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Fetal anticonvulsant syndrome

MedGen UID:
781143
•Concept ID:
C1739111
•
Disease or Syndrome
Synonyms: FACS; Fetal AEDS; Fetal antiepileptic drug syndrome; Fetal disorder caused by anticonvulsant via placental transfer; Fetus affected by placental transfer of anticonvulsant; Foetal anticonvulsant syndrome; Foetus affected by placental transfer of anticonvulsant
SNOMED CT: Fetal disorder caused by anticonvulsant via placental transfer (429211000124107); Fetus affected by placental transfer of anticonvulsant (429211000124107); Foetus affected by placental transfer of anticonvulsant (429211000124107); Fetal anticonvulsant syndrome (429211000124107); Foetal anticonvulsant syndrome (429211000124107)
 
Orphanet: ORPHA370068

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal anticonvulsant syndrome

Professional guidelines

PubMed

Developing diagnostic criteria for the fetal anticonvulsant syndromes.
Dean JC, Moore SJ, Turnpenny PD
Seizure 2000 Apr;9(3):233-4. doi: 10.1053/seiz.2000.0392. PMID: 10775521

Recent clinical studies

Etiology

Fetal valproate syndrome: the Irish experience.
Mohd Yunos H, Green A
Ir J Med Sci 2018 Nov;187(4):965-968. Epub 2018 Feb 3 doi: 10.1007/s11845-018-1757-6. PMID: 29396778
The importance of monotherapy in pregnancy.
Pennell PB
Neurology 2003 Jun 10;60(11 Suppl 4):S31-8. doi: 10.1212/wnl.60.11_suppl_4.s31. PMID: 12796519
Pregnancy in the woman with epilepsy: maternal and fetal outcomes.
Pennell PB
Semin Neurol 2002 Sep;22(3):299-308. doi: 10.1055/s-2002-36649. PMID: 12528055
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD
Ophthalmology 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. PMID: 11986102
Fetal anticonvulsant syndrome and mutation in the maternal MTHFR gene.
Dean JC, Moore SJ, Osborne A, Howe J, Turnpenny PD
Clin Genet 1999 Sep;56(3):216-20. doi: 10.1034/j.1399-0004.1999.560306.x. PMID: 10563481

Diagnosis

Intellectual functioning in clinically confirmed fetal valproate syndrome.
Bromley RL, Baker GA, Clayton-Smith J, Wood AG
Neurotoxicol Teratol 2019 Jan-Feb;71:16-21. Epub 2018 Nov 16 doi: 10.1016/j.ntt.2018.11.003. PMID: 30453023
Fetal valproate syndrome: the Irish experience.
Mohd Yunos H, Green A
Ir J Med Sci 2018 Nov;187(4):965-968. Epub 2018 Feb 3 doi: 10.1007/s11845-018-1757-6. PMID: 29396778
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J; Liverpool and Manchester Neurodevelopmental Study Group
Arch Dis Child Fetal Neonatal Ed 2006 Mar;91(2):F90-5. Epub 2005 Oct 20 doi: 10.1136/adc.2004.067421. PMID: 16239295Free PMC Article
Characteristics of fetal anticonvulsant syndrome associated autistic disorder.
Rasalam AD, Hailey H, Williams JH, Moore SJ, Turnpenny PD, Lloyd DJ, Dean JC
Dev Med Child Neurol 2005 Aug;47(8):551-5. doi: 10.1017/s0012162205001076. PMID: 16108456
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD
Ophthalmology 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. PMID: 11986102

Therapy

Fetal valproate syndrome: the Irish experience.
Mohd Yunos H, Green A
Ir J Med Sci 2018 Nov;187(4):965-968. Epub 2018 Feb 3 doi: 10.1007/s11845-018-1757-6. PMID: 29396778
The importance of monotherapy in pregnancy.
Pennell PB
Neurology 2003 Jun 10;60(11 Suppl 4):S31-8. doi: 10.1212/wnl.60.11_suppl_4.s31. PMID: 12796519
Pregnancy in the woman with epilepsy: maternal and fetal outcomes.
Pennell PB
Semin Neurol 2002 Sep;22(3):299-308. doi: 10.1055/s-2002-36649. PMID: 12528055
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD
Ophthalmology 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. PMID: 11986102
Fetal anticonvulsant syndrome and mutation in the maternal MTHFR gene.
Dean JC, Moore SJ, Osborne A, Howe J, Turnpenny PD
Clin Genet 1999 Sep;56(3):216-20. doi: 10.1034/j.1399-0004.1999.560306.x. PMID: 10563481

Prognosis

Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations.
Kinney MO, Morrow J, Patterson CC, Campbell E, Russell A, Smithson HW, Parsons L, Morrison PJ, Bromley R, Liggan B, Delanty N, Irwin B, Hunt SJ, Craig JJ
J Neurol Neurosurg Psychiatry 2018 Dec;89(12):1320-1323. Epub 2018 Apr 16 doi: 10.1136/jnnp-2017-317368. PMID: 29661925
Development of a core outcome set for epilepsy in pregnancy (E-CORE): a national multi-stakeholder modified Delphi consensus study.
Al Wattar BH, Tamilselvan K, Khan R, Kelso A, Sinha A, Pirie AM, McCorry D, Khan KS, Thangaratinam S; Antiepileptic Drug Management in Pregnancy (EMPIRE) Collaborative Network
BJOG 2017 Mar;124(4):661-667. Epub 2016 Nov 16 doi: 10.1111/1471-0528.14430. PMID: 27860117
Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years.
Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study Group
JAMA Pediatr 2014 Aug;168(8):729-36. doi: 10.1001/jamapediatrics.2014.118. PMID: 24934501Free PMC Article
Intracranial arteriovenous malformation with maternal carbamazepine use.
Narang M, Shah D, Natasha G
Indian J Pediatr 2007 Jan;74(1):85-6. doi: 10.1007/s12098-007-0035-9. PMID: 17264463

Clinical prediction guides

Intellectual functioning in clinically confirmed fetal valproate syndrome.
Bromley RL, Baker GA, Clayton-Smith J, Wood AG
Neurotoxicol Teratol 2019 Jan-Feb;71:16-21. Epub 2018 Nov 16 doi: 10.1016/j.ntt.2018.11.003. PMID: 30453023
Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations.
Kinney MO, Morrow J, Patterson CC, Campbell E, Russell A, Smithson HW, Parsons L, Morrison PJ, Bromley R, Liggan B, Delanty N, Irwin B, Hunt SJ, Craig JJ
J Neurol Neurosurg Psychiatry 2018 Dec;89(12):1320-1323. Epub 2018 Apr 16 doi: 10.1136/jnnp-2017-317368. PMID: 29661925
Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort.
Charlton RA, McGrogan A, Snowball J, Yates LM, Wood A, Clayton-Smith J, Smithson WH, Richardson JL, McHugh N, Thomas SH, Baker GA, Bromley R
Drug Saf 2017 May;40(5):387-397. doi: 10.1007/s40264-017-0506-5. PMID: 28188601Free PMC Article
Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study.
Mawer G, Briggs M, Baker GA, Bromley R, Coyle H, Eatock J, Kerr L, Kini U, Kuzmyshcheva L, Lucas SB, Wyatt L, Clayton-Smith J; Liverpool & Manchester Neurodevelopment Group
Seizure 2010 Mar;19(2):112-9. Epub 2009 Dec 24 doi: 10.1016/j.seizure.2009.11.008. PMID: 20036166Free PMC Article
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD
Ophthalmology 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. PMID: 11986102

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