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Atypical Cartilaginous Tumor

MedGen UID:
824671
•Concept ID:
C3838825
•
Neoplastic Process
Synonyms: Atypical cartilaginous tumor; Chondrosarcoma, grade 1
SNOMED CT: Chondrosarcoma, grade 1 (703701000); Atypical cartilaginous tumor (703701000)

Definition

A locally aggressive, low grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma in the appendicular skeleton. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Cartilaginous Tumor

Professional guidelines

PubMed

Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678

Recent clinical studies

Etiology

Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.
Abdelhafeez AH, Mothi SS, Pio L, Mori M, Santiago TC, McCarville MB, Kaste SC, Pappo AS, Talbot LJ, Murphy AJ, Davidoff AM
Pediatr Blood Cancer 2023 Oct;70(10):e30437. Epub 2023 May 17 doi: 10.1002/pbc.30437. PMID: 37194488Free PMC Article
Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
MRI radiomics-based machine-learning classification of bone chondrosarcoma.
Gitto S, Cuocolo R, Albano D, Chianca V, Messina C, Gambino A, Ugga L, Cortese MC, Lazzara A, Ricci D, Spairani R, Zanchetta E, Luzzati A, Brunetti A, Parafioriti A, Sconfienza LM
Eur J Radiol 2020 Jul;128:109043. Epub 2020 May 7 doi: 10.1016/j.ejrad.2020.109043. PMID: 32438261
Enchondromas and atypical cartilaginous tumors at the proximal humerus treated with intralesional resection and bone cement filling with or without osteosynthesis: retrospective analysis of 42 cases with 6 years mean follow-up.
Omlor GW, Lohnherr V, Lange J, Gantz S, Merle C, Fellenberg J, Raiss P, Lehner B
World J Surg Oncol 2018 Jul 13;16(1):139. doi: 10.1186/s12957-018-1437-z. PMID: 30005680Free PMC Article
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678

Diagnosis

Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.
Abdelhafeez AH, Mothi SS, Pio L, Mori M, Santiago TC, McCarville MB, Kaste SC, Pappo AS, Talbot LJ, Murphy AJ, Davidoff AM
Pediatr Blood Cancer 2023 Oct;70(10):e30437. Epub 2023 May 17 doi: 10.1002/pbc.30437. PMID: 37194488Free PMC Article
Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Assessment of central cartilaginous tumor of the appendicular bone: inter-observer and intermodality agreement and comparison of diagnostic performance of CT and MRI.
Lee S, Yoon MA
Acta Radiol 2022 Mar;63(3):376-386. Epub 2021 Feb 27 doi: 10.1177/0284185121996268. PMID: 33641451
Malignant Cartilage-Forming Tumors.
Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083

Therapy

Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.
Abdelhafeez AH, Mothi SS, Pio L, Mori M, Santiago TC, McCarville MB, Kaste SC, Pappo AS, Talbot LJ, Murphy AJ, Davidoff AM
Pediatr Blood Cancer 2023 Oct;70(10):e30437. Epub 2023 May 17 doi: 10.1002/pbc.30437. PMID: 37194488Free PMC Article
Can low-grade chondrosarcoma in flat bones be treated with intralesional curettage and cryotherapy?
Park K, Krumme J, Adebayo M, Adams BW, Henshaw RM
J Surg Oncol 2023 Mar;127(3):473-479. Epub 2022 Oct 17 doi: 10.1002/jso.27123. PMID: 36250903
MRI radiomics-based machine-learning classification of bone chondrosarcoma.
Gitto S, Cuocolo R, Albano D, Chianca V, Messina C, Gambino A, Ugga L, Cortese MC, Lazzara A, Ricci D, Spairani R, Zanchetta E, Luzzati A, Brunetti A, Parafioriti A, Sconfienza LM
Eur J Radiol 2020 Jul;128:109043. Epub 2020 May 7 doi: 10.1016/j.ejrad.2020.109043. PMID: 32438261
Survival and prognostic factors in conventional G1 chondrosarcoma.
Fromm J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Birkenmaier C, Roeder F, Jansson V, Dürr HR
World J Surg Oncol 2019 Sep 3;17(1):155. doi: 10.1186/s12957-019-1695-4. PMID: 31481076Free PMC Article
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678

Prognosis

Malignant Cartilage-Forming Tumors.
Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Chondrosarcoma local recurrence in the Cancer Registry of Norway cohort (1990-2013): Patterns and impact.
Thorkildsen J, Norum OJ, Myklebust TA, Zaikova O
J Surg Oncol 2021 Feb;123(2):510-520. Epub 2020 Dec 14 doi: 10.1002/jso.26308. PMID: 33314135
Survival and prognostic factors in conventional G1 chondrosarcoma.
Fromm J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Birkenmaier C, Roeder F, Jansson V, Dürr HR
World J Surg Oncol 2019 Sep 3;17(1):155. doi: 10.1186/s12957-019-1695-4. PMID: 31481076Free PMC Article
Enchondromas and atypical cartilaginous tumors at the proximal humerus treated with intralesional resection and bone cement filling with or without osteosynthesis: retrospective analysis of 42 cases with 6 years mean follow-up.
Omlor GW, Lohnherr V, Lange J, Gantz S, Merle C, Fellenberg J, Raiss P, Lehner B
World J Surg Oncol 2018 Jul 13;16(1):139. doi: 10.1186/s12957-018-1437-z. PMID: 30005680Free PMC Article
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678

Clinical prediction guides

Nasal chondrogenic tumors: Case reports of primary chondroma and recurrence of atypical cartilaginous tumor (chondrosarcoma grade I) with review of the literature.
Giotakis AI, Yiotakis I, Mellou A, Koufopoulos N, Giotakis EI
Indian J Cancer 2023 Apr-Jun;60(2):248-252. doi: 10.4103/ijc.IJC_1341_20. PMID: 37530248
Assessment of central cartilaginous tumor of the appendicular bone: inter-observer and intermodality agreement and comparison of diagnostic performance of CT and MRI.
Lee S, Yoon MA
Acta Radiol 2022 Mar;63(3):376-386. Epub 2021 Feb 27 doi: 10.1177/0284185121996268. PMID: 33641451
Malignant Cartilage-Forming Tumors.
Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Enchondromas and atypical cartilaginous tumors at the proximal humerus treated with intralesional resection and bone cement filling with or without osteosynthesis: retrospective analysis of 42 cases with 6 years mean follow-up.
Omlor GW, Lohnherr V, Lange J, Gantz S, Merle C, Fellenberg J, Raiss P, Lehner B
World J Surg Oncol 2018 Jul 13;16(1):139. doi: 10.1186/s12957-018-1437-z. PMID: 30005680Free PMC Article

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