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Adult malignant schwannoma

MedGen UID:
75845
•Concept ID:
C0278622
•
Neoplastic Process
Synonyms: Adult Malignant Neoplasm of Peripheral Nerve Sheath; adult malignant neoplasm of peripheral nerve sheath; Adult Malignant Neoplasm of the Peripheral Nerve Sheath; adult malignant neoplasm of the peripheral nerve sheath; Adult Malignant Neurilemmoma; adult malignant neurilemmoma; Adult Malignant Peripheral Nerve Sheath Neoplasm; adult malignant peripheral nerve sheath neoplasm; Adult Malignant Peripheral Nerve Sheath Tumor; adult malignant peripheral nerve sheath tumor; adult malignant peripheral nerve sheath tumour; Adult Malignant Schwannoma; adult malignant schwannoma; Adult Malignant Tumor of Peripheral Nerve Sheath; adult malignant tumor of peripheral nerve sheath; Adult Malignant Tumor of the Peripheral Nerve Sheath; adult malignant tumor of the peripheral nerve sheath; adult malignant tumour of peripheral nerve sheath; adult malignant tumour of the peripheral nerve sheath; Adult MPNST; adult MPNST
 
Monarch Initiative: MONDO:0004545

Definition

A malignant peripheral nerve sheath tumor occurring during adulthood. [from NCI]

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369

Recent clinical studies

Etiology

Management of Central and Peripheral Nervous System Tumors in Patients with Neurofibromatosis.
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Primary bronchial schwannoma: A case report.
Aoyama Y, Miyamoto A, Fujii T, Fujimori S, Tamaoka M, Takai D
Medicine (Baltimore) 2022 Oct 7;101(40):e31062. doi: 10.1097/MD.0000000000031062. PMID: 36221358Free PMC Article
Pediatric neurofibrosarcoma.
Neville H, Corpron C, Blakely ML, Andrassy R
J Pediatr Surg 2003 Mar;38(3):343-6; discussion 343-6. doi: 10.1053/jpsu.2003.50105. PMID: 12632346
Sinonasal neurogenic tumours.
Vaideeswar P, Madiwale CV, Kathpal D, Prabhat DP
Indian J Pathol Microbiol 2002 Apr;45(2):161-3. PMID: 12696731
Extraskeletal osteosarcoma.
Chung EB, Enzinger FM
Cancer 1987 Sep 1;60(5):1132-42. doi: 10.1002/1097-0142(19870901)60:5<1132::aid-cncr2820600536>3.0.co;2-l. PMID: 3475157

Diagnosis

Primary bronchial schwannoma: A case report.
Aoyama Y, Miyamoto A, Fujii T, Fujimori S, Tamaoka M, Takai D
Medicine (Baltimore) 2022 Oct 7;101(40):e31062. doi: 10.1097/MD.0000000000031062. PMID: 36221358Free PMC Article
Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369
Intrasclera schwannoma.
Hosseini H, Eghtedari M, Roozitalab M, Ashraf M, Shahrzad S
BMJ Case Rep 2011 Mar 3;2011 doi: 10.1136/bcr.07.2010.3158. PMID: 22707621Free PMC Article

Therapy

Management of Central and Peripheral Nervous System Tumors in Patients with Neurofibromatosis.
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Laparoscopic partial splenectomy.
Uranues S, Grossman D, Ludwig L, Bergamaschi R
Surg Endosc 2007 Jan;21(1):57-60. Epub 2006 Oct 9 doi: 10.1007/s00464-006-0124-2. PMID: 17031738
Postirradiation neurofibrosarcoma.
Ducatman BS, Scheithauer BW
Cancer 1983 Mar 15;51(6):1028-33. doi: 10.1002/1097-0142(19830315)51:6<1028::aid-cncr2820510610>3.0.co;2-3. PMID: 6821867
Malignant schwannoma--clinical characteristics, survival, and response to therapy.
Sordillo PP, Helson L, Hajdu SI, Magill GB, Kosloff C, Golbey RB, Beattie EJ
Cancer 1981 May 15;47(10):2503-9. doi: 10.1002/1097-0142(19810515)47:10<2503::aid-cncr2820471033>3.0.co;2-3. PMID: 6791802
Neurofibrosarcoma.
Storm FK, Eilber FR, Mirra J, Morton DL
Cancer 1980 Jan 1;45(1):126-9. doi: 10.1002/1097-0142(19800101)45:1<126::aid-cncr2820450122>3.0.co;2-u. PMID: 6766081

Prognosis

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Intraocular schwannoma.
You JY, Finger PT, Iacob C, McCormick SA, Milman T
Surv Ophthalmol 2013 Jan-Feb;58(1):77-85. Epub 2012 Sep 14 doi: 10.1016/j.survophthal.2012.04.003. PMID: 22981398
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Adrenal schwannoma.
Târcoveanu E, Dimofte G, Bradea C, Moldovanu R, Vasilescu A, Anton R, Ferariu D
JSLS 2009 Jan-Mar;13(1):116-9. PMID: 19366556Free PMC Article
Neurofibrosarcoma.
Storm FK, Eilber FR, Mirra J, Morton DL
Cancer 1980 Jan 1;45(1):126-9. doi: 10.1002/1097-0142(19800101)45:1<126::aid-cncr2820450122>3.0.co;2-u. PMID: 6766081

Clinical prediction guides

Primary bronchial schwannoma: A case report.
Aoyama Y, Miyamoto A, Fujii T, Fujimori S, Tamaoka M, Takai D
Medicine (Baltimore) 2022 Oct 7;101(40):e31062. doi: 10.1097/MD.0000000000031062. PMID: 36221358Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Plexiform schwannoma.
Megahed M
Am J Dermatopathol 1994 Jun;16(3):288-93. doi: 10.1097/00000372-199406000-00011. PMID: 7943637

Recent systematic reviews

Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case.
Lenartowicz KA, Monie DD, Amrami KK, Klein CJ, Giannini C, Spinner RJ
Acta Neurochir (Wien) 2023 Apr;165(4):935-945. Epub 2022 Nov 18 doi: 10.1007/s00701-022-05413-5. PMID: 36396843Free PMC Article
Malignant peripheral nerve sheath tumour of the oral and maxillofacial region-A systematic review.
Schuch LF, Kirschnick LB, de Arruda JAA, Klein IP, Silveira FM, Vasconcelos ACU, Santos-Silva AR, Lopes MA, Carrard VC, Vargas PA, Martins MAT, Wagner VP, Martins MD
Oral Dis 2022 Nov;28(8):2072-2082. Epub 2021 Aug 12 doi: 10.1111/odi.13982. PMID: 34333825
Composite phaeochromocytomas-a systematic review of published literature.
Dhanasekar K, Visakan V, Tahir F, Balasubramanian SP
Langenbecks Arch Surg 2022 Mar;407(2):517-527. Epub 2021 Mar 2 doi: 10.1007/s00423-021-02129-5. PMID: 33651160Free PMC Article
Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation.
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.
Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410

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