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Follicular variant thyroid gland papillary carcinoma

MedGen UID:
811427
•Concept ID:
C3714651
•
Neoplastic Process
Synonyms: Follicular Variant Thyroid Gland Papillary Carcinoma; follicular variant thyroid gland papillary carcinoma; FVPTC
 
Monarch Initiative: MONDO:0006214

Definition

An encapsulated or nonencapsulated variant of papillary carcinoma of the thyroid gland characterized by the predominance of follicular structures. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFollicular variant thyroid gland papillary carcinoma

Professional guidelines

PubMed

Management of pediatric papillary thyroid cancer.
Pazaitou-Panayiotou K
Hell J Nucl Med 2023 May-Aug;26 Suppl:60-64. PMID: 37658567
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Management of the central compartment in differentiated thyroid carcinoma.
Goepfert RP, Clayman GL
Eur J Surg Oncol 2018 Mar;44(3):327-331. Epub 2017 Sep 13 doi: 10.1016/j.ejso.2017.09.004. PMID: 28964612

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Diagnosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Therapy

Target Therapy in Thyroid Cancer: Current Challenge in Clinical Use of Tyrosine Kinase Inhibitors and Management of Side Effects.
Puliafito I, Esposito F, Prestifilippo A, Marchisotta S, Sciacca D, Vitale MP, Giuffrida D
Front Endocrinol (Lausanne) 2022;13:860671. Epub 2022 Jul 8 doi: 10.3389/fendo.2022.860671. PMID: 35872981Free PMC Article
Cabozantinib for radioiodine-refractory differentiated thyroid cancer (COSMIC-311): a randomised, double-blind, placebo-controlled, phase 3 trial.
Brose MS, Robinson B, Sherman SI, Krajewska J, Lin CC, Vaisman F, Hoff AO, Hitre E, Bowles DW, Hernando J, Faoro L, Banerjee K, Oliver JW, Keam B, Capdevila J
Lancet Oncol 2021 Aug;22(8):1126-1138. Epub 2021 Jul 5 doi: 10.1016/S1470-2045(21)00332-6. PMID: 34237250
BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.
Al-Salam S, Sharma C, Afandi B, Al Dahmani K, Al-Zahrani AS, Al Shamsi A, Al Kaabi J
PLoS One 2020;15(4):e0231341. Epub 2020 Apr 21 doi: 10.1371/journal.pone.0231341. PMID: 32315324Free PMC Article
New Insights in Thyroid Cancer and p53 Family Proteins.
Manzella L, Stella S, Pennisi MS, Tirrò E, Massimino M, Romano C, Puma A, Tavarelli M, Vigneri P
Int J Mol Sci 2017 Jun 21;18(6) doi: 10.3390/ijms18061325. PMID: 28635633Free PMC Article
Infarction of papillary thyroid carcinoma after fine-needle aspiration: case series and review of literature.
Liu YF, Ahmed S, Bhuta S, Sercarz JA
JAMA Otolaryngol Head Neck Surg 2014 Jan;140(1):52-7. doi: 10.1001/jamaoto.2013.5650. PMID: 24232180

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
RAS-positive thyroid nodules.
Angell TE
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):372-376. doi: 10.1097/MED.0000000000000354. PMID: 28639967
The History of the Follicular Variant of Papillary Thyroid Carcinoma.
Tallini G, Tuttle RM, Ghossein RA
J Clin Endocrinol Metab 2017 Jan 1;102(1):15-22. doi: 10.1210/jc.2016-2976. PMID: 27732333
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Daniels GH
Thyroid 2016 Jul;26(7):872-4. Epub 2016 Jun 22 doi: 10.1089/thy.2016.0244. PMID: 27214083Free PMC Article

Clinical prediction guides

Molecular characterisation and clinical correlation of papillary thyroid microcarcinoma.
Samà MT, Grosso E, Mele C, Laurora S, Monzeglio O, Marzullo P, Boldorini R, Aluffi Valletti P, Aimaretti G, Scatolini M, Pagano L
Endocrine 2021 Jan;71(1):149-157. Epub 2020 Jul 3 doi: 10.1007/s12020-020-02380-8. PMID: 32621051
Molecular Profiling of Follicular Variant of Papillary Thyroid Cancer.
Spirina LV, Chizhevskaya SY, Kondakova IV
Bull Exp Biol Med 2020 May;169(1):85-88. Epub 2020 Jun 3 doi: 10.1007/s10517-020-04830-9. PMID: 32495172
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Daniels GH
Thyroid 2016 Jul;26(7):872-4. Epub 2016 Jun 22 doi: 10.1089/thy.2016.0244. PMID: 27214083Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Recent systematic reviews

Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis.
Haaga E, Kalfert D, Ludvíková M, Kholová I
Acta Cytol 2022;66(2):85-105. Epub 2021 Nov 15 doi: 10.1159/000519757. PMID: 34781293Free PMC Article
Pathological findings of the retrospective diagnosis of NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) in 84 cases from Turkey and systematic review.
Turan G, Özkara SK
Ann Diagn Pathol 2021 Aug;53:151764. Epub 2021 Jun 9 doi: 10.1016/j.anndiagpath.2021.151764. PMID: 34118581
Systematic Review and Meta-analysis of the Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Cytological Diagnosis and Thyroid Cancer Prevalence.
Ruanpeng D, Cheungpasitporn W, Thongprayoon C, Hennessey JV, Shrestha RT
Endocr Pathol 2019 Sep;30(3):189-200. doi: 10.1007/s12022-019-09583-4. PMID: 31338752
Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis.
Bongiovanni M, Giovanella L, Romanelli F, Trimboli P
Thyroid 2019 Feb;29(2):222-228. Epub 2018 Dec 21 doi: 10.1089/thy.2018.0394. PMID: 30426887
Thyroid Cancer: 20-Year Comparative Mortality and Survival Analysis of Six Thyroid Cancer Histologic Subtypes by Age, Sex, Race, Stage, Cohort Entry Time-Period and Disease Duration (SEER*Stat 8.3.2) A Systematic Review of 145,457 Cases for Diagnosis Years 1993-2013.
Milano AF
J Insur Med 2018 Jan;47(3):143-158. doi: 10.17849/insm-47-03-143-158.1. PMID: 30192723

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