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Metastatic Malignant Neoplasm in the Ovary

MedGen UID:
777081
•Concept ID:
C3647143
•
Neoplastic Process
Synonyms: Cancer metastatic to ovary; Metastases to Ovary; Metastasis to ovary; Metastasis to Ovary; Metastatic malignant neoplasm of ovary; Metastatic malignant neoplasm to ovary; Metastatic Malignant Neoplasm to the Ovary; Metastatic Malignant Tumor to the Ovary; Ovarian metastasis; Ovarian Metastasis; Secondary cancer of ovary; Secondary malignant neoplasm of ovary; Secondary tumor to ovary
SNOMED CT: Secondary malignant neoplasm of ovary (94455000); Metastatic malignant neoplasm to ovary (94455000); Cancer metastatic to ovary (94455000); Metastatic malignant neoplasm of ovary (94455000); Secondary tumor to ovary (94455000); Ovarian metastasis (94455000); Metastasis to ovary (94455000); Secondary cancer of ovary (94455000)

Definition

The spread of a malignant neoplasm to the ovary. This may be from a primary ovarian malignant neoplasm involving the opposite ovary, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Ovary

Professional guidelines

PubMed

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
Childhood Obesity: Causes, Consequences, and Management.
Gurnani M, Birken C, Hamilton J
Pediatr Clin North Am 2015 Aug;62(4):821-40. Epub 2015 May 23 doi: 10.1016/j.pcl.2015.04.001. PMID: 26210619
Amenorrhea: an approach to diagnosis and management.
Klein DA, Poth MA
Am Fam Physician 2013 Jun 1;87(11):781-8. PMID: 23939500

Recent clinical studies

Etiology

Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor-Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial.
Baek SY, Noh WC, Ahn SH, Kim HA, Ryu JM, Kim SI, Lee EG, Im SA, Jung Y, Park MH, Park KH, Kang SH, Jeong J, Park E, Kim SY, Lee MH, Kim LS, Lim W, Kim S, Kim HJ
J Clin Oncol 2023 Nov 1;41(31):4864-4871. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00557. PMID: 37607321
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article
Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.
Lambertini M, Moore HCF, Leonard RCF, Loibl S, Munster P, Bruzzone M, Boni L, Unger JM, Anderson RA, Mehta K, Minton S, Poggio F, Albain KS, Adamson DJA, Gerber B, Cripps A, Bertelli G, Seiler S, Ceppi M, Partridge AH, Del Mastro L
J Clin Oncol 2018 Jul 1;36(19):1981-1990. Epub 2018 May 2 doi: 10.1200/JCO.2018.78.0858. PMID: 29718793Free PMC Article
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Diagnosis

Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Fallopian Tubes Take Center Stage with the Ovary.
Kho RM
J Minim Invasive Gynecol 2017 Feb;24(2):181. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.019. PMID: 28027974
Mucinous tumours of the ovary--primary and metastatic.
Heatley MK
J Clin Pathol 2012 Jul;65(7):577-9. Epub 2011 Nov 12 doi: 10.1136/jclinpath-2011-200407. PMID: 22081785
Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms.
McCluggage WG
J Clin Pathol 2012 Jul;65(7):596-600. Epub 2011 Jul 18 doi: 10.1136/jcp.2010.085688. PMID: 21768188

Therapy

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis.
Ma Q, He X, Zhang B, Guo F, Ou X, Yang Q, Shu P, Chen Y, Li K, Gao G, Zhu Y, Qin D, Tang J, Li X, Jing M, Zhao J, Mo Z, Liu N, Zeng Y, Zhou K, Feng M, Liao W, Lei W, Li Q, Li D, Wang Y
Signal Transduct Target Ther 2022 Nov 19;7(1):380. doi: 10.1038/s41392-022-01198-2. PMID: 36402752Free PMC Article
Acupuncture for polycystic ovarian syndrome.
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Lifestyle changes in women with polycystic ovary syndrome.
Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ
Cochrane Database Syst Rev 2019 Mar 28;3(3):CD007506. doi: 10.1002/14651858.CD007506.pub4. PMID: 30921477Free PMC Article
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article

Prognosis

Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor-Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial.
Baek SY, Noh WC, Ahn SH, Kim HA, Ryu JM, Kim SI, Lee EG, Im SA, Jung Y, Park MH, Park KH, Kang SH, Jeong J, Park E, Kim SY, Lee MH, Kim LS, Lim W, Kim S, Kim HJ
J Clin Oncol 2023 Nov 1;41(31):4864-4871. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00557. PMID: 37607321
Pan-cancer analysis of prognostic metastatic phenotypes.
Zaorsky NG, Wang X, Garrett SM, Lehrer EJ, Lin C, DeGraff DJ, Spratt DE, Trifiletti DM, Kishan AU, Showalter TN, Park HS, Yang JT, Chinchilli VM, Wang M
Int J Cancer 2022 Jan 1;150(1):132-141. Epub 2021 Aug 27 doi: 10.1002/ijc.33744. PMID: 34287840Free PMC Article
Unusual cutaneous metastatic carcinoma.
Ruiz SJ, Al Salihi S, Prieto VG, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Torres-Cabala CA, Aung PP
Ann Diagn Pathol 2019 Dec;43:151399. Epub 2019 Aug 12 doi: 10.1016/j.anndiagpath.2019.08.003. PMID: 31675677
Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073

Clinical prediction guides

Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.
Lambertini M, Moore HCF, Leonard RCF, Loibl S, Munster P, Bruzzone M, Boni L, Unger JM, Anderson RA, Mehta K, Minton S, Poggio F, Albain KS, Adamson DJA, Gerber B, Cripps A, Bertelli G, Seiler S, Ceppi M, Partridge AH, Del Mastro L
J Clin Oncol 2018 Jul 1;36(19):1981-1990. Epub 2018 May 2 doi: 10.1200/JCO.2018.78.0858. PMID: 29718793Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Case 225: Leiomyoma.
DiPoce J, Liu-Jarin X, Newhouse J
Radiology 2016 Jan;278(1):297-301. doi: 10.1148/radiol.2015130251. PMID: 26690995
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women.
Kazemi M, Kim JY, Wan C, Xiong JD, Michalak J, Xavier IB, Ganga K, Tay CT, Grieger JA, Parry SA, Moran LJ, Lujan ME
Hum Reprod Update 2022 Nov 2;28(6):910-955. doi: 10.1093/humupd/dmac023. PMID: 35639552Free PMC Article
Acupuncture for polycystic ovarian syndrome.
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Lifestyle changes in women with polycystic ovary syndrome.
Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ
Cochrane Database Syst Rev 2019 Mar 28;3(3):CD007506. doi: 10.1002/14651858.CD007506.pub4. PMID: 30921477Free PMC Article
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C
Cochrane Database Syst Rev 2018 May 24;5(5):CD010287. doi: 10.1002/14651858.CD010287.pub3. PMID: 29797697Free PMC Article

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