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Non-Rh Blood Group Isoimmunization

MedGen UID:
821551
•Concept ID:
C3828803
•
Finding
Synonym: Blood Group Isoimmunization

Definition

The mother develops antibodies against red blood cell non-Rhesus antigens. This may lead to potential fetal adverse outcomes such as anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Rh Blood Group Isoimmunization

Recent clinical studies

Etiology

Neonatal and Obstetrical Outcomes of Pregnancies Complicated by Alloimmunization.
Bahr TM, Tweddell SM, Zalla JM, Dizon-Townson D, Ohls RK, Henry E, Ilstrup SJ, Kelley WE, Ling CY, Lindgren PC, O'Brien EA, Christensen RD
Pediatrics 2024 Jun 1;153(6) doi: 10.1542/peds.2023-064604. PMID: 38784990
Relationship between maternal antibody type and antenatal course following intrauterine transfusion for red cell alloimmunisation.
Walsh CA, Russell N, McAuliffe FM, Higgins S, Mahony R, Carroll S, McParland P
Eur J Obstet Gynecol Reprod Biol 2013 Dec;171(2):235-9. Epub 2013 Sep 8 doi: 10.1016/j.ejogrb.2013.09.002. PMID: 24075591
The clinical outcome of non-RhD antibody affected pregnancies in Northern Ireland.
Chandrasekar A, Morris KG, Tubman TR, Tharma S, McClelland WM
Ulster Med J 2001 Nov;70(2):89-94. PMID: 11795772Free PMC Article
Management of pregnancies complicated by rhesus (D) antibodies.
Welch CR, Makepeace PA, Walkinshaw SA
Br J Hosp Med 1993 Jun 2-15;49(11):813-6. PMID: 8334486
Percutaneous umbilical blood sampling: results from a multicenter collaborative registry. The Western Collaborative Perinatal Group.
Hickok DE, Mills M
Am J Obstet Gynecol 1992 Jun;166(6 Pt 1):1614-7; discussion 1617-8. doi: 10.1016/0002-9378(92)91550-t. PMID: 1615968

Diagnosis

Neonatal and Obstetrical Outcomes of Pregnancies Complicated by Alloimmunization.
Bahr TM, Tweddell SM, Zalla JM, Dizon-Townson D, Ohls RK, Henry E, Ilstrup SJ, Kelley WE, Ling CY, Lindgren PC, O'Brien EA, Christensen RD
Pediatrics 2024 Jun 1;153(6) doi: 10.1542/peds.2023-064604. PMID: 38784990
Percutaneous umbilical blood sampling: results from a multicenter collaborative registry. The Western Collaborative Perinatal Group.
Hickok DE, Mills M
Am J Obstet Gynecol 1992 Jun;166(6 Pt 1):1614-7; discussion 1617-8. doi: 10.1016/0002-9378(92)91550-t. PMID: 1615968

Therapy

Percutaneous umbilical blood sampling: results from a multicenter collaborative registry. The Western Collaborative Perinatal Group.
Hickok DE, Mills M
Am J Obstet Gynecol 1992 Jun;166(6 Pt 1):1614-7; discussion 1617-8. doi: 10.1016/0002-9378(92)91550-t. PMID: 1615968

Prognosis

Neonatal and Obstetrical Outcomes of Pregnancies Complicated by Alloimmunization.
Bahr TM, Tweddell SM, Zalla JM, Dizon-Townson D, Ohls RK, Henry E, Ilstrup SJ, Kelley WE, Ling CY, Lindgren PC, O'Brien EA, Christensen RD
Pediatrics 2024 Jun 1;153(6) doi: 10.1542/peds.2023-064604. PMID: 38784990
Relationship between maternal antibody type and antenatal course following intrauterine transfusion for red cell alloimmunisation.
Walsh CA, Russell N, McAuliffe FM, Higgins S, Mahony R, Carroll S, McParland P
Eur J Obstet Gynecol Reprod Biol 2013 Dec;171(2):235-9. Epub 2013 Sep 8 doi: 10.1016/j.ejogrb.2013.09.002. PMID: 24075591

Clinical prediction guides

Neonatal and Obstetrical Outcomes of Pregnancies Complicated by Alloimmunization.
Bahr TM, Tweddell SM, Zalla JM, Dizon-Townson D, Ohls RK, Henry E, Ilstrup SJ, Kelley WE, Ling CY, Lindgren PC, O'Brien EA, Christensen RD
Pediatrics 2024 Jun 1;153(6) doi: 10.1542/peds.2023-064604. PMID: 38784990

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