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Prostate intraepithelial neoplasia

MedGen UID:
76480
•Concept ID:
C0282612
•
Neoplastic Process
Synonyms: Intraepithelial Neoplasia, Prostatic; Intraepithelial Neoplasm, Prostatic; Intraepithelial Neoplasms, Prostatic; Intraepithelial Prostatic Neoplasia; Intraepithelial Prostatic Neoplasias; Neoplasia, Intraepithelial Prostatic; Neoplasia, Prostatic Intraepithelial; Neoplasm, Prostatic Intraepithelial; Neoplasms, Prostatic Intraepithelial; Prostatic Intraepithelial Neoplasia; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasm; Prostatic Intraepithelial Neoplasms; Prostatic Neoplasia, Intraepithelial
SNOMED CT: PIN - Prostatic intraepithelial neoplasia (254901000); Prostatic intraepithelial neoplasia (254901000)
 
Monarch Initiative: MONDO:0005193

Definition

A neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade. [from NCI]

Professional guidelines

PubMed

Diet and prostate cancer - a holistic approach to management.
Cheetham PJ, Katz AE
Arch Esp Urol 2011 Oct;64(8):720-34. PMID: 22052755
Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia.
Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP
Urol Oncol 2005 Nov-Dec;23(6):383-5. doi: 10.1016/j.urolonc.2005.05.012. PMID: 16301113
Validity of primary care patient self-report of abnormal (but not cancer) prostate biopsy results.
McNaughton-Collins M, Barry MJ, Caubet JF, Bates DW, Lee JM, Hauser A, Fowler FJ Jr
J Urol 2004 Dec;172(6 Pt 1):2366-8. doi: 10.1097/01.ju.0000145178.29852.7b. PMID: 15538269

Recent clinical studies

Etiology

DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL EXPRESSION OF KI!67, P63 AND AMACR IN PROSTATE INTRAEPITHELIAL NEOPLASIA.
Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
PROGNOSTIC SIGNIFICANCE OF MAGNETIC RESONANCE IMAGING IN PATIENTS WITH PROSTATE INTRAEPITHELIAL NEOPLASIA.
Мelnychuk MP
Wiad Lek 2021;74(1):35-38. PMID: 33851583
Macrophages expedite cell proliferation of prostate intraepithelial neoplasia through their downstream target ERK.
Thomas MU, Messex JK, Dang T, Abdulkadir SA, Jorcyk CL, Liou GY
FEBS J 2021 Mar;288(6):1871-1886. Epub 2020 Sep 25 doi: 10.1111/febs.15541. PMID: 32865335Free PMC Article
Diet and prostate cancer - a holistic approach to management.
Cheetham PJ, Katz AE
Arch Esp Urol 2011 Oct;64(8):720-34. PMID: 22052755
Prostate carcinogenesis and inflammation: emerging insights.
Palapattu GS, Sutcliffe S, Bastian PJ, Platz EA, De Marzo AM, Isaacs WB, Nelson WG
Carcinogenesis 2005 Jul;26(7):1170-81. Epub 2004 Oct 21 doi: 10.1093/carcin/bgh317. PMID: 15498784

Diagnosis

DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL EXPRESSION OF KI!67, P63 AND AMACR IN PROSTATE INTRAEPITHELIAL NEOPLASIA.
Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
The place of prostate rebiopsy in the diagnosis of prostate cancer.
Vida OÁ, Pricop C, Loghin A, Chiuţu LC, Mártha O
Rom J Morphol Embryol 2014;55(3 Suppl):1161-6. PMID: 25607400
Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents.
Khamis ZI, Iczkowski KA, Sang QX
Med Res Rev 2012 Sep;32(5):1026-77. Epub 2011 Jan 16 doi: 10.1002/med.20232. PMID: 22886631
Prostate carcinogenesis and inflammation: emerging insights.
Palapattu GS, Sutcliffe S, Bastian PJ, Platz EA, De Marzo AM, Isaacs WB, Nelson WG
Carcinogenesis 2005 Jul;26(7):1170-81. Epub 2004 Oct 21 doi: 10.1093/carcin/bgh317. PMID: 15498784
Prostatic specific antigen.
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Therapy

The Effect of Green Tea Consumption on Prostate Cancer Risk and Progression: A Systematic Review.
Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319
PIM1 kinase as a target in prostate cancer: roles in tumorigenesis, castration resistance, and docetaxel resistance.
Holder SL, Abdulkadir SA
Curr Cancer Drug Targets 2014;14(2):105-14. doi: 10.2174/1568009613666131126113854. PMID: 24274399
Diet and prostate cancer - a holistic approach to management.
Cheetham PJ, Katz AE
Arch Esp Urol 2011 Oct;64(8):720-34. PMID: 22052755
Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy.
Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA
Expert Opin Investig Drugs 2006 Mar;15(3):293-305. doi: 10.1517/13543784.15.3.293. PMID: 16503765
Chemoprevention for prostatic intraepithelial neoplasia.
Nelson PS, Gleason TP, Brawer MK
Eur Urol 1996;30(2):269-78. doi: 10.1159/000474180. PMID: 8875211

Prognosis

PROGNOSTIC SIGNIFICANCE OF MAGNETIC RESONANCE IMAGING IN PATIENTS WITH PROSTATE INTRAEPITHELIAL NEOPLASIA.
Мelnychuk MP
Wiad Lek 2021;74(1):35-38. PMID: 33851583
PreImplantation Factor immunohistochemical expression correlates with prostate cancer aggressiveness.
Raspollini MR, Montagnani I, Cirri P, Baroni G, Cimadamore A, Scarpelli M, Cheng L, Lopez-Beltran A, Montironi R, Barnea ER
Int J Biol Markers 2020 Jun;35(2):82-90. Epub 2020 May 11 doi: 10.1177/1724600820919969. PMID: 32389051
Repeat prostate biopsies following diagnoses of prostate intraepithelial neoplasia and atypical small gland proliferation.
Leite KR, Mitteldorf CA, Camara-Lopes LH
Int Braz J Urol 2005 Mar-Apr;31(2):131-6. doi: 10.1590/s1677-55382005000200007. PMID: 15877832
High-grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer.
Alcaraz A, Barranco MA, Corral JM, Ribal MJ, Carrió A, Mallofré C, Llopis J, Cetina A, Alvarez-Vijande R
Prostate 2001 Apr;47(1):29-35. doi: 10.1002/pros.1044. PMID: 11304727
Prostatic specific antigen.
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Clinical prediction guides

DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL EXPRESSION OF KI!67, P63 AND AMACR IN PROSTATE INTRAEPITHELIAL NEOPLASIA.
Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread.
Sigorski D, Wesołowski W, Gruszecka A, Gulczyński J, Zieliński P, Misiukiewicz S, Kitlińska J, Iżycka-Świeszewska E
J Cancer Res Clin Oncol 2023 Aug;149(9):5803-5822. Epub 2022 Dec 30 doi: 10.1007/s00432-022-04540-x. PMID: 36583743Free PMC Article
PreImplantation Factor immunohistochemical expression correlates with prostate cancer aggressiveness.
Raspollini MR, Montagnani I, Cirri P, Baroni G, Cimadamore A, Scarpelli M, Cheng L, Lopez-Beltran A, Montironi R, Barnea ER
Int J Biol Markers 2020 Jun;35(2):82-90. Epub 2020 May 11 doi: 10.1177/1724600820919969. PMID: 32389051
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.
Pascal LE, Masoodi KZ, Liu J, Qiu X, Song Q, Wang Y, Zang Y, Yang T, Wang Y, Rigatti LH, Chandran U, Colli LM, Vencio RZN, Lu Y, Zhang J, Wang Z
J Endocrinol 2017 Nov;235(2):123-136. doi: 10.1530/JOE-17-0112. PMID: 28870994Free PMC Article
Prostatic specific antigen.
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Recent systematic reviews

The Effect of Green Tea Consumption on Prostate Cancer Risk and Progression: A Systematic Review.
Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319

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