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Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

MedGen UID:
819638
•Concept ID:
C3826890
•
Neoplastic Process
Synonyms: Pancreatic BD-IPMN; Pancreatic SB-IPMN; Side Branch Pancreatic Intraductal Papillary-Mucinous Neoplasm

Definition

An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct. It usually has an indolent behavior. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBranch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

Professional guidelines

PubMed

Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm.
Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ
Clin Gastroenterol Hepatol 2008 Jul;6(7):815-9; quiz 719. doi: 10.1016/j.cgh.2008.04.005. PMID: 18602036

Recent clinical studies

Etiology

Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation.
Marchegiani G, Pollini T, Burelli A, Han Y, Jung HS, Kwon W, Rocha Castellanos DM, Crippa S, Belfiori G, Arcidiacono PG, Capurso G, Apadula L, Zaccari P, Noia JL, Gorris M, Busch O, Ponweera A, Mann K, Demir IE, Phillip V, Ahmad N, Hackert T, Heckler M, Lennon AM, Afghani E, Vallicella D, Dall'Olio T, Nepi A, Vollmer CM, Friess H, Ghaneh P, Besselink M, Falconi M, Bassi C, Goh BK, Jang JY, Fernández-Del Castillo C, Salvia R
Gastroenterology 2023 Oct;165(4):1016-1024.e5. Epub 2023 Jul 4 doi: 10.1053/j.gastro.2023.06.022. PMID: 37406887Free PMC Article
Pancreatic Cysts: Radiology.
Megibow AJ
Gastrointest Endosc Clin N Am 2023 Jul;33(3):519-531. Epub 2023 Apr 24 doi: 10.1016/j.giec.2023.03.008. PMID: 37245933
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Diagnosis

Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation.
Marchegiani G, Pollini T, Burelli A, Han Y, Jung HS, Kwon W, Rocha Castellanos DM, Crippa S, Belfiori G, Arcidiacono PG, Capurso G, Apadula L, Zaccari P, Noia JL, Gorris M, Busch O, Ponweera A, Mann K, Demir IE, Phillip V, Ahmad N, Hackert T, Heckler M, Lennon AM, Afghani E, Vallicella D, Dall'Olio T, Nepi A, Vollmer CM, Friess H, Ghaneh P, Besselink M, Falconi M, Bassi C, Goh BK, Jang JY, Fernández-Del Castillo C, Salvia R
Gastroenterology 2023 Oct;165(4):1016-1024.e5. Epub 2023 Jul 4 doi: 10.1053/j.gastro.2023.06.022. PMID: 37406887Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Intraductal Papillary Mucinous Neoplasm of the Pancreas.
Fong ZV, Fernández-Del Castillo C
Surg Clin North Am 2016 Dec;96(6):1431-1445. doi: 10.1016/j.suc.2016.07.009. PMID: 27865286

Therapy

Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms.
de la Fuente J, Chatterjee A, Lui J, Nehra AK, Bell MG, Lennon RJ, Kassmeyer BA, Graham RP, Nagayama H, Schulte PJ, Doering KA, Delgado AM, Vege SS, Chari ST, Takahashi N, Majumder S
JAMA Netw Open 2023 Oct 2;6(10):e2337799. doi: 10.1001/jamanetworkopen.2023.37799. PMID: 37847503Free PMC Article
Management and outcomes of intraductal papillary mucinous neoplasms.
Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA
BJS Open 2019 Aug;3(4):490-499. Epub 2019 Mar 21 doi: 10.1002/bjs5.50156. PMID: 31388641Free PMC Article
Enucleation for branch duct intraductal papillary mucinous neoplasms: a systematic review and meta-analysis.
Ratnayake CB, Biela C, Windsor JA, Pandanaboyana S
HPB (Oxford) 2019 Dec;21(12):1593-1602. Epub 2019 May 29 doi: 10.1016/j.hpb.2019.04.015. PMID: 31153837
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.
Ooka K, Rustagi T, Evans A, Farrell JJ
Pancreas 2017 Aug;46(7):927-935. doi: 10.1097/MPA.0000000000000858. PMID: 28697134
Secretin-enhanced MR cholangiopancreatography: spectrum of findings.
Tirkes T, Sandrasegaran K, Sanyal R, Sherman S, Schmidt CM, Cote GA, Akisik F
Radiographics 2013 Nov-Dec;33(7):1889-906. doi: 10.1148/rg.337125014. PMID: 24224585

Prognosis

Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge?
Fritz S, Hackert T, Büchler MW
Dig Dis 2015;33(1):99-105. Epub 2014 Dec 17 doi: 10.1159/000368448. PMID: 25531503
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Clinical prediction guides

Management Algorithms for Pancreatic Cystic Neoplasms.
Kim HS, Jang JY
Arch Pathol Lab Med 2022 Mar 1;146(3):322-329. doi: 10.5858/arpa.2020-0395-RA. PMID: 33503225
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
The management of intraductal papillary mucinous neoplasms of the pancreas.
Pollini T, Andrianello S, Caravati A, Perri G, Malleo G, Paiella S, Marchegiani G, Salvia R
Minerva Chir 2019 Oct;74(5):414-421. doi: 10.23736/S0026-4733.19.08145-8. PMID: 31795628
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent systematic reviews

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.
Paolino G, Esposito I, Hong SM, Basturk O, Mattiolo P, Kaneko T, Veronese N, Scarpa A, Adsay V, Luchini C
Histopathology 2022 Sep;81(3):297-309. Epub 2022 May 27 doi: 10.1111/his.14698. PMID: 35583805Free PMC Article
Association between pancreatic intraductal papillary mucinous neoplasms and extrapancreatic malignancies: A systematic review with meta-analysis.
Facciorusso A, Crinò SF, Ramai D, Marchegiani G, Lester J, Singh J, Lisotti A, Fusaroli P, Cannizzaro R, Gkolfakis P, Papanikolaou IS, Triantafyllou K, Singh S
Eur J Surg Oncol 2022 Mar;48(3):632-639. Epub 2021 Oct 1 doi: 10.1016/j.ejso.2021.09.018. PMID: 34620511
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Branch Duct Intraductal Papillary Mucinous Neoplasms: Recommendations for Follow-Up and Surgery.
Caravati A, Andrianello S, Pollini T, Biancotto M, Balduzzi A, Malleo G, Salvia R, Marchegiani G
Scand J Surg 2020 Mar;109(1):34-41. Epub 2020 Feb 2 doi: 10.1177/1457496919900414. PMID: 32009571
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.
Ooka K, Rustagi T, Evans A, Farrell JJ
Pancreas 2017 Aug;46(7):927-935. doi: 10.1097/MPA.0000000000000858. PMID: 28697134

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