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Chemical pregnancy

MedGen UID:
754205
•Concept ID:
C2919902
•
Pathologic Function
Synonyms: Chemical Pregnancy; Peri-Implantational Failure; Peri-Implantational Loss
SNOMED CT: Chemical pregnancy (445086005)

Definition

Pregnancy loss before 5th week of gestation with no gestational sac visible on ultrasonogram. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemical pregnancy

Professional guidelines

PubMed

Novel modified criteria for sperm morphology in oocyte insemination could reduce ICSI rates without affecting IVF outcomes.
Lin TK, Chan LL, Lai TH, Lo HC
Taiwan J Obstet Gynecol 2023 Jul;62(4):525-529. doi: 10.1016/j.tjog.2023.04.003. PMID: 37407188
Pentoxifylline treatment had no detrimental effect on sperm DNA integrity and clinical characteristics in cases with non-obstructive azoospermia.
Mahaldashtian M, Khalili MA, Mangoli E, Zavereh S, Anbari F
Zygote 2023 Feb;31(1):8-13. Epub 2022 Oct 19 doi: 10.1017/S0967199422000247. PMID: 36258642
Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos.
Gleicher N, Vidali A, Braverman J, Kushnir VA, Barad DH, Hudson C, Wu YG, Wang Q, Zhang L, Albertini DF; International PGS Consortium Study Group
Reprod Biol Endocrinol 2016 Sep 5;14(1):54. doi: 10.1186/s12958-016-0193-6. PMID: 27595768Free PMC Article

Recent clinical studies

Etiology

Multicenter, 2-dose single-group controlled trial of tacrolimus for the severe infertility patients.
Hisano M, Nakagawa K, Ono M, Yoshino O, Saito T, Hirota Y, Inoue E, Kikuchi K, Nakamura H, Yamaguchi K
Medicine (Baltimore) 2023 Aug 11;102(32):e34317. doi: 10.1097/MD.0000000000034317. PMID: 37565878Free PMC Article
Clinical pregnancy rate for frozen embryo transfer with HRT: a randomized controlled pilot study comparing 1 week versus 2 weeks of oestradiol priming.
Racca A, Santos-Ribeiro S, Drakopoulos P, De Coppel J, Van Landuyt L, Tournaye H, Blockeel C
Reprod Biol Endocrinol 2023 Jul 7;21(1):62. doi: 10.1186/s12958-023-01111-8. PMID: 37420186Free PMC Article
The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis.
Maged AM, El-Mazny A, Kamal N, Mahmoud SI, Fouad M, El-Nassery N, Kotb A, Ragab WS, Ogila AI, Metwally AA, Fahmy RM, Saad H, Shaeer EK, Salah N, Lasheen Y
J Assist Reprod Genet 2023 May;40(5):969-983. Epub 2023 Apr 3 doi: 10.1007/s10815-023-02781-4. PMID: 37010710Free PMC Article
Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.
Azizi-Kutenaee M, Heidari S, Taghavi SA, Bazarganipour F
BMC Womens Health 2022 Sep 12;22(1):373. doi: 10.1186/s12905-022-01955-z. PMID: 36096842Free PMC Article
Pregnancy outcome prediction after embryo transfer based on serum human chorionic gonadotrophin concentrations.
Balasičová Katarína, Kraus Andrea, Peterová Lucia, Nykolaichuk Roksolana, Toporcerová Silvia
Ceska Gynekol 2022;87(1):4-12. doi: 10.48095/cccg20224. PMID: 35240830

Diagnosis

High Anti-Müllerian Hormone Strongly Correlates with Reproductive Outcomes in Women Undergoing Assisted Reproduction.
Jabarpour M, Amidi F, Rostami S, Aleyasin A, Aghahosseini M, Khodarahmian M, Najafian A, Hosseinimousa S, Abbasi Y, Nashtaei MS
Clin Lab 2023 Dec 1;69(12) doi: 10.7754/Clin.Lab.2023.230524. PMID: 38084695
Danaparoid is effective and safe for patients with obstetric antiphospholipid syndrome.
Yoshihara H, Sugiura-Ogasawara M, Kitaori T, Katano K, Ozaki Y
Mod Rheumatol 2020 Mar;30(2):332-337. Epub 2019 Apr 24 doi: 10.1080/14397595.2019.1602241. PMID: 30924705
Heart rate variability among women undergoing in vitro fertilization treatment: Its predictive ability for pregnancy.
Wu MH, Su PF, Chen KY, Tie TH, Ke HC, Chen H, Su YC, Su YC, Ou HT
PLoS One 2018;13(3):e0193899. Epub 2018 Mar 12 doi: 10.1371/journal.pone.0193899. PMID: 29529100Free PMC Article
Absolute position versus relative position in embryo transfer: a randomized controlled trial.
Kwon H, Choi DH, Kim EK
Reprod Biol Endocrinol 2015 Jul 29;13:78. doi: 10.1186/s12958-015-0072-6. PMID: 26216410Free PMC Article
Uterine length and fertility outcomes: a cohort study in the IVF population.
Hawkins LK, Correia KF, Srouji SS, Hornstein MD, Missmer SA
Hum Reprod 2013 Nov;28(11):3000-6. Epub 2013 Sep 5 doi: 10.1093/humrep/det344. PMID: 24014604

Therapy

Multicenter, 2-dose single-group controlled trial of tacrolimus for the severe infertility patients.
Hisano M, Nakagawa K, Ono M, Yoshino O, Saito T, Hirota Y, Inoue E, Kikuchi K, Nakamura H, Yamaguchi K
Medicine (Baltimore) 2023 Aug 11;102(32):e34317. doi: 10.1097/MD.0000000000034317. PMID: 37565878Free PMC Article
Clinical pregnancy rate for frozen embryo transfer with HRT: a randomized controlled pilot study comparing 1 week versus 2 weeks of oestradiol priming.
Racca A, Santos-Ribeiro S, Drakopoulos P, De Coppel J, Van Landuyt L, Tournaye H, Blockeel C
Reprod Biol Endocrinol 2023 Jul 7;21(1):62. doi: 10.1186/s12958-023-01111-8. PMID: 37420186Free PMC Article
Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.
Azizi-Kutenaee M, Heidari S, Taghavi SA, Bazarganipour F
BMC Womens Health 2022 Sep 12;22(1):373. doi: 10.1186/s12905-022-01955-z. PMID: 36096842Free PMC Article
Luteal phase support for natural cycle frozen embryo transfer: a meta-analysis.
Su S, Zeng M, Duan J
Gynecol Endocrinol 2022 Feb;38(2):116-123. Epub 2021 Nov 3 doi: 10.1080/09513590.2021.1998438. PMID: 34730071
Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial.
Aleyasin A, Abediasl Z, Nazari A, Sheikh M
Reproduction 2016 Jun;151(6):637-42. Epub 2016 Mar 15 doi: 10.1530/REP-16-0046. PMID: 26980809

Prognosis

High Anti-Müllerian Hormone Strongly Correlates with Reproductive Outcomes in Women Undergoing Assisted Reproduction.
Jabarpour M, Amidi F, Rostami S, Aleyasin A, Aghahosseini M, Khodarahmian M, Najafian A, Hosseinimousa S, Abbasi Y, Nashtaei MS
Clin Lab 2023 Dec 1;69(12) doi: 10.7754/Clin.Lab.2023.230524. PMID: 38084695
Pregnancy outcome prediction after embryo transfer based on serum human chorionic gonadotrophin concentrations.
Balasičová Katarína, Kraus Andrea, Peterová Lucia, Nykolaichuk Roksolana, Toporcerová Silvia
Ceska Gynekol 2022;87(1):4-12. doi: 10.48095/cccg20224. PMID: 35240830
Assessing ICSI outcome by combining non-invasive indicators: Early time-lapse morphokinetics and apoptosis in associated cumulus cells among women with the polycystic ovarian syndrome.
Tabibnejad N, Aflatoonian A, Motamedzadeh L, Soleimani M, Sadeghian-Nodoushan F, Talebi AR
Mol Reprod Dev 2018 Nov;85(11):865-874. Epub 2018 Aug 20 doi: 10.1002/mrd.23044. PMID: 29995338
Heart rate variability among women undergoing in vitro fertilization treatment: Its predictive ability for pregnancy.
Wu MH, Su PF, Chen KY, Tie TH, Ke HC, Chen H, Su YC, Su YC, Ou HT
PLoS One 2018;13(3):e0193899. Epub 2018 Mar 12 doi: 10.1371/journal.pone.0193899. PMID: 29529100Free PMC Article
Point of failure as a predictor of in vitro fertilization treatment discontinuation.
Pearson KR, Hauser R, Cramer DW, Missmer SA
Fertil Steril 2009 Apr;91(4 Suppl):1483-5. Epub 2008 Sep 30 doi: 10.1016/j.fertnstert.2008.07.1732. PMID: 18829010Free PMC Article

Clinical prediction guides

Clinical pregnancy rate for frozen embryo transfer with HRT: a randomized controlled pilot study comparing 1 week versus 2 weeks of oestradiol priming.
Racca A, Santos-Ribeiro S, Drakopoulos P, De Coppel J, Van Landuyt L, Tournaye H, Blockeel C
Reprod Biol Endocrinol 2023 Jul 7;21(1):62. doi: 10.1186/s12958-023-01111-8. PMID: 37420186Free PMC Article
Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.
Azizi-Kutenaee M, Heidari S, Taghavi SA, Bazarganipour F
BMC Womens Health 2022 Sep 12;22(1):373. doi: 10.1186/s12905-022-01955-z. PMID: 36096842Free PMC Article
Pregnancy outcome prediction after embryo transfer based on serum human chorionic gonadotrophin concentrations.
Balasičová Katarína, Kraus Andrea, Peterová Lucia, Nykolaichuk Roksolana, Toporcerová Silvia
Ceska Gynekol 2022;87(1):4-12. doi: 10.48095/cccg20224. PMID: 35240830
The impact of emotional health on assisted reproductive technology outcomes: a systematic review and meta-analysis.
Peaston G, Subramanian V, Brunckhorst O, Sarris I, Ahmed K
Hum Fertil (Camb) 2022 Jul;25(3):410-421. Epub 2020 Oct 14 doi: 10.1080/14647273.2020.1832262. PMID: 33050764
Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes.
Eftekhar M, Mirhashemi ES, Tabibnejad N
Int J Gynaecol Obstet 2019 Feb;144(2):147-152. Epub 2018 Nov 26 doi: 10.1002/ijgo.12707. PMID: 30411351

Recent systematic reviews

The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis.
Maged AM, El-Mazny A, Kamal N, Mahmoud SI, Fouad M, El-Nassery N, Kotb A, Ragab WS, Ogila AI, Metwally AA, Fahmy RM, Saad H, Shaeer EK, Salah N, Lasheen Y
J Assist Reprod Genet 2023 May;40(5):969-983. Epub 2023 Apr 3 doi: 10.1007/s10815-023-02781-4. PMID: 37010710Free PMC Article
Effect of intrauterine infusion of platelet-rich plasma for women with recurrent implantation failure: a systematic review and meta-analysis.
Deng H, Wang S, Li Z, Xiao L, Ma L
J Obstet Gynaecol 2023 Dec;43(1):2144177. Epub 2022 Nov 17 doi: 10.1080/01443615.2022.2144177. PMID: 36397660
Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials.
Zhou X, Wu X, Luo X, Shao J, Guo D, Deng B, Wu Z
Front Endocrinol (Lausanne) 2022;13:852428. Epub 2022 Mar 17 doi: 10.3389/fendo.2022.852428. PMID: 35370977Free PMC Article
The impact of emotional health on assisted reproductive technology outcomes: a systematic review and meta-analysis.
Peaston G, Subramanian V, Brunckhorst O, Sarris I, Ahmed K
Hum Fertil (Camb) 2022 Jul;25(3):410-421. Epub 2020 Oct 14 doi: 10.1080/14647273.2020.1832262. PMID: 33050764
The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010).
Kleiman SE, Yogev L, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, Gamzu R
Fertil Steril 2011 May;95(6):2005-12, 2012.e1-4. Epub 2011 Mar 1 doi: 10.1016/j.fertnstert.2011.01.162. PMID: 21367410

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