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Toxic anterior segment syndrome

MedGen UID:
736110
•Concept ID:
C1561982
•
Disease or Syndrome
Synonyms: TASS - toxic anterior segment syndrome; Toxic Anterior Segment Syndrome
SNOMED CT: Toxic anterior segment syndrome (417079005); TASS - toxic anterior segment syndrome (417079005)

Definition

An acute postoperative inflammatory reaction in which a noninfectious substance enters the anterior segment of the eye and induces toxic damage to the intraocular tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic anterior segment syndrome

Professional guidelines

PubMed

Intracameral r-tPA for the management of severe fibrinous reactions in TASS after cataract surgery.
Osaadon P, Belfair N, Lavy I, Walter E, Levy J, Tuuminen R, Achiron A, Knyazer B
Eur J Ophthalmol 2022 Jan;32(1):200-204. Epub 2021 Mar 15 doi: 10.1177/11206721211002064. PMID: 33719630
Prevention and management of postoperative endophthalmitis: A case-based approach.
Verma L, Chakravarti A
Indian J Ophthalmol 2017 Dec;65(12):1396-1402. doi: 10.4103/ijo.IJO_1058_17. PMID: 29208820Free PMC Article

Recent clinical studies

Etiology

Late-onset toxic anterior segment syndrome after possible aluminum-contaminated and silicon-contaminated intraocular lens implantation.
Wijnants D, Delbeke H, Van Calster J, Beerlandt N, Nijs I, Werner L, Mamalis N, Saelens I
J Cataract Refract Surg 2022 Apr 1;48(4):443-448. doi: 10.1097/j.jcrs.0000000000000783. PMID: 34417782
The association between toxic anterior segment syndrome and intraocular pressure.
Shouchane-Blum K, Gershoni A, Mimouni M, Zahavi A, Segal O, Geffen N
Graefes Arch Clin Exp Ophthalmol 2021 Feb;259(2):425-430. Epub 2020 Sep 11 doi: 10.1007/s00417-020-04881-8. PMID: 32915277
The evolution of toxic anterior segment syndrome.
Shouchane-Blum K, Dotan A, Bahar I
Curr Opin Ophthalmol 2019 Jan;30(1):50-55. doi: 10.1097/ICU.0000000000000540. PMID: 30489360
Corneal edema after phacoemulsification.
Sharma N, Singhal D, Nair SP, Sahay P, Sreeshankar SS, Maharana PK
Indian J Ophthalmol 2017 Dec;65(12):1381-1389. doi: 10.4103/ijo.IJO_871_17. PMID: 29208818Free PMC Article
Toxic anterior segment syndrome--more than sterility meets the eye.
Johnston J
AORN J 2006 Dec;84(6):969-84; quiz 985-6. doi: 10.1016/s0001-2092(06)63994-x. PMID: 17216881

Diagnosis

Cases of toxic anterior segment syndrome after primary pterygium surgery.
Karatas Durusoy G, Gümüş G, Öcal MC, Kara N
Int Ophthalmol 2022 Oct;42(10):3229-3235. Epub 2022 May 14 doi: 10.1007/s10792-022-02325-2. PMID: 35567693
Toxic anterior segment syndrome: A review.
Hernandez-Bogantes E, Navas A, Naranjo A, Amescua G, Graue-Hernandez EO, Flynn HW Jr, Ahmed I
Surv Ophthalmol 2019 Jul-Aug;64(4):463-476. Epub 2019 Jan 28 doi: 10.1016/j.survophthal.2019.01.009. PMID: 30703402
The evolution of toxic anterior segment syndrome.
Shouchane-Blum K, Dotan A, Bahar I
Curr Opin Ophthalmol 2019 Jan;30(1):50-55. doi: 10.1097/ICU.0000000000000540. PMID: 30489360
Toxic anterior segment syndrome-an updated review.
Park CY, Lee JK, Chuck RS
BMC Ophthalmol 2018 Oct 25;18(1):276. doi: 10.1186/s12886-018-0939-3. PMID: 30359246Free PMC Article
Toxic anterior segment syndrome.
Mamalis N, Edelhauser HF, Dawson DG, Chew J, LeBoyer RM, Werner L
J Cataract Refract Surg 2006 Feb;32(2):324-33. doi: 10.1016/j.jcrs.2006.01.065. PMID: 16565012

Therapy

Barium-induced toxic anterior segment syndrome.
Matsushita K, Kawashima R, Hashida N, Hamano Y, Harada K, Higashisaka K, Baba K, Sato S, Huang W, Matsumoto H, Hamanaka T, Quantock AJ, Nishida K
Eur J Ophthalmol 2023 May;33(3):NP31-NP35. Epub 2021 Dec 30 doi: 10.1177/11206721211069223. PMID: 34967228
Toxic anterior segment syndrome: A review.
Hernandez-Bogantes E, Navas A, Naranjo A, Amescua G, Graue-Hernandez EO, Flynn HW Jr, Ahmed I
Surv Ophthalmol 2019 Jul-Aug;64(4):463-476. Epub 2019 Jan 28 doi: 10.1016/j.survophthal.2019.01.009. PMID: 30703402
The evolution of toxic anterior segment syndrome.
Shouchane-Blum K, Dotan A, Bahar I
Curr Opin Ophthalmol 2019 Jan;30(1):50-55. doi: 10.1097/ICU.0000000000000540. PMID: 30489360
Toxic anterior segment syndrome-an updated review.
Park CY, Lee JK, Chuck RS
BMC Ophthalmol 2018 Oct 25;18(1):276. doi: 10.1186/s12886-018-0939-3. PMID: 30359246Free PMC Article
Toxic anterior segment syndrome.
Mamalis N, Edelhauser HF, Dawson DG, Chew J, LeBoyer RM, Werner L
J Cataract Refract Surg 2006 Feb;32(2):324-33. doi: 10.1016/j.jcrs.2006.01.065. PMID: 16565012

Prognosis

Toxic anterior segment syndrome (TASS): A review and update.
Verma L, Malik A, Maharana PK, Dada T, Sharma N
Indian J Ophthalmol 2024 Jan 1;72(1):11-18. Epub 2023 Dec 22 doi: 10.4103/IJO.IJO_1796_23. PMID: 38131565Free PMC Article
Late-onset toxic anterior segment syndrome after possible aluminum-contaminated and silicon-contaminated intraocular lens implantation.
Wijnants D, Delbeke H, Van Calster J, Beerlandt N, Nijs I, Werner L, Mamalis N, Saelens I
J Cataract Refract Surg 2022 Apr 1;48(4):443-448. doi: 10.1097/j.jcrs.0000000000000783. PMID: 34417782
Toxic anterior segment syndrome: A review.
Hernandez-Bogantes E, Navas A, Naranjo A, Amescua G, Graue-Hernandez EO, Flynn HW Jr, Ahmed I
Surv Ophthalmol 2019 Jul-Aug;64(4):463-476. Epub 2019 Jan 28 doi: 10.1016/j.survophthal.2019.01.009. PMID: 30703402
Toxic anterior segment syndrome-an updated review.
Park CY, Lee JK, Chuck RS
BMC Ophthalmol 2018 Oct 25;18(1):276. doi: 10.1186/s12886-018-0939-3. PMID: 30359246Free PMC Article
Outbreak of Subacute-Onset Toxic Anterior Segment Syndrome Associated with Single-Piece Acrylic Intraocular Lenses.
Oshika T, Eguchi S, Goto H, Ohashi Y
Ophthalmology 2017 Apr;124(4):519-523. Epub 2017 Jan 19 doi: 10.1016/j.ophtha.2016.12.010. PMID: 28110952

Clinical prediction guides

Late-onset toxic anterior segment syndrome after possible aluminum-contaminated and silicon-contaminated intraocular lens implantation.
Wijnants D, Delbeke H, Van Calster J, Beerlandt N, Nijs I, Werner L, Mamalis N, Saelens I
J Cataract Refract Surg 2022 Apr 1;48(4):443-448. doi: 10.1097/j.jcrs.0000000000000783. PMID: 34417782
Outbreak of Subacute-Onset Toxic Anterior Segment Syndrome Associated with Single-Piece Acrylic Intraocular Lenses.
Oshika T, Eguchi S, Goto H, Ohashi Y
Ophthalmology 2017 Apr;124(4):519-523. Epub 2017 Jan 19 doi: 10.1016/j.ophtha.2016.12.010. PMID: 28110952
The Food and Drug Administration's Proactive toxic anterior segment syndrome Program.
Eydelman MB, Tarver ME, Calogero D, Buchen SY, Alexander KY
Ophthalmology 2012 Jul;119(7):1297-302. Epub 2012 May 11 doi: 10.1016/j.ophtha.2012.04.008. PMID: 22578447
Toxic anterior segment syndrome subsequent to pediatric cataract surgery.
Ari S, Caca I, Sahin A, Cingü AK
Cutan Ocul Toxicol 2012 Mar;31(1):53-7. Epub 2011 Sep 23 doi: 10.3109/15569527.2011.613426. PMID: 21939434
Toxic anterior segment syndrome after uncomplicated cataract surgery.
Ozcelik ND, Eltutar K, Bilgin B
Eur J Ophthalmol 2010 Jan-Feb;20(1):106-14. doi: 10.1177/112067211002000114. PMID: 19927269

Recent systematic reviews

The safety of intracameral phenylephrine - A systematic review.
Gowda A, Jie WWJ, Casson R, Chan WO
Surv Ophthalmol 2022 Sep-Oct;67(5):1540-1546. Epub 2022 Jun 9 doi: 10.1016/j.survophthal.2022.06.002. PMID: 35691387
Risks of Cefuroxime Prophylaxis for Postcataract Endophthalmitis.
Al-Abduljabbar KA, Stone DU
Middle East Afr J Ophthalmol 2017 Jan-Mar;24(1):24-29. doi: 10.4103/meajo.MEAJO_255_16. PMID: 28546689Free PMC Article

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