055 Free PMC Article

ICU-Acquired Weakness.

Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347 Free PMC Article

Clinical review: intensive care unit acquired weakness.

Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743 Free PMC Article

See all (116)

Therapy

What is in the Myopathy Literature?

Lacomis D
J Clin Neuromuscul Dis 2018 Jun;19(4):217-223. doi: 10.1097/CND.0000000000000203. PMID: 29794577

Physical rehabilitation for critical illness myopathy and neuropathy.

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049 Free PMC Article

ICU-acquired weakness.

Schweickert WD, Hall J
Chest 2007 May;131(5):1541-9. doi: 10.1378/chest.06-2065. PMID: 17494803

Critical illness myopathy and polyneuropathy.

Bird SJ, Rich MM
Curr Neurol Neurosci Rep 2002 Nov;2(6):527-33. doi: 10.1007/s11910-002-0041-2. PMID: 12359108

Critical illness myopathy.

Lacomis D, Zochodne DW, Bird SJ
Muscle Nerve 2000 Dec;23(12):1785-8. doi: 10.1002/1097-4598(200012)23:12<1785::aid-mus1>3.0.co;2-j. PMID: 11102901

See all (51)

Prognosis

Critical illness-associated weakness and related motor disorders.

Younger DS
Handb Clin Neurol 2023;195:707-777. doi: 10.1016/B978-0-323-98818-6.00031-5. PMID: 37562893

Intensive care unit-acquired weakness: Questions the clinician should ask.

Tortuyaux R, Davion JB, Jourdain M
Rev Neurol (Paris) 2022 Jan-Feb;178(1-2):84-92. Epub 2022 Jan 5 doi: 10.1016/j.neurol.2021.12.007. PMID: 34998522

Clinical review: intensive care unit acquired weakness.

Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743 Free PMC Article

Critical illness myopathy.

Latronico N, Tomelleri G, Filosto M
Curr Opin Rheumatol 2012 Nov;24(6):616-22. doi: 10.1097/BOR.0b013e3283588d2f. PMID: 22918529

Critical illness myopathy and neuropathy.

Latronico N, Guarneri B
Minerva Anestesiol 2008 Jun;74(6):319-23. PMID: 18500207

See all (61)

Clinical prediction guides

Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge.

Merlonghi G, Antonini G, Garibaldi M
Autoimmun Rev 2022 Feb;21(2):102993. Epub 2021 Nov 16 doi: 10.1016/j.autrev.2021.102993. PMID: 34798316

Pathophysiology and management of critical illness polyneuropathy and myopathy.

Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition.

Lad H, Saumur TM, Herridge MS, Dos Santos CC, Mathur S, Batt J, Gilbert PM
Int J Mol Sci 2020 Oct 22;21(21) doi: 10.3390/ijms21217840. PMID: 33105809 Free PMC Article

Intensive care unit-acquired weakness: unanswered questions and targets for future research.

Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055 Free PMC Article

Clinical review: intensive care unit acquired weakness.

Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743 Free PMC Article

See all (57)

Recent systematic reviews

Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis.

Price DR, Mikkelsen ME, Umscheid CA, Armstrong EJ
Crit Care Med 2016 Nov;44(11):2070-2078. doi: 10.1097/CCM.0000000000001839. PMID: 27513545

Physical rehabilitation for critical illness myopathy and neuropathy.

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049 Free PMC Article

Interventions for preventing critical illness polyneuropathy and critical illness myopathy.

Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G
Cochrane Database Syst Rev 2014 Jan 30;2014(1):CD006832. doi: 10.1002/14651858.CD006832.pub3. PMID: 24477672 Free PMC Article

Treatment of critical illness polyneuropathy and/or myopathy - a systematic review.

Ydemann M, Eddelien HS, Lauritsen AØ
Dan Med J 2012 Oct;59(10):A4511. PMID: 23158890

Interventions for preventing critical illness polyneuropathy and critical illness myopathy.

Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G
Cochrane Database Syst Rev 2009 Jan 21;(1):CD006832. doi: 10.1002/14651858.CD006832.pub2. PMID: 19160304

See all (10)

MedGen

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Critical illness myopathy

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity