U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pulmonary non-tuberculous mycobacterial infection

MedGen UID:
758704
•Concept ID:
C3472679
•
Disease or Syndrome
Synonyms: Atypical mycobacterial infection of lung; Non-tuberculous mycobacterial lung disease; non-tuberculous mycobacterial lung disease; Nontuberculous mycobacterial lung disease; nontuberculous mycobacterial lung disease; Nontuberculous Mycobacterial Lung Disease; pulmonary non-tuberculous mycobacterial infection
SNOMED CT: Atypical mycobacterial infection of lung (1731000119106); Nontuberculous mycobacterial lung disease (1731000119106)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018469
Orphanet: ORPHA411703

Definition

A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including <i>Mycobacterium avium</i> complex, <i>Mycobacterium kansasii</i>, or <i>Mycobacterium xenopi</i>, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary non-tuberculous mycobacterial infection

Professional guidelines

PubMed

Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.
Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643Free PMC Article

Recent clinical studies

Etiology

Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.
Flume PA, Garcia BA, Wilson D, Steed L, Dorman SE, Winthrop K
Respir Med 2023 Jan;206:107069. Epub 2022 Dec 2 doi: 10.1016/j.rmed.2022.107069. PMID: 36493605
The antimicrobial susceptibility of non-tuberculous mycobacteria.
Cowman S, Burns K, Benson S, Wilson R, Loebinger MR
J Infect 2016 Mar;72(3):324-31. Epub 2015 Dec 24 doi: 10.1016/j.jinf.2015.12.007. PMID: 26723913
CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients.
Lee Y, Song JW, Chae EJ, Lee HJ, Lee CW, Do KH, Seo JB, Kim MY, Lee JS, Song KS, Shim TS
Br J Radiol 2013 Apr;86(1024):20120209. Epub 2013 Feb 25 doi: 10.1259/bjr.20120209. PMID: 23440166Free PMC Article
Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.
Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643Free PMC Article

Diagnosis

Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.
Setoguchi D, Iwanaga N, Ito Y, Ashizawa N, Hirayama T, Takeda K, Ide S, Takemoto S, Tashiro M, Hosogaya N, Takazono T, Sakamoto N, Obase Y, Izumikawa K, Yanagihara K, Mukae H
J Infect Chemother 2023 Jun;29(6):615-619. Epub 2023 Mar 13 doi: 10.1016/j.jiac.2023.03.010. PMID: 36921763
The antimicrobial susceptibility of non-tuberculous mycobacteria.
Cowman S, Burns K, Benson S, Wilson R, Loebinger MR
J Infect 2016 Mar;72(3):324-31. Epub 2015 Dec 24 doi: 10.1016/j.jinf.2015.12.007. PMID: 26723913
CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients.
Lee Y, Song JW, Chae EJ, Lee HJ, Lee CW, Do KH, Seo JB, Kim MY, Lee JS, Song KS, Shim TS
Br J Radiol 2013 Apr;86(1024):20120209. Epub 2013 Feb 25 doi: 10.1259/bjr.20120209. PMID: 23440166Free PMC Article
Endobronchial carcinoid tumor combined with pulmonary non-tuberculous mycobacterial infection: report of two cases.
Nakamura Y, Okada Y, Endo C, Aikawa H, Sakurada A, Sato M, Kondo T
Lung Cancer 2003 Feb;39(2):227-9. doi: 10.1016/s0169-5002(02)00450-6. PMID: 12581578
Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.
Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643Free PMC Article

Therapy

Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.
Setoguchi D, Iwanaga N, Ito Y, Ashizawa N, Hirayama T, Takeda K, Ide S, Takemoto S, Tashiro M, Hosogaya N, Takazono T, Sakamoto N, Obase Y, Izumikawa K, Yanagihara K, Mukae H
J Infect Chemother 2023 Jun;29(6):615-619. Epub 2023 Mar 13 doi: 10.1016/j.jiac.2023.03.010. PMID: 36921763
Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.
Flume PA, Garcia BA, Wilson D, Steed L, Dorman SE, Winthrop K
Respir Med 2023 Jan;206:107069. Epub 2022 Dec 2 doi: 10.1016/j.rmed.2022.107069. PMID: 36493605
Pharmacokinetics and Adverse Effects of Clofazimine in the Treatment of Pulmonary Non-Tuberculous Mycobacterial Infection.
Watanabe F, Furuuchi K, Hanada K, Fujiwara K, Uesugi F, Hiramatsu M, Yoshiyama T, Shiraishi Y, Kurashima A, Ohta K, Morimoto K
Antimicrob Agents Chemother 2022 Aug 16;66(8):e0044122. Epub 2022 Jul 7 doi: 10.1128/aac.00441-22. PMID: 35862744Free PMC Article
Endobronchial carcinoid tumor combined with pulmonary non-tuberculous mycobacterial infection: report of two cases.
Nakamura Y, Okada Y, Endo C, Aikawa H, Sakurada A, Sato M, Kondo T
Lung Cancer 2003 Feb;39(2):227-9. doi: 10.1016/s0169-5002(02)00450-6. PMID: 12581578
Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.
Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643Free PMC Article

Prognosis

Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.
Setoguchi D, Iwanaga N, Ito Y, Ashizawa N, Hirayama T, Takeda K, Ide S, Takemoto S, Tashiro M, Hosogaya N, Takazono T, Sakamoto N, Obase Y, Izumikawa K, Yanagihara K, Mukae H
J Infect Chemother 2023 Jun;29(6):615-619. Epub 2023 Mar 13 doi: 10.1016/j.jiac.2023.03.010. PMID: 36921763
CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients.
Lee Y, Song JW, Chae EJ, Lee HJ, Lee CW, Do KH, Seo JB, Kim MY, Lee JS, Song KS, Shim TS
Br J Radiol 2013 Apr;86(1024):20120209. Epub 2013 Feb 25 doi: 10.1259/bjr.20120209. PMID: 23440166Free PMC Article

Clinical prediction guides

Pharmacokinetics and Adverse Effects of Clofazimine in the Treatment of Pulmonary Non-Tuberculous Mycobacterial Infection.
Watanabe F, Furuuchi K, Hanada K, Fujiwara K, Uesugi F, Hiramatsu M, Yoshiyama T, Shiraishi Y, Kurashima A, Ohta K, Morimoto K
Antimicrob Agents Chemother 2022 Aug 16;66(8):e0044122. Epub 2022 Jul 7 doi: 10.1128/aac.00441-22. PMID: 35862744Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...