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Vesicular stomatitis

MedGen UID:
75624
•Concept ID:
C0266999
•
Disease or Syndrome
Synonyms: Stomatitides, Vesicular; Stomatitis, Vesicular; Vesicular Stomatitides; Vesicular Stomatitis
SNOMED CT: Vesicular stomatitis (36921006)

Definition

A viral disease caused by at least two distinct species (serotypes) in the VESICULOVIRUS genus: VESICULAR STOMATITIS INDIANA VIRUS and VESICULAR STOMATITIS NEW JERSEY VIRUS. It is characterized by vesicular eruptions on the ORAL MUCOSA in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVesicular stomatitis

Professional guidelines

PubMed

Recent advances in the treatment of Ebola disease: A brief overview.
El Ayoubi LW, Mahmoud O, Zakhour J, Kanj SS
PLoS Pathog 2024 Mar;20(3):e1012038. Epub 2024 Mar 15 doi: 10.1371/journal.ppat.1012038. PMID: 38489257Free PMC Article
Efficient Delivery and Replication of Oncolytic Virus for Successful Treatment of Head and Neck Cancer.
Hamada M, Yura Y
Int J Mol Sci 2020 Sep 25;21(19) doi: 10.3390/ijms21197073. PMID: 32992948Free PMC Article
Potential and emerging treatment options for Ebola virus disease.
Bishop BM
Ann Pharmacother 2015 Feb;49(2):196-206. Epub 2014 Nov 20 doi: 10.1177/1060028014561227. PMID: 25414384

Recent clinical studies

Etiology

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis.
Erttmann SF, Swacha P, Aung KM, Brindefalk B, Jiang H, Härtlova A, Uhlin BE, Wai SN, Gekara NO
Immunity 2022 May 10;55(5):847-861.e10. doi: 10.1016/j.immuni.2022.04.006. PMID: 35545033
Structures of the Mononegavirales Polymerases.
Liang B
J Virol 2020 Oct 27;94(22) doi: 10.1128/JVI.00175-20. PMID: 32847861Free PMC Article
Human Tibroviruses: Commensals or Lethal Pathogens?
Kuhn JH, Pān H, Chiu CY, Stremlau M
Viruses 2020 Feb 25;12(3) doi: 10.3390/v12030252. PMID: 32106547Free PMC Article
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Xiao J, Li W, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B, Wang H
Immunity 2020 Jan 14;52(1):109-122.e6. Epub 2019 Dec 24 doi: 10.1016/j.immuni.2019.11.015. PMID: 31882361
Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).
Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Gunther S, Gsell PS, Hossmann S, Watle SV, Kondé MK, Kéïta S, Kone S, Kuisma E, Levine MM, Mandal S, Mauget T, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Røttingen JA, Kieny MP
Lancet 2017 Feb 4;389(10068):505-518. Epub 2016 Dec 23 doi: 10.1016/S0140-6736(16)32621-6. PMID: 28017403Free PMC Article

Diagnosis

SERINC5 restricts influenza virus infectivity.
Zhao F, Xu F, Liu X, Hu Y, Wei L, Fan Z, Wang L, Huang Y, Mei S, Guo L, Yang L, Cen S, Wang J, Liang C, Guo F
PLoS Pathog 2022 Oct;18(10):e1010907. Epub 2022 Oct 12 doi: 10.1371/journal.ppat.1010907. PMID: 36223419Free PMC Article
Direct trafficking pathways from the Golgi apparatus to the plasma membrane.
Stalder D, Gershlick DC
Semin Cell Dev Biol 2020 Nov;107:112-125. Epub 2020 Apr 13 doi: 10.1016/j.semcdb.2020.04.001. PMID: 32317144Free PMC Article
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.
Nie J, Li Q, Wu J, Zhao C, Hao H, Liu H, Zhang L, Nie L, Qin H, Wang M, Lu Q, Li X, Sun Q, Liu J, Fan C, Huang W, Xu M, Wang Y
Emerg Microbes Infect 2020 Dec;9(1):680-686. doi: 10.1080/22221751.2020.1743767. PMID: 32207377Free PMC Article
TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.
Rihn SJ, Aziz MA, Stewart DG, Hughes J, Turnbull ML, Varela M, Sugrue E, Herd CS, Stanifer M, Sinkins SP, Palmarini M, Wilson SJ
J Virol 2019 Oct 15;93(20) Epub 2019 Sep 30 doi: 10.1128/JVI.00951-19. PMID: 31375575Free PMC Article
Antiviral mechanisms of human defensins.
Wilson SS, Wiens ME, Smith JG
J Mol Biol 2013 Dec 13;425(24):4965-80. Epub 2013 Oct 2 doi: 10.1016/j.jmb.2013.09.038. PMID: 24095897Free PMC Article

Therapy

Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases.
Wang S, Liang B, Wang W, Li L, Feng N, Zhao Y, Wang T, Yan F, Yang S, Xia X
Signal Transduct Target Ther 2023 Apr 7;8(1):149. doi: 10.1038/s41392-023-01408-5. PMID: 37029123Free PMC Article
A tool with many applications: vesicular stomatitis virus in research and medicine.
Munis AM, Bentley EM, Takeuchi Y
Expert Opin Biol Ther 2020 Oct;20(10):1187-1201. Epub 2020 Jul 9 doi: 10.1080/14712598.2020.1787981. PMID: 32602788
Systemic virotherapy for multiple myeloma.
Oliva S, Gambella M, Boccadoro M, Bringhen S
Expert Opin Biol Ther 2017 Nov;17(11):1375-1387. Epub 2017 Aug 10 doi: 10.1080/14712598.2017.1364359. PMID: 28796556
Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).
Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Gunther S, Gsell PS, Hossmann S, Watle SV, Kondé MK, Kéïta S, Kone S, Kuisma E, Levine MM, Mandal S, Mauget T, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Røttingen JA, Kieny MP
Lancet 2017 Feb 4;389(10068):505-518. Epub 2016 Dec 23 doi: 10.1016/S0140-6736(16)32621-6. PMID: 28017403Free PMC Article
Ebola virus (EBOV) infection: Therapeutic strategies.
De Clercq E
Biochem Pharmacol 2015 Jan 1;93(1):1-10. Epub 2014 Dec 4 doi: 10.1016/j.bcp.2014.11.008. PMID: 25481298Free PMC Article

Prognosis

A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses.
Smith KER, Peng KW, Pulido JS, Weisbrod AJ, Strand CA, Allred JB, Newsom AN, Zhang L, Packiriswamy N, Kottke T, Tonne JM, Moore M, Montane HN, Kottschade LA, McWilliams RR, Dudek AZ, Yan Y, Dimou A, Markovic SN, Federspiel MJ, Vile RG, Dronca RS, Block MS
Front Immunol 2023;14:1279387. Epub 2023 Oct 31 doi: 10.3389/fimmu.2023.1279387. PMID: 38022659Free PMC Article
ASK1 inhibitors are potential pan-antiviral drugs, which dampen replication of diverse viruses including SARS-CoV2.
Demian WL, Jacob RA, Cormier O, Nazli A, Melki M, Asavajaru A, Baid K, Zhang A, Miller MS, Kaushic C, Banerjee A, Mossman K
Antiviral Res 2023 Dec;220:105736. Epub 2023 Oct 18 doi: 10.1016/j.antiviral.2023.105736. PMID: 37863359
Vesicular Stomatitis Virus (VSV) G Glycoprotein Can Be Modified to Create a Her2/Neu-Targeted VSV That Eliminates Large Implanted Mammary Tumors.
Gao Y, Bergman I
J Virol 2023 Jun 29;97(6):e0037223. Epub 2023 May 18 doi: 10.1128/jvi.00372-23. PMID: 37199666Free PMC Article
Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?
Huttner A, Siegrist CA
Expert Rev Vaccines 2018 Dec;17(12):1105-1110. Epub 2018 Nov 15 doi: 10.1080/14760584.2018.1546582. PMID: 30422031
Foot- and-mouth disease as zoonosis.
Bauer K
Arch Virol Suppl 1997;13:95-7. doi: 10.1007/978-3-7091-6534-8_9. PMID: 9413529

Clinical prediction guides

Intertumoral heterogeneity impacts oncolytic vesicular stomatitis virus efficacy in mouse pancreatic cancer cells.
Goad DW, Nesmelova AY, Yohe LR, Grdzelishvili VZ
J Virol 2023 Sep 28;97(9):e0100523. Epub 2023 Sep 6 doi: 10.1128/jvi.01005-23. PMID: 37671865Free PMC Article
Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?
Huttner A, Siegrist CA
Expert Rev Vaccines 2018 Dec;17(12):1105-1110. Epub 2018 Nov 15 doi: 10.1080/14760584.2018.1546582. PMID: 30422031
The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials.
Suder E, Furuyama W, Feldmann H, Marzi A, de Wit E
Hum Vaccin Immunother 2018;14(9):2107-2113. Epub 2018 Jun 18 doi: 10.1080/21645515.2018.1473698. PMID: 29757706Free PMC Article
The interferon response to intracellular DNA: why so many receptors?
Unterholzner L
Immunobiology 2013 Nov;218(11):1312-21. Epub 2013 Jul 29 doi: 10.1016/j.imbio.2013.07.007. PMID: 23962476
Emergence and re-emergence of vesicular stomatitis in the United States.
Rodríguez LL
Virus Res 2002 May 10;85(2):211-9. doi: 10.1016/s0168-1702(02)00026-6. PMID: 12034487

Recent systematic reviews

Filtering Facepiece Respirator (N95 Respirator) Reprocessing: A Systematic Review.
Schumm MA, Hadaya JE, Mody N, Myers BA, Maggard-Gibbons M
JAMA 2021 Apr 6;325(13):1296-1317. doi: 10.1001/jama.2021.2531. PMID: 33656543
Systematic review of Marburg virus vaccine nonhuman primate studies and human clinical trials.
Dulin N, Spanier A, Merino K, Hutter JN, Waterman PE, Lee C, Hamer MJ
Vaccine 2021 Jan 8;39(2):202-208. Epub 2020 Dec 9 doi: 10.1016/j.vaccine.2020.11.042. PMID: 33309082
A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option.
Peterson A, Bansal A, Hofman F, Chen TC, Zada G
J Neurooncol 2014 Feb;116(3):437-46. Epub 2014 Jan 8 doi: 10.1007/s11060-013-1346-5. PMID: 24398618
Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc.: a review.
Peng W, Qin R, Li X, Zhou H
J Ethnopharmacol 2013 Jul 30;148(3):729-45. Epub 2013 May 22 doi: 10.1016/j.jep.2013.05.007. PMID: 23707210

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