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Squamous Intraepithelial Lesions of the Cervix

MedGen UID:
827260
•Concept ID:
C3850166
•
Finding

Definition

A cytological test finding often from PAP SMEARS that shows abnormal lesions of SQUAMOUS EPITHELIAL CELLS of the CERVIX. It is a diagnostic criterion used in the Bethesda System for UTERINE CERVICAL NEOPLASMS and represents the PAP TEST result that is abnormal. Although squamous intraepithelial lesions test result does not mean UTERINE CERVICAL NEOPLASMS it requires follow-ups (e.g., HPV DNA TESTS; and COLPOSCOPY). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Intraepithelial Lesions of the Cervix

Professional guidelines

PubMed

Revised terminology for cervical histopathology and its implications for management of high-grade squamous intraepithelial lesions of the cervix.
Waxman AG, Chelmow D, Darragh TM, Lawson H, Moscicki AB
Obstet Gynecol 2012 Dec;120(6):1465-71. doi: 10.1097/aog.0b013e31827001d5. PMID: 23168774Free PMC Article
Human papillomavirus type 16-specific T cell responses and their association with recurrence of cervical disease following treatment.
Luxton JC, Nath R, Derias N, Herbert A, Shepherd PS
J Gen Virol 2003 May;84(Pt 5):1063-1070. doi: 10.1099/vir.0.18931-0. PMID: 12692269
See-and-treat in the management of high-grade squamous intraepithelial lesions of the cervix: a resource utilization analysis.
Holschneider CH, Ghosh K, Montz FJ
Obstet Gynecol 1999 Sep;94(3):377-85. doi: 10.1016/s0029-7844(99)00337-3. PMID: 10472863

Recent clinical studies

Etiology

Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
Association Between Vulvar Squamous Intraepithelial Lesions and Psychiatric Illness.
Bell SG, Kobernik EK, Haefner HK, Welch KC
J Low Genit Tract Dis 2021 Jan 1;25(1):53-56. doi: 10.1097/LGT.0000000000000580. PMID: 33181537
Factors predicting the spontaneous regression of cervical high-grade squamous intraepithelial lesions (HSIL/CIN2).
Brun JL, Letoffet D, Marty M, Griffier R, Ah-Kit X, Garrigue I
Arch Gynecol Obstet 2021 Apr;303(4):1065-1073. Epub 2020 Nov 11 doi: 10.1007/s00404-020-05853-3. PMID: 33175197
The Role of Cytology in the 21st Century: The Integration of Cells and Molecules.
Bergeron C, von Knebel Doeberitz M
Acta Cytol 2016;60(6):540-542. Epub 2016 Oct 28 doi: 10.1159/000449402. PMID: 27788516
The terminology of pre-invasive cervical lesions in the UK cervical screening programme.
Herrington CS
Cytopathology 2015 Dec;26(6):346-50. doi: 10.1111/cyt.12307. PMID: 26767601

Diagnosis

Cervical Cancer Screening: A Review.
Perkins RB, Wentzensen N, Guido RS, Schiffman M
JAMA 2023 Aug 8;330(6):547-558. doi: 10.1001/jama.2023.13174. PMID: 37552298
Cytology and curetting diagnosis of endocervical adenocarcinoma.
Bruehl FK, Dyhdalo KS, Hou Y, Clapacs E, Przybycin CG, Reynolds JP
J Am Soc Cytopathol 2020 Nov-Dec;9(6):556-562. Epub 2020 Jun 5 doi: 10.1016/j.jasc.2020.05.007. PMID: 32624383
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Human Papillomavirus Infection of the Skin.
Bacaj P, Burch D
Arch Pathol Lab Med 2018 Jun;142(6):700-705. doi: 10.5858/arpa.2017-0572-RA. PMID: 29848038
The LAST Project and the diagnostic bottom line.
Darragh TM
Cytopathology 2015 Dec;26(6):343-5. doi: 10.1111/cyt.12299. PMID: 26767600

Therapy

The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer.
Avila E, Noriega-Mejía BJ, González-Macías J, Cortes-Hernández U, García-Quiroz J, García-Becerra R, Díaz L
Int J Mol Sci 2023 May 12;24(10) doi: 10.3390/ijms24108665. PMID: 37240017Free PMC Article
Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions.
Hu Y, Li Y, Xu Y, Teng Y, Chen J, Ma L
Photodiagnosis Photodyn Ther 2022 Sep;39:103037. Epub 2022 Jul 26 doi: 10.1016/j.pdpdt.2022.103037. PMID: 35905829
Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials.
Tang J, Li M, Zhao C, Shen D, Liu L, Zhang X, Wei L
Viruses 2022 Jan 25;14(2) doi: 10.3390/v14020239. PMID: 35215833Free PMC Article
Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
The Role of Cytology in the 21st Century: The Integration of Cells and Molecules.
Bergeron C, von Knebel Doeberitz M
Acta Cytol 2016;60(6):540-542. Epub 2016 Oct 28 doi: 10.1159/000449402. PMID: 27788516

Prognosis

Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials.
Tang J, Li M, Zhao C, Shen D, Liu L, Zhang X, Wei L
Viruses 2022 Jan 25;14(2) doi: 10.3390/v14020239. PMID: 35215833Free PMC Article
Factors predicting the spontaneous regression of cervical high-grade squamous intraepithelial lesions (HSIL/CIN2).
Brun JL, Letoffet D, Marty M, Griffier R, Ah-Kit X, Garrigue I
Arch Gynecol Obstet 2021 Apr;303(4):1065-1073. Epub 2020 Nov 11 doi: 10.1007/s00404-020-05853-3. PMID: 33175197
From squamous intraepithelial lesions to cervical cancer: Circulating microRNAs as potential biomarkers in cervical carcinogenesis.
Berti FCB, Salviano-Silva A, Beckert HC, de Oliveira KB, Cipolla GA, Malheiros D
Biochim Biophys Acta Rev Cancer 2019 Dec;1872(2):188306. Epub 2019 Aug 6 doi: 10.1016/j.bbcan.2019.08.001. PMID: 31398380
Value of top-hat procedure in management of squamous intraepithelial lesion.
Leng F, Jiang L, Nong L, Ren X, Xie T, Dong Y, Tao X
J Obstet Gynaecol Res 2019 Jan;45(1):182-188. Epub 2018 Sep 6 doi: 10.1111/jog.13781. PMID: 30191638
Natural History of Squamous Intraepithelial Lesions in Pregnancy and Mode of Delivery.
Schuster S, Joura E, Kohlberger P
Anticancer Res 2018 Apr;38(4):2439-2442. doi: 10.21873/anticanres.12496. PMID: 29599374

Clinical prediction guides

Cervical Cancer Screening: A Review.
Perkins RB, Wentzensen N, Guido RS, Schiffman M
JAMA 2023 Aug 8;330(6):547-558. doi: 10.1001/jama.2023.13174. PMID: 37552298
The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer.
Avila E, Noriega-Mejía BJ, González-Macías J, Cortes-Hernández U, García-Quiroz J, García-Becerra R, Díaz L
Int J Mol Sci 2023 May 12;24(10) doi: 10.3390/ijms24108665. PMID: 37240017Free PMC Article
Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
Factors predicting the spontaneous regression of cervical high-grade squamous intraepithelial lesions (HSIL/CIN2).
Brun JL, Letoffet D, Marty M, Griffier R, Ah-Kit X, Garrigue I
Arch Gynecol Obstet 2021 Apr;303(4):1065-1073. Epub 2020 Nov 11 doi: 10.1007/s00404-020-05853-3. PMID: 33175197
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775

Recent systematic reviews

Association of Polymorphisms in Cytokine genes with susceptibility to Precancerous Lesions and Cervical Cancer: A systematic review with meta-analysis.
de Moura EL, Dos Santos ACM, da Silva DM, Dos Santos BB, Figueredo DS, Moura AWA, da Silva AF, Tanabe ISB, de Lira Tanabe EL, Lira Neto AB, Pereira E Silva AC, de Carvalho Fraga CA, de Lima Filho JL, de Farias KF, Martins de Souza EV
Immunol Invest 2021 Jul;50(5):492-526. Epub 2020 Jun 30 doi: 10.1080/08820139.2020.1778023. PMID: 32602796
Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Immunohistochemical expression of p16, Ki-67 and p53 in cervical lesions - A systematic review.
Silva DC, Gonçalves AK, Cobucci RN, Mendonça RC, Lima PH, Cavalcanti G Júnior
Pathol Res Pract 2017 Jul;213(7):723-729. Epub 2017 Mar 14 doi: 10.1016/j.prp.2017.03.003. PMID: 28554769
A systematic review of p16/Ki-67 immuno-testing for triage of low grade cervical cytology.
Kisser A, Zechmeister-Koss I
BJOG 2015 Jan;122(1):64-70. Epub 2014 Sep 11 doi: 10.1111/1471-0528.13076. PMID: 25208923

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