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Anaplasmosis

MedGen UID:: 8053
•Concept ID:: C0002797
•: Disease or Syndrome

Synonyms:	Anaplasma Infection; Anaplasma Infections; Anaplasma phagocytophilum Infection; Anaplasma phagocytophilum Infections; Anaplasmoses; Infection, Anaplasma; Infections, Anaplasma
SNOMED CT:	Anaplasmosis (13906002); Gallsickness (13906002)

Monarch Initiative:	MONDO:0025303

Definition

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAnaplasmosis

Finding by Cause
- Infection
  - Bacterial Infections and Mycoses
    - Bacterial infectious disease
      - Gram-negative bacterial infections
        Anaplasmataceae Infections
        Anaplasmosis

Professional guidelines

PubMed

Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome.

Kim DM, Yu BJ, Kim DY, Seo JW, Yun NR, Kim CM, Kim YK, Jung SI, Kim UJ, Kim SE, Kim HA, Kim ES, Hur J, Lee SH, Jeong HW, Heo JY, Jung DS, Kim J, Park SH, Kwak YG, Lee S, Lim S, Chatterjee S
Sci Rep 2023 Apr 26;13(1):6837. doi: 10.1038/s41598-023-32061-1. PMID: 37100782 Free PMC Article

Tickborne Diseases: Diagnosis and Management.

Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378 Free PMC Article

See all (26)

Recent clinical studies

Etiology

Human Granulocytic Anaplasmosis.

MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840

Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.

Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661 Free PMC Article

Tickborne Diseases: Diagnosis and Management.

Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736

The Blacklegged Tick, Ixodes scapularis: An Increasing Public Health Concern.

Eisen RJ, Eisen L
Trends Parasitol 2018 Apr;34(4):295-309. Epub 2018 Jan 11 doi: 10.1016/j.pt.2017.12.006. PMID: 29336985 Free PMC Article

Human granulocytic anaplasmosis.

Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228 Free PMC Article

See all (257)

Diagnosis

Human Granulocytic Anaplasmosis.

MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840

Tickborne Diseases: Diagnosis and Management.

Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736

Tick borne illness-Lyme disease.

Bush LM, Vazquez-Pertejo MT
Dis Mon 2018 May;64(5):195-212. doi: 10.1016/j.disamonth.2018.01.007. PMID: 29402399

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378 Free PMC Article

Tick-Borne Illnesses.

Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018

See all (292)

Therapy

Human Granulocytic Anaplasmosis.

MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840

Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.

Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661 Free PMC Article

Tickborne Diseases: Diagnosis and Management.

Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736

Tick borne illness-Lyme disease.

Bush LM, Vazquez-Pertejo MT
Dis Mon 2018 May;64(5):195-212. doi: 10.1016/j.disamonth.2018.01.007. PMID: 29402399

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378 Free PMC Article

See all (99)

Prognosis

Zoonotic Babesia: A scoping review of the global evidence.

Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120 Free PMC Article

Human Tick-Borne Diseases in Australia.

Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341 Free PMC Article

The Blacklegged Tick, Ixodes scapularis: An Increasing Public Health Concern.

Eisen RJ, Eisen L
Trends Parasitol 2018 Apr;34(4):295-309. Epub 2018 Jan 11 doi: 10.1016/j.pt.2017.12.006. PMID: 29336985 Free PMC Article

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378 Free PMC Article

Lyme Disease Coinfections in the United States.

Caulfield AJ, Pritt BS
Clin Lab Med 2015 Dec;35(4):827-46. Epub 2015 Sep 1 doi: 10.1016/j.cll.2015.07.006. PMID: 26593260

See all (106)

Clinical prediction guides

Zoonotic Babesia: A scoping review of the global evidence.

Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120 Free PMC Article

Human Tick-Borne Diseases in Australia.

Distribution of tick-borne diseases in China.

Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ
Parasit Vectors 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899 Free PMC Article

Clinical diagnosis and treatment of human granulocytotropic anaplasmosis.

Bakken JS, Dumler JS
Ann N Y Acad Sci 2006 Oct;1078:236-47. doi: 10.1196/annals.1374.042. PMID: 17114714

Coinfections acquired from ixodes ticks.

Swanson SJ, Neitzel D, Reed KD, Belongia EA
Clin Microbiol Rev 2006 Oct;19(4):708-27. doi: 10.1128/CMR.00011-06. PMID: 17041141 Free PMC Article

See all (105)

Recent systematic reviews

Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.

Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701 Free PMC Article

Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.

Fischhoff IR, Bowden SE, Keesing F, Ostfeld RS
BMC Infect Dis 2019 Oct 17;19(1):861. doi: 10.1186/s12879-019-4484-3. PMID: 31623574 Free PMC Article

Repellence of essential oils and selected compounds against ticks-A systematic review.

Benelli G, Pavela R
Acta Trop 2018 Mar;179:47-54. Epub 2017 Dec 26 doi: 10.1016/j.actatropica.2017.12.025. PMID: 29287758

Chronic coinfections in patients diagnosed with chronic lyme disease: a systematic review.

Lantos PM, Wormser GP
Am J Med 2014 Nov;127(11):1105-1110. Epub 2014 Jun 12 doi: 10.1016/j.amjmed.2014.05.036. PMID: 24929022 Free PMC Article

Epidemiology and control of human granulocytic anaplasmosis: a systematic review.

Jin H, Wei F, Liu Q, Qian J
Vector Borne Zoonotic Dis 2012 Apr;12(4):269-74. Epub 2012 Jan 4 doi: 10.1089/vbz.2011.0753. PMID: 22217177

See all (9)