U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Postnatal Drug Withdrawal

MedGen UID:
769745
•Concept ID:
C3641105
•
Mental or Behavioral Dysfunction

Definition

Withdrawal signs and symptoms that present during the postnatal period and are caused by drug use by the pregnant mother. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostnatal Drug Withdrawal

Professional guidelines

PubMed

A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome.
van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T
Pharmacol Ther 2022 Jun;234:108045. Epub 2021 Nov 20 doi: 10.1016/j.pharmthera.2021.108045. PMID: 34813863
Management of the newborn infant affected by maternal opiates and other drugs of dependency.
Oei J, Lui K
J Paediatr Child Health 2007 Jan-Feb;43(1-2):9-18. doi: 10.1111/j.1440-1754.2007.00994.x. PMID: 17207049
Fluoxetine: a suitable long-term treatment.
Calil HM
J Clin Psychiatry 2001;62 Suppl 22:24-9. PMID: 11599644

Recent clinical studies

Etiology

Surveillance, Epidemiology, and Estimated Burden of Neonatal Abstinence Syndrome, Tennessee, 2013-2016.
Brennan J, Wiedeman C, Dunn JR, Schaffner W, Jones TF
Public Health Rep 2019 Sep/Oct;134(5):537-541. Epub 2019 Aug 7 doi: 10.1177/0033354919867718. PMID: 31390300Free PMC Article
Educational Disabilities Among Children Born With Neonatal Abstinence Syndrome.
Fill MA, Miller AM, Wilkinson RH, Warren MD, Dunn JR, Schaffner W, Jones TF
Pediatrics 2018 Sep;142(3) doi: 10.1542/peds.2018-0562. PMID: 30166364Free PMC Article
Improving Care for Neonatal Abstinence Syndrome.
Patrick SW, Schumacher RE, Horbar JD, Buus-Frank ME, Edwards EM, Morrow KA, Ferrelli KR, Picarillo AP, Gupta M, Soll RF
Pediatrics 2016 May;137(5) Epub 2016 Apr 15 doi: 10.1542/peds.2015-3835. PMID: 27244809Free PMC Article
Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Diagnosis

Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Prognosis

Born Into Addiction: Neonatal Abstinence Syndrome and Pediatric Dentistry.
Cully JL
Pediatr Dent 2017 Sep 15;39(5):358-360. PMID: 29070156
Incidence of Neonatal Abstinence Syndrome - 28 States, 1999-2013.
Ko JY, Patrick SW, Tong VT, Patel R, Lind JN, Barfield WD
MMWR Morb Mortal Wkly Rep 2016 Aug 12;65(31):799-802. doi: 10.15585/mmwr.mm6531a2. PMID: 27513154
Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Clinical prediction guides

Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...