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Neonatal polycythemia

MedGen UID:
78794
•Concept ID:
C0272153
•
Disease or Syndrome
Synonym: Polycythemia neonatorum
SNOMED CT: Polycythemia neonatorum (32984002); Plethora of newborn (32984002); Neonatal polycythemia (32984002)
 
Monarch Initiative: MONDO:0001238

Definition

A condition in which the red blood cell level is greater than established reference ranges in a newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal polycythemia

Professional guidelines

PubMed

Differential diagnosis and management of polycythemia.
Pappas A, Delaney-Black V
Pediatr Clin North Am 2004 Aug;51(4):1063-86, x-xi. doi: 10.1016/j.pcl.2004.03.012. PMID: 15275989
Neonatal polycythemia.
Armentrout DC, Huseby V; Department of Pediatrics, University of Texas-Houston Medical School USA
J Pediatr Health Care 2002 Jan-Feb;16(1):40-2. PMID: 11802122
Neonatal polycythemia: I. Criteria for diagnosis and treatment.
Ramamurthy RS, Brans YW
Pediatrics 1981 Aug;68(2):168-74. PMID: 7267222

Recent clinical studies

Etiology

Neonatal polycythemia: prevalence, risk factors and predictors of severity.
Martins AS, Flor-DE-Lima F, Rocha G, Soares P, Machado AP, Guimarães MH
Minerva Pediatr (Torino) 2024 Feb;76(1):64-71. doi: 10.23736/S2724-5276.21.05851-1. PMID: 38376233
Neonatal Polycythemia and Hypoglycemia in Newborns: Are They Related?
Hopfeld-Fogel A, Kasirer Y, Mimouni FB, Hammerman C, Bin-Nun A
Am J Perinatol 2021 Jul;38(9):930-934. Epub 2020 Feb 6 doi: 10.1055/s-0040-1701193. PMID: 32028531
Neonatal polycythemia and hyperviscosity.
Sarkar S, Rosenkrantz TS
Semin Fetal Neonatal Med 2008 Aug;13(4):248-55. doi: 10.1016/j.siny.2008.02.003. PMID: 18424246
Neonatal polycythemia.
Krishnan L, Rahim A
Indian J Pediatr 1997 Jul-Aug;64(4):541-6. doi: 10.1007/BF02737765. PMID: 10771885
Neonatal polycythemia and hyperviscosity.
Werner EJ
Clin Perinatol 1995 Sep;22(3):693-710. PMID: 8521689

Diagnosis

Neonatal polycythemia: prevalence, risk factors and predictors of severity.
Martins AS, Flor-DE-Lima F, Rocha G, Soares P, Machado AP, Guimarães MH
Minerva Pediatr (Torino) 2024 Feb;76(1):64-71. doi: 10.23736/S2724-5276.21.05851-1. PMID: 38376233
Neonatal polycythemia and hyperviscosity.
Sarkar S, Rosenkrantz TS
Semin Fetal Neonatal Med 2008 Aug;13(4):248-55. doi: 10.1016/j.siny.2008.02.003. PMID: 18424246
Differential diagnosis and management of polycythemia.
Pappas A, Delaney-Black V
Pediatr Clin North Am 2004 Aug;51(4):1063-86, x-xi. doi: 10.1016/j.pcl.2004.03.012. PMID: 15275989
Neonatal polycythemia.
Krishnan L, Rahim A
Indian J Pediatr 1997 Jul-Aug;64(4):541-6. doi: 10.1007/BF02737765. PMID: 10771885
Neonatal polycythemia: I. Criteria for diagnosis and treatment.
Ramamurthy RS, Brans YW
Pediatrics 1981 Aug;68(2):168-74. PMID: 7267222

Therapy

Restrictive management of neonatal polycythemia.
Morag I, Strauss T, Lubin D, Schushan-Eisen I, Kenet G, Kuint J
Am J Perinatol 2011 Oct;28(9):677-82. Epub 2011 Jun 10 doi: 10.1055/s-0031-1280595. PMID: 21667428
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis.
Dempsey EM, Barrington K
Acta Paediatr 2005 Nov;94(11):1650-5. doi: 10.1080/08035250500192748. PMID: 16303705
Neonatal polycythemia.
Krishnan L, Rahim A
Indian J Pediatr 1997 Jul-Aug;64(4):541-6. doi: 10.1007/BF02737765. PMID: 10771885
Neonatal polycythemia and hyperviscosity.
Oh W
Pediatr Clin North Am 1986 Jun;33(3):523-32. doi: 10.1016/s0031-3955(16)36040-0. PMID: 3714337
Neonatal polycythemia.
Schussman LC, Wright ST
Am Fam Physician 1984 Feb;29(2):111-7. PMID: 6702518

Prognosis

Neonatal polycythemia: prevalence, risk factors and predictors of severity.
Martins AS, Flor-DE-Lima F, Rocha G, Soares P, Machado AP, Guimarães MH
Minerva Pediatr (Torino) 2024 Feb;76(1):64-71. doi: 10.23736/S2724-5276.21.05851-1. PMID: 38376233
Utilizing umbilical cord blood - Minimizing blood sampling and pain in healthy infants at risk for polycythemia.
Zaitoon H, Riskin A, Hemo M, Toropine A, Gover A
Early Hum Dev 2022 May;168:105573. Epub 2022 Apr 20 doi: 10.1016/j.earlhumdev.2022.105573. PMID: 35468574
Polycythemia in the newborn.
Armentrout DC, Huseby V
MCN Am J Matern Child Nurs 2003 Jul-Aug;28(4):234-9; quiz 240-1. doi: 10.1097/00005721-200307000-00004. PMID: 12840689
Neonatal polycythemia.
Krishnan L, Rahim A
Indian J Pediatr 1997 Jul-Aug;64(4):541-6. doi: 10.1007/BF02737765. PMID: 10771885
Neonatal polycythemia and hyperviscosity.
Oh W
Pediatr Clin North Am 1986 Jun;33(3):523-32. doi: 10.1016/s0031-3955(16)36040-0. PMID: 3714337

Clinical prediction guides

Neonatal polycythemia: prevalence, risk factors and predictors of severity.
Martins AS, Flor-DE-Lima F, Rocha G, Soares P, Machado AP, Guimarães MH
Minerva Pediatr (Torino) 2024 Feb;76(1):64-71. doi: 10.23736/S2724-5276.21.05851-1. PMID: 38376233
Utilizing umbilical cord blood - Minimizing blood sampling and pain in healthy infants at risk for polycythemia.
Zaitoon H, Riskin A, Hemo M, Toropine A, Gover A
Early Hum Dev 2022 May;168:105573. Epub 2022 Apr 20 doi: 10.1016/j.earlhumdev.2022.105573. PMID: 35468574
Management of the insulin-dependent diabetic during labor and delivery. Influences on neonatal outcome.
Miodovnik M, Mimouni F, Tsang RC, Skillman C, Siddiqi TA, Butler JB, Holroyde J
Am J Perinatol 1987 Apr;4(2):106-14. doi: 10.1055/s-2007-999750. PMID: 3551973
Erythropoiesis in infants of diabetic mothers.
Shannon K, Davis JC, Kitzmiller JL, Fulcher SA, Koenig HM
Pediatr Res 1986 Feb;20(2):161-5. doi: 10.1203/00006450-198602000-00014. PMID: 3945525
Neonatal polycythemia in infants of insulin-dependent diabetic mothers.
Mimouni F, Miodovnik M, Siddiqi TA, Butler JB, Holroyde J, Tsang RC
Obstet Gynecol 1986 Sep;68(3):370-2. doi: 10.1097/00006250-198609000-00016. PMID: 3737061

Recent systematic reviews

Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia.
Ozek E, Soll R, Schimmel MS
Cochrane Database Syst Rev 2010 Jan 20;(1):CD005089. doi: 10.1002/14651858.CD005089.pub2. PMID: 20091569
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis.
Dempsey EM, Barrington K
Acta Paediatr 2005 Nov;94(11):1650-5. doi: 10.1080/08035250500192748. PMID: 16303705

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