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Mixed cell type kidney Wilms tumor

MedGen UID:
76001
•Concept ID:
C0279611
•
Neoplastic Process
Synonym: Mixed cell type kidney Wilms' tumor
 
Monarch Initiative: MONDO:0003318

Definition

Wilms tumor of the kidney characterized by the presence of blastema, epithelial, and mesenchymal components (triphasic pattern) or a combination of two of them (biphasic pattern). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed cell type kidney Wilms tumor

Professional guidelines

PubMed

Perioperative management after high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell transplantation for pediatric solid tumors.
Uehara S, Oue T, Nakahata K, Nara K, Ueno T, Owari M, Usui N, Miyamura T, Hashii Y
Eur J Pediatr Surg 2015 Feb;25(1):118-22. Epub 2014 Aug 11 doi: 10.1055/s-0034-1386638. PMID: 25111275
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Somatic-type Malignancies in Testicular Germ Cell Tumors: A Clinicopathologic Study of 63 Cases.
Hwang MJ, Hamza A, Zhang M, Tu SM, Pisters LL, Czerniak B, Guo CC
Am J Surg Pathol 2022 Jan 1;46(1):11-17. doi: 10.1097/PAS.0000000000001789. PMID: 34334690Free PMC Article
Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
Extensively cystic renal neoplasms in adults (Bosniak classification II or III)--possible "common" histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney.
Hora M, Hes O, Michal M, Boudová L, Chudácek Z, Kreuzberg B, Klecka J
Int Urol Nephrol 2005;37(4):743-50. doi: 10.1007/s11255-005-1201-5. PMID: 16362592
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Diagnosis

Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
Adult extrarenal Wilms' tumor mimicking mixed epithelial and stromal tumor in the retroperitoneum: a case report with immunohistochemical study and review of the literature.
Kadota K, Haba R, Kushida Y, Katsuki N, Hayashi T, Miyai Y, Bando K, Taoka R, Kakehi Y
Pathol Oncol Res 2009 Dec;15(4):665-9. Epub 2009 Apr 24 doi: 10.1007/s12253-009-9169-6. PMID: 19390992
Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum?
Argani P
Clin Lab Med 2005 Jun;25(2):379-92. doi: 10.1016/j.cll.2005.01.002. PMID: 15848742
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818
The evolution of the diagnosis and understanding of primitive and embryonic neoplasms in children: living through an epoch.
Dehner LP
Mod Pathol 1998 Jul;11(7):669-85. PMID: 9688189

Therapy

Decade-long WT1-specific CTLs induced by WT1 peptide vaccination.
Suwabe T, Shibasaki Y, Tamura S, Katagiri T, Fuse K, Ida-Kurasaki T, Ushiki T, Sone H, Narita M, Masuko M
Int J Hematol 2024 Apr;119(4):399-406. Epub 2024 Mar 1 doi: 10.1007/s12185-024-03723-1. PMID: 38427208
Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation.
Plantinga M, Lo Presti V, de Haar CG, Dünnebach E, Madrigal A, Lindemans CA, Boelens JJ, Nierkens S
Front Immunol 2020;11:559152. Epub 2020 Sep 25 doi: 10.3389/fimmu.2020.559152. PMID: 33101274Free PMC Article
Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells.
Coelho-Dos-Reis JG, Huang J, Tsao T, Pereira FV, Funakoshi R, Nakajima H, Sugiyama H, Tsuji M
Clin Immunol 2016 Jul;168:6-15. Epub 2016 Apr 27 doi: 10.1016/j.clim.2016.04.014. PMID: 27132023Free PMC Article
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Prognosis

CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor.
Xiang B, Chen ML, Gao ZQ, Mi T, Shi QL, Dong JJ, Tian XM, Liu F, Wei GH
BMC Med Genomics 2023 Aug 17;16(1):189. doi: 10.1186/s12920-023-01627-3. PMID: 37592341Free PMC Article
Somatic-type Malignancies in Testicular Germ Cell Tumors: A Clinicopathologic Study of 63 Cases.
Hwang MJ, Hamza A, Zhang M, Tu SM, Pisters LL, Czerniak B, Guo CC
Am J Surg Pathol 2022 Jan 1;46(1):11-17. doi: 10.1097/PAS.0000000000001789. PMID: 34334690Free PMC Article
Expression and prognostic value of the Ki-67 in Wilms' tumor: experience with 48 cases.
Jurić I, Pogorelić Z, Kuzmić-Prusac I, Biocić M, Jakovljević G, Stepan J, Zupancić B, Culić S, Kruslin B
Pediatr Surg Int 2010 May;26(5):487-93. Epub 2010 Mar 20 doi: 10.1007/s00383-010-2588-3. PMID: 20306058
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
The evolution of the diagnosis and understanding of primitive and embryonic neoplasms in children: living through an epoch.
Dehner LP
Mod Pathol 1998 Jul;11(7):669-85. PMID: 9688189

Clinical prediction guides

CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor.
Xiang B, Chen ML, Gao ZQ, Mi T, Shi QL, Dong JJ, Tian XM, Liu F, Wei GH
BMC Med Genomics 2023 Aug 17;16(1):189. doi: 10.1186/s12920-023-01627-3. PMID: 37592341Free PMC Article
Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms.
Ohishi Y, Oda Y, Kurihara S, Kaku T, Yasunaga M, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M
Hum Pathol 2009 Aug;40(8):1168-75. Epub 2009 Apr 14 doi: 10.1016/j.humpath.2009.01.002. PMID: 19368953
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms' tumor.
Karth J, Ferrer FA, Perlman E, Hanrahan C, Simons JW, Gearhart JP, Rodriguez R
J Pediatr Surg 2000 Dec;35(12):1749-53. doi: 10.1053/jpsu.2000.19241. PMID: 11101729
Pathological relevance of epithelial and mesenchymal phenotype plasticity.
Guarino M, Micheli P, Pallotti F, Giordano F
Pathol Res Pract 1999;195(6):379-89. doi: 10.1016/S0344-0338(99)80011-9. PMID: 10399178

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